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Integrated Genomic Analyses of Ovarian Carcinoma
A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed… Expand
High-resolution genome-wide mapping of genetic alterations in human glial brain tumors.
High-resolution genome-wide mapping of exact boundaries of chromosomal alterations should facilitate the localization and identification of genes involved in gliomagenesis and may characterize… Expand
Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas.
Gene expression profiling has proven useful in subclassification and outcome prognostication for human glial brain tumors. The analysis of biological significance of the hundreds or thousands of… Expand
Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line MES-SA.
The emergence of drug-resistant tumor cells is a major limiting factor in cancer chemotherapy. There is little information about the nature of such resistant variants among human cancer cell… Expand
Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells.
- C. Washington, G. Duran, M. C. Man, B. Sikic, T. Blaschke
- Biology, Medicine
- Journal of acquired immune deficiency syndromes…
- 1 November 1998
The anti-HIV protease inhibitors represent a new class of agents for treatment of HIV infection. Saquinavir, ritonavir, indinavir, and nelfinavir are the first drugs approved in this class and… Expand
Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death.
PURPOSE To analyze the available data concerning mechanisms of action of and mechanisms of resistance to the antitubulin agents, vinca alkaloids and taxanes, and more recently described compounds. … Expand
Gene expression patterns in ovarian carcinomas.
- M. Schaner, D. Ross, +23 authors B. Sikic
- Biology, Medicine
- Molecular biology of the cell
- 1 November 2003
We used DNA microarrays to characterize the global gene expression patterns in surface epithelial cancers of the ovary. We identified groups of genes that distinguished the clear cell subtype from… Expand
Detection of cell-affecting agents with a silicon biosensor.
Cellular metabolism is affected by many factors in a cell's environment. Given a sufficiently sensitive method for measuring cellular metabolic rates, it should be possible to detect a wide variety… Expand
NFKBIA deletion in glioblastomas.
- M. Bredel, D. Scholtens, +22 authors G. Harsh
- The New England journal of medicine
- 16 February 2011
BACKGROUND Amplification and activating mutations of the epidermal growth factor receptor (EGFR) oncogene are molecular hallmarks of glioblastomas. We hypothesized that deletion of NFKBIA (encoding… Expand