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Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner.
In vitro results were consistent with the observation in vivo that DZP N-demethylation and S-mephenytoin 4'-hydroxylation are closely correlated in humans and suggest that the apparent discrepancy on the role of CYP forms in D ZP metabolism in vitro and in vivo may reside in the difference in substrate concentration.
A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization.
- K. Sakamoto, S. Kirita, T. Matsubara
- Biology, ChemistryArchives of biochemistry and biophysics
- 10 June 1995
Western blot analysis suggested that P450 DUT2 is a constitutive and major (approximately 20% of the total P450) form, indicating that the 2D subfamily P450 in dog liver is quite unique from CYP2D members of other species.
Cytochrome P450 in livers of diabetic rats: regulation by growth hormone and insulin.
Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P‐450 human‐2
- T. Yasumori, N. Murayama, Y. Yamazoe, R. Kato
- Chemistry, BiologyClinical pharmacology and therapeutics
- 1 March 1990
Findings indicate the close relationship between polymorphic mephenytoin 4′‐hydroxylation and two stereospecific hexobarbital hydroxylations, and suggest that P‐450 human‐2 is a typical S‐(+)‐mephenytoin4′‐Hydroxylase and a major hexobar bital 3′-hydroxyase in the livers of extensive metabolizers.
Isolation and expression of a cDNA encoding a male-specific rat sulfotransferase that catalyzes activation of N-hydroxy-2-acetylaminofluorene.
EFFECT OF STARVATION ON NADPH-DEPENDENT ENZYMES IN LIVER MICROSOMES OF MALE AND FEMALE RATS
Although liver microsomes from male rats metabolize most drugs more rapidly than do those from female rats, the magnitude of the sex difference varies markedly with the substrate and the effects of starvation of male rats range from impairment of sex-dependent enzymes which metabolize aminopyrine and hexobarbital to enhancement of thesex-independent enzyme that hydroxylates aniline.
Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates.
Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity.
Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: difference in chiral preference of CYP2C9 and CYP2C19.
Hepatic triiodothyronine sulfation and its regulation by growth hormone and triiodothyronine in rats.
The data obtained raise the possibility that GH may modify the effect of thyroid hormones on the pituitary by a feed-back mechanism through changing the level of a sex-dominant phenol sulfotransferase(s) in rat livers.