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Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate.
2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-adenine (Cl-F-ara-A) has activity against the P388 tumor in mice on several different schedules. Biochemical studies with a chronic myelogenousExpand
Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines.
Inefficiency of gene delivery, together with inadequate bystander killing, represent two major hurdles in the development of a toxin-mediated gene therapy for human malignancy. The product of theExpand
Carbamates in the chemotherapy of leukemia. VIII. Overall tracer studies on carbonyl-labeled urethan, methylene-labeled urethan, and methylene-labeled ethyl alcohol.
Summary Over-all tracer studies have been carried out on carbonyl- and methylene-labeled urethan, NaHC 14 O 3 , and methylene-labeled ethyl alcohol. The rate of expiration of C 14 following injectionExpand
Comparison of the mechanism of cytotoxicity of 2-chloro-9-(2-deoxy-2- fluoro-beta-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro- beta-D-ribofuranosyl)adenine, and
In an effort to understand biochemical features that are important to the selective antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine [Cl-F( upward arrow)-dAdo], weExpand
Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells.
Activation of purine nucleoside analogs by Escherichia coli purine nucleoside phosphorylase (PNP) is being evaluated as a suicide gene therapy strategy for the treatment of cancer. Because theExpand
6-Methylthioguanylic acid, a metabolite of 6-thioguanine.
Abstract Human epidermoid carcinoma (H. Ep. No. 2) cells, grown in culture in the presence of 6-thioguanine- 35 S or methionine[methyl- 14 C] plus unlabeled 6-thioguanine, contained a previouslyExpand
Metabolism and Metabolic Effects of Halopurine Nucleosides in Tumor Cells in Culture
Abstract Within a series of halo derivatives of adenosine, deoxyadenosine and arabinosyladenine attempts have been made to correlate structure with cytotoxicity, substrate activity for adenosineExpand
Regional nuclear fuel cycle centres: IAEA study project
Abstract A study project on regional nuclear fuel cycle centres was initiated by the International Atomic Energy Agency in 1975 to examine the economic, safety, safeguards and security aspects of aExpand
Inhibition of protein synthesis in vitro by cycloheximide and related glutarimide antibiotics.
Abstract Cycloheximide (actidione) and the related glutarimide antibiotics, E-73, streptovitacin A, and streptimidone, have been studied as inhibitors of protein synthesis in vitro; mouseExpand
Activity and Mechanism of Action of 6-Methylthiopurine Ribonucleoside in Cancer Cells Resistant to 6-Mercaptopurine
Activity and Mechanism of Action of 6-Methylthiopurine Ribonucleoside in Cancer Cells Resistant to 6-Mercaptopurine