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Colchicine

Known as: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide, Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-, Colchicin 
An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines… 
National Institutes of Health

Related topics

Related topics

45 relations

Narrower (21)

2-chloroacetyl-2-demethylthiocolchicine2-demethylspeciosine2-demethylthiocolchicine3-demethylthiocolchicine

Broader (4)

AlkaloidsGout SuppressantsTropolonecycloheptane
Biliary cirrhosisCOLCHICINE 4 [hp_X] in 15 mL TRANSDERMAL GEL [COLCIGEL]Colchicine / ProbenecidColchicine:MCnc:Pt:Bld:Qn

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1982
Highly Cited
1982
Polymerization of the tubulin-colchicine complex and guanosine 5'-triphosphate hydrolysis.
The tubulin-colchicine (1:1) complex was shown to be able to polymerize in vitro under the buffer conditions of microtubule… 
Highly Cited
1981
Highly Cited
1981
Changes in the circular dichroic spectrum of colchicine associated with its binding to tubulin.
Circular dichroism has been used to study the interaction of colchicine with the tubulin alpha beta dimer at 26 degrees C… 
1980
1980
Colchicine inhibits epidermal growth factor degradation in 3T3 cells.
Colchicine (2 microM) did not affect the initial rate of association of 125I-labeled epidermal growth factor (125I-EGF) to Swiss… 
Highly Cited
1979
Highly Cited
1979
Management of necrotizing vasculitis with colchicine. Improvement in patients with cutaneous lesions and Behcet's syndrome.
Six patients with necrotizing vasculitis were treated with oral colchicine as part of an open study. Four patients with cutaneous… 
Highly Cited
1979
Highly Cited
1979
Endogenous inhibitor of colchicine-tubulin binding in rat brain.
A competitive inhibitor of colchicine binding to tubulin has been found in rat brain. Most of the inhibitor is associated with… 
Highly Cited
1978
Highly Cited
1978
Sulfhydryls of platelet tubulin: their role in polymerization and colchicine binding.
Sulfhydryls and disulfides of platelet tubulin have been quantified, their accessibility and reactivity measured, and their role… 
Highly Cited
1977
Highly Cited
1977
Enhancement of the PGE1 response of macrophages by concanavalin A and colchicine.
The effect of concanavalin A (Con A) and colchicine on the prostaglandin E1 (PGE1)-mediated cyclic AMP generation in rat… 
1976
1976
Colchicine-sensitive structures and lymphocyte activation.
The possible modulatory role of microtubules or closely related colchicine-sensitive structures in the response of human… 
Highly Cited
1975
Highly Cited
1975
Local anesthetics affect transmembrane cytoskeletal control of mobility and distribution of cell surface receptors.
Tertiary amine local anesthetics facilitated concanavalin A-induced redistribution of lectin receptors on murine BALB/3T3 cells… 
1947
1947
Variations of the submicroscopic structure of the cortical layer of fertilized and parthenogenetic sea urchin eggs.
The authors have investigated the structural variations of the cortical layer of Psammechinus miliaris egg after fertilization or… 
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