Colchicine

Known as: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide, Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-, Colchicin 
An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
OBJECTIVES The objective of this study was to determine whether colchicine 0.5 mg/day can reduce the risk of cardiovascular… (More)
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Highly Cited
2010
Highly Cited
2005
Highly Cited
2005
BACKGROUND Colchicine seems to be a good drug for treating recurrences of pericarditis after conventional treatment failure, but… (More)
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Highly Cited
2004
Highly Cited
2004
Microtubules are cytoskeletal polymers of tubulin involved in many cellular functions. Their dynamic instability is controlled by… (More)
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Highly Cited
1999
Highly Cited
1999
Soluble factors from serum such as lysophosphatidic acid (LPA) are thought to activate the small GTP-binding protein Rho based on… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Primary systemic amyloidosis is an uncommon disease characterized by the accumulation in vital organs of a fibrillar… (More)
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Highly Cited
1987
Highly Cited
1987
Intrinsic and acquired multidrug resistance (MDR) is an important problem in cancer therapy. MDR in human KB carcinoma cells… (More)
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Highly Cited
1986
Highly Cited
1986
To determine whether colchicine prevents or ameliorates amyloidosis in patients with familial Mediterranean fever, we followed… (More)
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Highly Cited
1978
Highly Cited
1978
The enzyme that synthesizes the neurotransmitter y-aminobutyric acid (GABA), glutamic acid decarboxylase (GAD), has been… (More)
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Highly Cited
1967
Highly Cited
1967
Colchicine forms a complex in vivo with a protein present in fertilized or unfertilized sea urchin eggs; similar binding was… (More)
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