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Colchicine

Known as: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide, Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-, Colchicin 
An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines… Expand
National Institutes of Health

Papers overview

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Highly Cited
2019
Highly Cited
2019
BACKGROUND Experimental and clinical evidence support the role of inflammation in atherosclerosis and its complications… Expand
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Highly Cited
2004
Highly Cited
2004
Microtubules are cytoskeletal polymers of tubulin involved in many cellular functions. Their dynamic instability is controlled by… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Primary systemic amyloidosis is an uncommon disease characterized by the accumulation in vital organs of a fibrillar… Expand
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Highly Cited
1987
Highly Cited
1987
Intrinsic and acquired multidrug resistance (MDR) is an important problem in cancer therapy. MDR in human KB carcinoma cells… Expand
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Highly Cited
1986
Highly Cited
1986
To determine whether colchicine prevents or ameliorates amyloidosis in patients with familial Mediterranean fever, we followed… Expand
Highly Cited
1983
Highly Cited
1983
This experiment examines the notion that in the rat the hippocampal formation is an essential structure in the neurological… Expand
Highly Cited
1979
Highly Cited
1979
TAXOL (Fig. 1) was isolated from the plant Taxus brevifolia (western yew) by Wani et al., who reported that the molecule has… Expand
Highly Cited
1976
Highly Cited
1976
Chinese hamster ovary cells selected for resistance to colchicine display pleiotropic cross-resistance to a wide range of… Expand
Highly Cited
1967
Highly Cited
1967
The majority of the colchicine-3H bound by tissue culture cells (KB or Hela) was found to be present as a noncovalent complex… Expand
Highly Cited
1956
Highly Cited
1956
The method was developed for bone marrow of mice but is applicable to other tissues and other species of small mammals. Mice are… Expand