In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus

@article{Henderson2000InVI,
  title={In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus},
  author={Marilyn C. Henderson and Cristobal L. Miranda and J. Frederik Stevens and Max L. Deinzer and Donald Raymond Buhler},
  journal={Xenobiotica},
  year={2000},
  volume={30},
  pages={235 - 251}
}
1. Several unique flavonoid compounds have recently been isolated from hops, Humulus lupulus, and their presence has been detected in beer. Their chemical structures are similar to other plant-derived compounds, many present in the human diet, that have been shown to have cancer chemopreventive properties due, in part, to inhibition of cytochrome P450 enzymes that activate carcinogens. Additionally, preliminary studies have shown these flavonoids (at 100 muM) to be inhibitory of P450-mediated… 
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