Colchicine

Known as: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide, Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-, Colchicin 
An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines… (More)
National Institutes of Health

Related topics

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47 relations

Narrower (23)

2-chloroacetyl-2-demethylthiocolchicine2-demethylspeciosine2-demethylthiocolchicine3-demethylthiocolchicine
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Broader (4)

AlkaloidsGout SuppressantsTropolonecycloheptane
Biliary cirrhosisCOLCHICINE 4 [hp_X] in 15 mL TRANSDERMAL GEL [COLCIGEL]Colchicine / ProbenecidColchicine:MCnc:Pt:Bld:Qn
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Papers overview

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Highly Cited
2013
Highly Cited
2013
Low-dose colchicine for secondary prevention of cardiovascular disease.
OBJECTIVES The objective of this study was to determine whether colchicine 0.5 mg/day can reduce the risk of cardiovascular… (More)
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Highly Cited
2010
Highly Cited
2010
High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison…
OBJECTIVE Despite widespread use of colchicine, the evidence basis for oral colchicine therapy and dosing in acute gout remains… (More)
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Highly Cited
2005
Highly Cited
2005
Colchicine as first-choice therapy for recurrent pericarditis: results of the CORE (COlchicine for REcurrent pericarditis) trial.
BACKGROUND Colchicine seems to be a good drug for treating recurrences of pericarditis after conventional treatment failure, but… (More)
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Highly Cited
2004
Highly Cited
2004
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
Microtubules are cytoskeletal polymers of tubulin involved in many cellular functions. Their dynamic instability is controlled by… (More)
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Highly Cited
1999
Highly Cited
1999
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton.
Soluble factors from serum such as lysophosphatidic acid (LPA) are thought to activate the small GTP-binding protein Rho based on… (More)
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Highly Cited
1997
Highly Cited
1997
A trial of three regimens for primary amyloidosis: colchicine alone, melphalan and prednisone, and melphalan, prednisone, and colchicine.
BACKGROUND Primary systemic amyloidosis is an uncommon disease characterized by the accumulation in vital organs of a fibrillar… (More)
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Highly Cited
1987
Highly Cited
1987
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.
Intrinsic and acquired multidrug resistance (MDR) is an important problem in cancer therapy. MDR in human KB carcinoma cells… (More)
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Highly Cited
1986
Highly Cited
1986
Colchicine in the prevention and treatment of the amyloidosis of familial Mediterranean fever.
To determine whether colchicine prevents or ameliorates amyloidosis in patients with familial Mediterranean fever, we followed… (More)
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Highly Cited
1978
Highly Cited
1978
Immunocytochemical localization of glutamic acid decarboxylase in neuronal somata following colchicine inhibition of axonal transport
The enzyme that synthesizes the neurotransmitter y-aminobutyric acid (GABA), glutamic acid decarboxylase (GAD), has been… (More)
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Highly Cited
1967
Highly Cited
1967
THE MECHANISM OF ACTION OF COLCHICINE
Colchicine forms a complex in vivo with a protein present in fertilized or unfertilized sea urchin eggs; similar binding was… (More)
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