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Colchicine
Known as:
(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
, Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
, Colchicin
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An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines…
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National Institutes of Health
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Related topics
Related topics
45 relations
Narrower (21)
2-chloroacetyl-2-demethylthiocolchicine
2-demethylspeciosine
2-demethylthiocolchicine
3-demethylthiocolchicine
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Broader (4)
Alkaloids
Gout Suppressants
Tropolone
cycloheptane
Biliary cirrhosis
COLCHICINE 4 [hp_X] in 15 mL TRANSDERMAL GEL [COLCIGEL]
Colchicine / Probenecid
Colchicine:MCnc:Pt:Bld:Qn
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction.
J. Tardif
,
S. Kouz
,
+22 authors
F. Roubille
New England Journal of Medicine
2019
Corpus ID: 208062875
BACKGROUND Experimental and clinical evidence support the role of inflammation in atherosclerosis and its complications…
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Highly Cited
2004
Highly Cited
2004
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
R. Ravelli
,
B. Gigant
,
+4 authors
Marcel Knossow
Nature
2004
Corpus ID: 4351652
Microtubules are cytoskeletal polymers of tubulin involved in many cellular functions. Their dynamic instability is controlled by…
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Highly Cited
2003
Highly Cited
2003
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation.
M. Betts
,
J. Brenchley
,
+4 authors
R. Koup
JIM - Journal of Immunological Methods
2003
Corpus ID: 2101251
Highly Cited
1997
Highly Cited
1997
A trial of three regimens for primary amyloidosis: colchicine alone, melphalan and prednisone, and melphalan, prednisone, and colchicine.
R. Kyle
,
M. A. Gertz
,
+4 authors
T. Therneau
New England Journal of Medicine
1997
Corpus ID: 205037598
BACKGROUND Primary systemic amyloidosis is an uncommon disease characterized by the accumulation in vital organs of a fibrillar…
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Highly Cited
1987
Highly Cited
1987
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.
K. Ueda
,
C. Cardarelli
,
M. Gottesman
,
I. Pastan
Proceedings of the National Academy of Sciences…
1987
Corpus ID: 13048422
Intrinsic and acquired multidrug resistance (MDR) is an important problem in cancer therapy. MDR in human KB carcinoma cells…
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Highly Cited
1986
Highly Cited
1986
Colchicine in the prevention and treatment of the amyloidosis of familial Mediterranean fever.
D. Zemer
,
M. Pras
,
E. Sohar
,
M. Modan
,
S. Cabili
,
J. Gafni
New England Journal of Medicine
1986
Corpus ID: 24676891
To determine whether colchicine prevents or ameliorates amyloidosis in patients with familial Mediterranean fever, we followed…
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Highly Cited
1978
Highly Cited
1978
Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals
Å. Ljungdahl
,
T. Hökfelt
,
G. Nilsson
Neuroscience
1978
Corpus ID: 45734576
Highly Cited
1976
Highly Cited
1976
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.
R. Juliano
,
V. Ling
Biochimica et Biophysica Acta
1976
Corpus ID: 22502302
Highly Cited
1967
Highly Cited
1967
THE MECHANISM OF ACTION OF COLCHICINE
G. Borisy
,
E. Taylor
Journal of Cell Biology
1967
Corpus ID: 17996105
The majority of the colchicine-3H bound by tissue culture cells (KB or Hela) was found to be present as a noncovalent complex…
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Highly Cited
1956
Highly Cited
1956
A colchicine, hypotonic citrate, squash sequence for mammalian chromosomes.
C. E. Ford
,
J. Hamerton
Stain Technology
1956
Corpus ID: 38783580
The method was developed for bone marrow of mice but is applicable to other tissues and other species of small mammals. Mice are…
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