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Taxanes

Known as: Taxane Compound, taxane 
A type of drug that blocks cell growth by stopping mitosis (cell division). Taxanes interfere with microtubules (cellular structures that help move… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antimitotic AgentsTaxoids

Narrower (1)

Taxanes, antineoplastic

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Inhibition of Ovarian Cancer Growth by a Tumor-Targeting Peptide That Binds Eukaryotic Translation Initiation Factor 4E
Purpose: A critical step of protein synthesis involves the liberation of the mRNA cap-binding translation initiation factor eIF4E… 
Highly Cited
2007
Highly Cited
2007
Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes.
PURPOSE Ixabepilone is an epothilone B analog that binds to microtubules and results in microtubule stabilization and mitotic… 
Highly Cited
2007
Highly Cited
2007
Complete regression of xenografted human carcinomas by a paclitaxel-carboxymethyl dextran conjugate (AZ10992).
Highly Cited
2005
Highly Cited
2005
Antivascular Therapy for Orthotopic Human Ovarian Carcinoma through Blockade of the Vascular Endothelial Growth Factor and Epidermal Growth Factor Receptors
Purpose: We determined whether the administration of the tyrosine kinase inhibitor, AEE788, which targets the epidermal growth… 
Review
2003
Review
2003
Drug resistance reversal--are we getting closer?
Highly Cited
2003
Highly Cited
2003
Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata.
Highly Cited
2001
Highly Cited
2001
A phase I trial of doxorubicin, paclitaxel, and valspodar (PSC 833), a modulator of multidrug resistance.
PURPOSE P-glycoprotein is an efflux pump for many drugs including doxorubicin and paclitaxel. This study evaluated the… 
Review
1996
Review
1996
Major vault protein LRP-related multidrug resistance.
Highly Cited
1993
Highly Cited
1993
A highly efficient route to taxotere by the β-Lactam Synthon Method
Highly Cited
1981
Highly Cited
1981
19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana.
Activity-guided, chromatographic fractionation for a polar extract of Taxus wallichiana Zucc. (originally identified as… 
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