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cytochrome P450 3A

Known as: Erythromycin N Demethylase, Cytochrome P 450IIIA, Cytochrome P-450 CYP3A 
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Prasugrel and clopidogrel inhibit platelet aggregation through active metabolite formation. Prasugrel's active metabolite (R… Expand
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Highly Cited
2006
Highly Cited
2006
Cytochromes P450 (P450s) 3A, 2C, and 1A2 constitute the major “pieces” of the human liver P450 “pie” and account, on average, for… Expand
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Review
2005
Review
2005
Consistent with its highest abundance in humans, cytochrome P450 (CYP) 3A is responsible for the metabolism of about 60% of… Expand
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Review
2003
Review
2003
The use of many halogenated alkanes such as carbon tetrachloride (CCl4), chloroform (CHCl3) or iodoform (CHI3), has been banned… Expand
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Highly Cited
2002
Highly Cited
2002
The elucidation of the individual contributions of the four CYP3A genes to the overall CYP3A activity has been hampered by… Expand
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Review
2002
Review
2002
Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large differences in the pharmacokinetics of a number of… Expand
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Highly Cited
2001
Highly Cited
2001
Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid levels and responses to half of all… Expand
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Review
1999
Review
1999
The maturation of organ systems during fetal life and childhood exerts a profound effect on drug disposition. The maturation of… Expand
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Highly Cited
1999
Highly Cited
1999
The cytochrome P450 3A (CYP3A) isoforms are responsible for the metabolism of a majority of therapeutic compounds, and they are… Expand
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Review
1998
Review
1998
Cytochrome P450 3A4 (CYP3A4), the major phase I drug metabolizing enzyme in humans, and the MDR1 gene product P-glycoprotein (P… Expand
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