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Colchicine

Known as: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide, Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-, Colchicin 
An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines… Expand
National Institutes of Health

Related topics

Related topics

45 relations

Narrower (21)

2-chloroacetyl-2-demethylthiocolchicine2-demethylspeciosine2-demethylthiocolchicine3-demethylthiocolchicine
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Broader (4)

AlkaloidsGout SuppressantsTropolonecycloheptane
Biliary cirrhosisCOLCHICINE 4 [hp_X] in 15 mL TRANSDERMAL GEL [COLCIGEL]Colchicine / ProbenecidColchicine:MCnc:Pt:Bld:Qn
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Papers overview

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Highly Cited
2013
Highly Cited
2013
Low-dose colchicine for secondary prevention of cardiovascular disease.
OBJECTIVES The objective of this study was to determine whether colchicine 0.5 mg/day can reduce the risk of cardiovascular… Expand
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Highly Cited
2005
Highly Cited
2005
Colchicine in Addition to Conventional Therapy for Acute Pericarditis: Results of the COlchicine for acute PEricarditis (COPE) Trial
Background—Colchicine is effective and safe for the treatment and prevention of recurrent pericarditis and might ultimately serve… Expand
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Highly Cited
2004
Highly Cited
2004
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
Microtubules are cytoskeletal polymers of tubulin involved in many cellular functions. Their dynamic instability is controlled by… Expand
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Highly Cited
1997
Highly Cited
1997
A trial of three regimens for primary amyloidosis: colchicine alone, melphalan and prednisone, and melphalan, prednisone, and colchicine.
BACKGROUND Primary systemic amyloidosis is an uncommon disease characterized by the accumulation in vital organs of a fibrillar… Expand
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Highly Cited
1996
Highly Cited
1996
Treatment of 100 patients with primary amyloidosis: a randomized trial of melphalan, prednisone, and colchicine versus colchicine only.
PURPOSE A clinical trial designed to test whether treatment with melphalan, prednisone, and colchicine (MPC) is superior to… Expand
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Highly Cited
1987
Highly Cited
1987
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.
Intrinsic and acquired multidrug resistance (MDR) is an important problem in cancer therapy. MDR in human KB carcinoma cells… Expand
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Highly Cited
1987
Highly Cited
1987
Colchicine myopathy and neuropathy.
Although colchicine has been used for centuries, its neuromuscular toxicity in humans is largely unrecognized. In this report we… Expand
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Highly Cited
1979
Highly Cited
1979
Promotion of microtubule assembly in vitro by taxol
TAXOL (Fig. 1) was isolated from the plant Taxus brevifolia (western yew) by Wani et al., who reported that the molecule has… Expand
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Highly Cited
1976
Highly Cited
1976
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.
Chinese hamster ovary cells selected for resistance to colchicine display pleiotropic cross-resistance to a wide range of… Expand
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Highly Cited
1956
Highly Cited
1956
A colchicine, hypotonic citrate, squash sequence for mammalian chromosomes.
The method was developed for bone marrow of mice but is applicable to other tissues and other species of small mammals. Mice are… Expand
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