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Antimitotic Agents

Known as: mitotic inhibitor, Mitosis Inhibitors, Mitosis Inhibitor Drugs 
An agent that inhibits tumor growth by interfering with mitotic processes or the assembly of the mitotic machinery.
National Institutes of Health

Related topics

Related topics

11 relations
Antifungal AgentsIn BloodMitosisMutagens

Broader (1)

Antimetabolites

Narrower (3)

ColchicineTaxanesrazoxane

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
A new antimitotic substance, FR182877. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
Using the characteristic morphological changes of mammalian cells, we screened novel antimitotic substances and found that a… 
Highly Cited
2000
Highly Cited
2000
A new antimitotic substance, FR182877. II. The mechanism of action.
Although antitumor drugs such as DNA synthesis inhibitors and antimitotic agents (microtubule modulators) have played important… 
2000
2000
A new antimitotic substance, FR182877. III. Structure determination.
During the course of screening for novel cell cycle inhibitors, FR182877 was isolated from the fermentation broth of Streptomyces… 
Highly Cited
1991
Highly Cited
1991
A new screening test for antimitotic compounds using the universal M phase-specific protein kinase, p34cdc2/cyclin Bcdc13, affinity-immobilized on p13suc1-coated microtitration plates.
A universal intracellular factor, the "M phase-Promoting Factor" (MPF), triggers the G2/M transition of the cell cycle in all… 
Highly Cited
1986
Highly Cited
1986
Distribution of microtubules during the breakdown of the nuclear envelope of the Xenopus oocyte: an immunocytochemical study
Xenopus oocytes were stained by anti‐tubulin and anti‐MAP1 antibodies during the first meiotic cell division. In the prophase… 
1983
1983
Effect of tamoxifen and alpha-difluoromethylornithine on clones of nitrosomethylurea-induced rat mammary tumor cells grown in soft agar culture.
N-Nitrosomethylurea-induced mammary tumors were grown in a bilayer soft-agar culture system. The antiestrogen tamoxifen prevented… 
1981
1981
Control of cell division of the intracellular Chlorella symbionts in green Hydra.
Green hydra maintains within its digestive cells a population of symbiotic algae which remains constant in normal culture… 
1973
1973
Enumeration of activated thymus-derived lymphocytes by the virus plaque assay.
Lymphocytes activated by antigens or mitogens acquire the capacity to replicate viruses, and the number of activated lymphocytes… 
1965
1965
The effect of an epidermis-specific mitotic inhibitor (chalone) extracted from epidermal cells.
Highly Cited
1963
Highly Cited
1963
Studies on the Antimitotic Activity of Leurocristine (Vincristine)
The effect of leurocristine (vincristine) on cell division was studied in normal bone marrow and leukemic cells (L1210 leukemia… 
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