cytochrome P450 3A

Known as: Erythromycin N Demethylase, Cytochrome P 450IIIA, Cytochrome P-450 CYP3A 
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Prasugrel and clopidogrel inhibit platelet aggregation through active metabolite formation. Prasugrel's active metabolite (R… (More)
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Highly Cited
2006
Highly Cited
2006
Cytochromes P450 (P450s) 3A, 2C, and 1A2 constitute the major "pieces" of the human liver P450 "pie" and account, on average, for… (More)
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Review
2004
Review
2004
CYP3A isozymes collectively comprise the largest portion of the liver and small intestinal CYP protein and they are involved in… (More)
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Highly Cited
2002
Highly Cited
2002
The elucidation of the individual contributions of the four CYP3A genes to the overall CYP3A activity has been hampered by… (More)
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Review
2002
Review
2002
Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large differences in the pharmacokinetics of a number of… (More)
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Review
2001
Review
2001
Intestinal phase I metabolism and active extrusion of absorbed drug have recently been recognised as major determinants of oral… (More)
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Review
1999
Review
1999
The maturation of organ systems during fetal life and childhood exerts a profound effect on drug disposition. The maturation of… (More)
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Review
1998
Review
1998
Cytochrome P450 3A4 (CYP3A4), the major phase I drug metabolizing enzyme in humans, and the MDR1 gene product P-glycoprotein (P… (More)
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Highly Cited
1996
Highly Cited
1996
It has been proposed that excessive intrarenal conversion of cortisol to 6 beta-hydroxycortisol by CYP3A may mediate increased… (More)
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Highly Cited
1994
Highly Cited
1994
The capabilities of cytochrome P4503A4 (CYP3A4), CYP3A5, and fetal hepatic microsomes containing CYP3A7 to metabolize midazolam… (More)
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