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CYP3A4 wt Allele

Known as: CYPIIIA4, P450-PCN1, CYP3A 
Human CYP3A4 wild-type allele is located in the vicinity of 7q21.1 and is approximately 27 kb in length. This allele, which encodes cytochrome P450… 
National Institutes of Health

Related topics

Related topics

17 relations
7q22.1CYP3A4 geneCarcinogen MetabolismHomo sapiens

Broader (1)

Cyp3a13 protein, mouse

Papers overview

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Highly Cited
2009
Highly Cited
2009
Direct cancer–stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells
Background:Scirrhous-type gastric carcinoma (SGC) exhibits an extensive submucosal fibrosis and extremely poor patient prognosis… 
Highly Cited
1997
Highly Cited
1997
Toluene metabolism by cDNA-expressed human hepatic cytochrome P450.
Highly Cited
1994
Highly Cited
1994
CYP3A gene expression in human gut epithelium.
CYP3A4, a major Phase I xenobiotic metabolizing enzyme present in liver, is also present in human small bowel epithelium where it… 
Highly Cited
1994
Highly Cited
1994
Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450.
The rate of formation of styrene glycol from styrene was compared in human, rat, and mouse liver microsomes. At a low styrene… 
Highly Cited
1993
Highly Cited
1993
Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta.
Placenta and endometrium carry out steroidogenic biotransformation reactions such as 6-beta-hydroxylation of cortisol, a reaction… 
Highly Cited
1992
Highly Cited
1992
Nearly ubiquitous tissue distribution of the scrapie agent precursor protein
The “modified host protein” model of scrapie proposes that the transmissible agent is composed of the degradation-resistant… 
Highly Cited
1991
Highly Cited
1991
Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism.
4-Ipomeanol is a pulmonary toxin in cattle and rodents that is metabolically activated by cytochromes P-450 (P-450s). P-450… 
Highly Cited
1988
Highly Cited
1988
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
P450PCN protein levels and nifedipine oxidase activities were quantitated in 12 human livers and were shown to be highly… 
Highly Cited
1988
Highly Cited
1988
Multiplicity of steroid-inducible cytochromes P-450 in rat liver microsomes.
Highly Cited
1986
Highly Cited
1986
Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation
A cytochrome P-450 cDNA clone, designated pP450PCN2, homologous to the previously characterized pregnenolone 16 alpha… 
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