• Publications
  • Influence
Brine shrimp: a convenient general bioassay for active plant constituents.
Screening results with seed extracts of 41 species of Euphorbiaceae were compared with 9KB and 9PS cytotoxicities and the method is rapid, reliable, inexpensive, and convenient as an in-house general bioassay tool. Expand
The Use of Biological Assays to Evaluate Botanicals
The Department of Medicinal Chemistry and Molecular Pharmacology's laboratory has adopted four “bench top” bioassays which do not require higher animals to screen and direct the fractionation of botanical extracts in drug discovery efforts, and the results in applying these simple methods in the discovery of Annonaceous acetogenins will be presented. Expand
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.
Results reveal receptor-mediated Lyn activation as a relatively piceatannol-insensitive event that may contribute to receptor subunit phosphorylation and Syk activation but does not per se elicit cellular responses. Expand
Annonaceous acetogenins: recent progress.
The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae and exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Expand
Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor.
Piceatannol (3,4,3'5'-tetrahydroxy-trans-stilbene), a plant secondary natural product that had previously been identified as an antileukemic principle, has been shown to be an inhibitor ofExpand
Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata.
Bioactivity-directed fractionation of the seeds of Annona muricata L. (Annonaceae) resulted in the isolation of five new compounds, three of which are among the first cis mono-tetrahydrofuran ring acetogenins to be reported. Expand
Five new monotetrahydrofuran ring acetogenins from the leaves of Annona muricata.
Bioactivity-directed fractionation of the leaves of Annona muricata resulted in the isolation of annopentocins A, B, and C(3), and cis- and trans-annomuricin-D-ones (4, 5), and new mono-THF ring acetogenins bearing two flanking hydroxyls and an erythro-diol located between the THF and the ketolactone rings. Expand
Recent advances in Annonaceous acetogenins.
Hough most acetogenins have high potencies among several solid human tumour cells lines, some of the derivatives within the different structural types and some positional isomers show remarkable selectivities among certain cell lines, e.g. against prostate cancer (PC-3). Expand
Paw paw and cancer: annonaceous acetogenins from discovery to commercial products.
  • J. McLaughlin
  • Biology, Medicine
  • Journal of natural products
  • 4 July 2008
Activity-directed fractionation of the paw paw extracts led to the isolation and molecular characterization of over 50 unique annonaceous acetogenins, which indicated a myriad of potentially useful applications. Expand