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Colchicine

Known as: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide, Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-, Colchicin 
An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines… 
National Institutes of Health

Related topics

Related topics

45 relations

Narrower (21)

2-chloroacetyl-2-demethylthiocolchicine2-demethylspeciosine2-demethylthiocolchicine3-demethylthiocolchicine

Broader (4)

AlkaloidsGout SuppressantsTropolonecycloheptane
Biliary cirrhosisCOLCHICINE 4 [hp_X] in 15 mL TRANSDERMAL GEL [COLCIGEL]Colchicine / ProbenecidColchicine:MCnc:Pt:Bld:Qn

Papers overview

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1984
1984
Immobilization-dependent fluorescence of colchicine.
Colchicine fluoresces when bound to tubulin but not in water, dioxane, or benzene. The basis of the fluorescence has now been… 
Highly Cited
1981
Highly Cited
1981
Changes in the circular dichroic spectrum of colchicine associated with its binding to tubulin.
Circular dichroism has been used to study the interaction of colchicine with the tubulin alpha beta dimer at 26 degrees C… 
1980
1980
A quantitative analysis of tubulin-colchicine binding to microtubules.
The binding of the tubulin-colchicine complex to microtubules has been studied in conditions where copolymerisation, as observed… 
Highly Cited
1979
Highly Cited
1979
Management of necrotizing vasculitis with colchicine. Improvement in patients with cutaneous lesions and Behcet's syndrome.
Six patients with necrotizing vasculitis were treated with oral colchicine as part of an open study. Four patients with cutaneous… 
Highly Cited
1977
Highly Cited
1977
Enhancement of the PGE1 response of macrophages by concanavalin A and colchicine.
The effect of concanavalin A (Con A) and colchicine on the prostaglandin E1 (PGE1)-mediated cyclic AMP generation in rat… 
Highly Cited
1966
Highly Cited
1966
Effects of colchicine on nucleic acid metabolism during metamorphosis of Tenebrio molitor L. and in some mammalian tissues.
1. Administration of 10mug. of colchicine/pupa of the beetle Tenebrio molitor L. arrests its differentiation, the pupa remaining… 
1961
1961
Deoxycytidylate deaminase levels in regenerating rat liver.
Deoxycytidylate deaminase activity and net synthesis of deoxyribonucleic acid (DNA) in vivo were found to increase at… 
1960
1960
Triploid Rat Embryos and Other Chromosomal Deviants after Colchicine Treatment and Polyspermy
Austin and Braden1 have shown in their classic paper on polyspermy in the rat that dispermy leads to a triploid fertilized egg… 
Highly Cited
1951
Highly Cited
1951
Observations on inhibition of nucleic acid synthesis resulting from administration of nitrogen mustard, urethan,. colchicine, 2,6-diaminopurine, 8-azaguanine, potassium arsenite, and cortisone.
Using the technic of measuring the incorporation of formate carbon into nucleic acid purines of control and treated mice, data… 
1947
1947
Variations of the submicroscopic structure of the cortical layer of fertilized and parthenogenetic sea urchin eggs.
The authors have investigated the structural variations of the cortical layer of Psammechinus miliaris egg after fertilization or…