Share This Author
Ginseng Therapy in Non-Insulin-Dependent Diabetic Patients: Effects on psychophysical performance, glucose homeostasis, serum lipids, serum aminoterminalpropeptide concentration, and body weight
Ginseng therapy elevated mood, improved psychophysical performance, and reduced fasting blood glucose (FBG) and body weight, and Ginseng may be a useful therapeutic adjunct in the management of NIDDM.
Age and cytochrome P450‐linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions
Liver Function Tests in Diabetic Patients
In multivariate analysis, outpatients who were overweight, showed poor diabetes control during a short duration of diabetes controlled by treatment with diet or oral agents, and had a mature age at onset of diabetes displayed the most significant clinical explanatory variables associated with abnormal Alt.
The effect of cigarette smoking on 7-ethoxyresorufin O-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies.
Cigarette smoking induces a form of P-450 in human liver, responsible for ERDE activity, that contains an epitope recognized by MAb 1-7-1 and is insensitive to MAb 2-66-3 and is not contributing to AHH, CH or ECDE activities of human liver.
Diabetes and elimination of antipyrine in man: an analysis of 298 patients classified by type of diabetes, age, sex, duration of disease and liver involvement.
- E. Sotaniemi, O. Pelkonen, A. Arranto, P. Tapanainen, A. Rautio, M. Pasanen
- MedicinePharmacology & toxicology
- 1 March 2002
Drug metabolism in diabetes is affected by the type of disease, therapy and its effectiveness, and age and gender of the patients, and these factors should be taken into account when evaluating overall drug metabolism in diabetic patients.
CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients.
- E. Sotaniemi, A. Rautio, M. Bäckstrom, P. Arvela, O. Pelkonen
- Medicine, BiologyBritish journal of clinical pharmacology
The usefulness of monitoring serum MEGX concentrations and urinary 7OHC excretion to reflect liver function in patients with liver, kidney and epileptic disease and in control subjects is investigated.
Enzyme Inducers Improve Insulin Sensitivity in Non-insulin-dependent Diabetic Subjects
The antipyrine clearance rate correlated with insulin-mediated glucose metabolism (r2 = 0.560) could be interpreted as indicating that, in NIDDM patients, peripheral glucose utilization and the liver microsomal enzyme system share common regulators.
Pharmacokinetics of ftorafur after intravenous and oral administration
- M. Anttila, E. Sotaniemi, M. Kairaluoma, R. Mokka, Hannu T. Sundquist
- Medicine, BiologyCancer Chemotherapy and Pharmacology
The pharmacokinetics of ftorafur, an antineoplastic agent, has been studied in seven cancer patients by determining concentrations of the unchanged compound in serum after single IV and PO doses of 2 g FT by a new quantitative thin-layer chromatographic method.
Heterogeneity of the antigens related to the aminoterminal propeptide of type III procollagen in human serum.
Coumarin 7-hydroxylase activity in human liver microsomes. Properties of the enzyme and interspecies comparisons.
The correlations between coumarin 7-hydroxylation and antipyrine half-life or clearance are statistically significant, but not good enough for predictive purposes.