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The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria
TLDR
The results indicate that humans or animals with low or absent BCRP activity may be at increased risk for developing protoporphyria and diet-dependent phototoxicity and provide a striking illustration of the importance of drug transporters in protection from toxicity of normal food constituents. Expand
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.
TLDR
The apical localization in the epithelium of the small intestine and colon indicates a possible role of BCRP in the regulation of the uptake of p.o. delivered B CRP substrates by back-transport of substrate drugs entering from the gut lumen and is consistent with the hypothesis of a protective role ofBCRP for the fetus. Expand
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.
TLDR
It is found that even in cells selected for a low level of resistance, several MRP-related genes can be up-regulated simultaneously, and the need for gene-specific blocks in gene expression to define which transporter contributes to resistance in each resistant cell line is emphasized. Expand
Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene
TLDR
The complementary DNA for rat cmoat, a homolog of the human multidrug resistance gene (hMRP1), was isolated and shown to be expressed in the canalicular membrane of hepatocytes and likely accounts for the TR− phenotype. Expand
MRP3, an organic anion transporter able to transport anti-cancer drugs.
TLDR
MRP3 is an organic anion and multidrug transporter, like the GS-X pumps MRP1 and MRP2, and in Madin-Darby canine kidney II cells, MRP3 routes to the basolateral membrane and mediates transport of the organicAnion S-(2,4-dinitrophenyl-)glutathione toward the basoliateral side of the monolayer. Expand
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs.
TLDR
It is speculated that MRP5 might play a role in some cases of unexplained resistance to thiopurines in acute lymphoblastic leukemia and/or to antiretroviral nucleoside analogs in HIV-infected patients. Expand
Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy
TLDR
The topotecan resistance of cells overexpressingMrp4 and the polarized expression of Mrp4 in the choroid plexus and brain capillary endothelial cells indicate that Mr p4 has a dual role in protecting the brain from cytotoxins and suggest that the therapeutic efficacy of central nervous system-directed drugs that are Mrp3 substrates may be improved by developing Mrp 4 inhibitors. Expand
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.
TLDR
It is concluded that MRP is a plasma membrane drug-efflux pump that confers drug resistance in human lung carcinoma cells by generating a subline stably transfected with an expression vector containing MRP cDNA. Expand
The drug resistance-related protein LRP is the human major vault protein
TLDR
The cloning and chromosome localization of the gene coding for the LRP protein is described and the deduced LRP amino acid sequence shows 87.7% identity with the 104-kD rat major vault protein. Expand
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
TLDR
This report provides a mechanistic basis for resistance to polyglutamatable antifolates through an MRP-mediated drug extrusion. Expand
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