Antimitotic Agents

Known as: mitotic inhibitor, Mitosis Inhibitors, Mitosis Inhibitor Drugs 
An agent that inhibits tumor growth by interfering with mitotic processes or the assembly of the mitotic machinery.
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Vinca alkaloids have been approved as anticancer drugs for more than 50 years. They have been classified as cytotoxic… (More)
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Highly Cited
2012
Highly Cited
2012
Cytotoxic cancer chemotherapy drugs are believed to gain selectivity by targeting cells that proliferate rapidly. However, the… (More)
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Highly Cited
2008
Highly Cited
2008
Drugs targeting the mitotic spindle are used extensively during chemotherapy, but surprisingly, little is known about how they… (More)
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Highly Cited
2008
Highly Cited
2008
To improve cancer chemotherapy, we need to understand the mechanisms that determine drug sensitivity in cancer and normal cells… (More)
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Highly Cited
2005
Highly Cited
2005
E7389, which is in phase I and II clinical trials, is a synthetic macrocyclic ketone analogue of the marine sponge natural… (More)
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Highly Cited
1999
Highly Cited
1999
Neural stem cells reside in the subventricular zone (SVZ) of the adult mammalian brain. This germinal region, which continually… (More)
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Highly Cited
1997
Highly Cited
1997
In the present study, we report the characterization of the p53 tumor suppressor pathway in the 60 cell lines of the National… (More)
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Highly Cited
1995
Highly Cited
1995
screen of the microscope. Between 150 to 300 nerve fibers were analyzed per cross section. 13. C. F. Eldridge, M. Bartlett, R. P… (More)
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Highly Cited
1990
Highly Cited
1990
A series of chalcones was evaluated as antimitotic agents. One of these, (E)-1-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl… (More)
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Highly Cited
1986
Highly Cited
1986
In the fission yeast S. pombe the cdc25+ gene function is required to initiate mitosis. We have cloned the cdc25+ gene and have… (More)
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