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Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase.
The demonstration of in vivo arachidonic acid epoxidation and omega-hydroxylation established the cytochrome P450 epoxygenase and omega/omega-1 hydroxylase as formal metabolic pathways and as membersExpand
Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension
The association of the T8590C variant with hypertension supports its role as a polygenic determinant of blood pressure control in humans, and results obtained from the large population database suggest that the relevance of the variant may vary according to hypertension comorbidity. Expand
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension
It is concluded that the androgen-mediated regulation of Cyp 4a arachidonate monooxygenases is an important component of the renal mechanisms that control systemic blood pressures. Expand
The CYP4A Isoforms Hydroxylate Epoxyeicosatrienoic Acids to Form High Affinity Peroxisome Proliferator-activated Receptor Ligands*
Comparisons of reaction rates and catalytic efficiency showed that EETs are one of the best endogenous substrates so far described for rat CYP4A isoforms, suggesting a role for them as endogenous ligands for these orphan nuclear receptors. Expand
Soluble Epoxide Hydrolase Inhibition Lowers Arterial Blood Pressure in Angiotensin II Hypertension
It is demonstrated that increased sEH expression in the Ang II hypertensive kidney leads to increased EET hydration, and inhibition of sEH during Ang II hypertension is antihypertensive. Expand
Human cytochromes P450
This review deals with aspects of cytochrome P450s of relevance to human physiology, biochemistry, pharmacology and medicine, including their role in metabolism of endogenous compounds such as steroids and eicosanoids, and the effect of disease on CYP function, CYPs and cancer. Expand
The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading.
Inhibition and immunoelectrophoresis experiments demonstrated that P-450 2C23 is the major 2C arachidonic acid epoxygenase in the rat kidney and the renal P- 450 isoform regulated by excess dietary salt intake. Expand
An Active Site Substitution, F87V, Converts Cytochrome P450 BM-3 into a Regio- and Stereoselective (14S,15R)-Arachidonic Acid Epoxygenase*
It is proposed that fatty acid oxidation by P450 BM-3 is incompatible with the presence of residues with negatively charged side chains at the surface opening of the substrate access channel or a polar aromatic side chain in the vicinity of the heme iron. Expand
Cytochrome P450 and the arachidonate cascade 1
Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450‐mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well asExpand
The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance.
It is concluded that CYP2B4, an abundant rabbit lung cytochrome P450 enzyme, is the primary constitutive pulmonary arachidonic acid epoxygenase and that these locally produced, biologically active eicosanoids may be involved in maintaining homeostasis within the lung. Expand