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Colchicine

Known as: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide, Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-, Colchicin 
An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines… Expand
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
OBJECTIVES The objective of this study was to determine whether colchicine 0.5 mg/day can reduce the risk of cardiovascular… Expand
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Highly Cited
2005
Highly Cited
2005
Background—Colchicine is effective and safe for the treatment and prevention of recurrent pericarditis and might ultimately serve… Expand
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Highly Cited
2004
Highly Cited
2004
Microtubules are cytoskeletal polymers of tubulin involved in many cellular functions. Their dynamic instability is controlled by… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Primary systemic amyloidosis is an uncommon disease characterized by the accumulation in vital organs of a fibrillar… Expand
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Highly Cited
1996
Highly Cited
1996
PURPOSE A clinical trial designed to test whether treatment with melphalan, prednisone, and colchicine (MPC) is superior to… Expand
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Highly Cited
1987
Highly Cited
1987
Intrinsic and acquired multidrug resistance (MDR) is an important problem in cancer therapy. MDR in human KB carcinoma cells… Expand
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Highly Cited
1987
Highly Cited
1987
Although colchicine has been used for centuries, its neuromuscular toxicity in humans is largely unrecognized. In this report we… Expand
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Highly Cited
1979
Highly Cited
1979
TAXOL (Fig. 1) was isolated from the plant Taxus brevifolia (western yew) by Wani et al., who reported that the molecule has… Expand
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Highly Cited
1976
Highly Cited
1976
Chinese hamster ovary cells selected for resistance to colchicine display pleiotropic cross-resistance to a wide range of… Expand
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Highly Cited
1956
Highly Cited
1956
The method was developed for bone marrow of mice but is applicable to other tissues and other species of small mammals. Mice are… Expand
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