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Taxanes

Known as: Taxane Compound, taxane 
A type of drug that blocks cell growth by stopping mitosis (cell division). Taxanes interfere with microtubules (cellular structures that help move… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antimitotic AgentsTaxoids

Narrower (1)

Taxanes, antineoplastic

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer.
Review
2008
Review
2008
Is class III beta-tubulin a predictive factor in patients receiving tubulin-binding agents?
Highly Cited
2007
Highly Cited
2007
Limited Tissue Penetration of Taxanes: A Mechanism for Resistance in Solid Tumors
Purpose: Limited drug penetration in solid tumors is a potential mechanism of resistance for many anticancer drugs. Taxanes… 
Highly Cited
2006
Highly Cited
2006
Platinum-based neoadjuvant chemotherapy and interval surgical cytoreduction for advanced ovarian cancer: a meta-analysis.
Highly Cited
2003
Highly Cited
2003
Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro.
Highly Cited
2000
Highly Cited
2000
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase.
The blockade of epidermal growth factor receptor (EGFR) function with monoclonal antibodies has major antiproliferative effects… 
Highly Cited
1999
Highly Cited
1999
Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers
Previous studies have demonstrated a synergistic interaction between rhuMAb HER2 and the cytotoxic drug cisplatin in human breast… 
Review
1999
Review
1999
Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death.
PURPOSE To analyze the available data concerning mechanisms of action of and mechanisms of resistance to the antitubulin agents… 
Review
1994
Review
1994
The taxane diterpenoids.
The structures of over 350 taxane diterpenoids are classified and presented with information on their plant source, yield… 
Review
1992
Review
1992
Taxol: the first of the taxanes, an important new class of antitumor agents.
The taxanes represent the first class of antimicrotubule agents with a new mechanism of cytotoxic action since the introduction… 
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