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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
TLDR
The results presented in this study provide useful information for the study of drug biotransformation in humans and for the basis of drug toxicities, carcinogenesis and teratogenesis. Expand
Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.
  • F. Guengerich
  • Chemistry, Medicine
  • Chemical research in toxicology
  • 5 May 2001
TLDR
P450s also catalyze less generally discussed reactions including reduction, desaturation, ester cleavage, ring expansion, ring formation, aldehyde scission, dehydration, ipso attack, coupling reactions, rearrangement of fatty acid and prostaglandin hydroperoxides, and phospholipase activity. Expand
Cytochrome p450 and chemical toxicology.
  • F. Guengerich
  • Chemistry, Medicine
  • Chemical research in toxicology
  • 2008
TLDR
Crystal structures of several of the major human P450s are now in hand, and unresolved problems include the characterization of the minor "orphan" P 450s, ligand cooperativity and kinetic complexity of several P450S, the prediction of metabolism, the overall contribution of bioactivation to drug idiosyncratic problems, the extrapolation of animal test results to humans in drug development, and the contribution of genetic variation in human P550s to cancer incidence. Expand
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.
TLDR
The selectivity of this enzyme in the activation of a variety of environmental carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002 or NM2009 tester strains was examined using the SOS response as an end point of DNA damage. Expand
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.
TLDR
The likelihood that this ancient gene superfamily has existed for more than 3.5 billion years, and that the rate of P450 gene evolution appears to be quite nonlinear, is discussed. Expand
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects.
TLDR
The results collectively indicate that P-450 IIE1 is a major catalyst of the oxidation of benzene, styrene, CCl4, CHCl3, CH2Cl2, CH3Cl, 1,2-dichloropropane, ethylene dichloride, vinyl chloride, vinyl bromide, acrylonitrile, vinyl carbamate, ethylcarbamate, and trichloroethylene. Expand
Cytochrome P-450 3A4: regulation and role in drug metabolism.
  • F. Guengerich
  • Biology, Medicine
  • Annual review of pharmacology and toxicology
  • 1999
TLDR
Several issues remain to be resolved regarding the catalytic activity of the P-450 3A4 protein, including rate-limiting steps and the need for cytochrome b5, divalent cations, and acidic phospholipid systems for optimal activity. Expand
Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).
TLDR
It was observed that P450IIIA5 was detected in a statistically significantly higher percentage of children and adolescents (19 years old and under), as compared with the remaining population (8 of 17, 47%, versus 11 of 46, 24%, respectively). Expand
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1.
TLDR
Results provide strong evidence that P-450IIE1 is the primary catalyst of chlorzoxazone 6-hydroxylation in human liver and may have potential use as a noninvasive probe in estimating the in vivo expression of the protein. Expand
Cytochrome P450s and other enzymes in drug metabolism and toxicity
TLDR
What fraction of drug toxicity actually involves metabolism, and how species and human interindividual variations affect pharmacokinetics and toxicity are considered are considered. Expand
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