W. Franke

Publications679
h-index134
Citations61,470
Highly Influential Citations1,357
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The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
Roland Mall, Werner W. Franke and Dorothea L. Schiller Division of Membrane Biology and Biochemistry institute of Cell and Tumor Biology German Cancer Research Center D-6900 Heidelberg, Federal… Expand
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Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies.
The authors have recently identified a new cytokeratin (CK) polypeptide, CK 20, whose expression is almost entirely confined to the gastric and intestinal epithelium, urothelium, and Merkel cells.… Expand
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Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles
A polypeptide of Mr 38,000 has been identified as a specific component of the membrane of presynaptic vesicles, using the monoclonal antibody SY38. This protein, which is acidic (isoelectric at… Expand
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Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque
Using antibodies and recombinant DNA techniques, we have identified plakophilin 2, a novel desmosomal plaque protein of M(r) 100,000 (estimated from SDS-PAGE), which is a member of the arm-repeat… Expand
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Hormonal doping and androgenization of athletes: a secret program of the German Democratic Republic government.
Several classified documents saved after the collapse of the German Democratic Republic (GDR) in 1990 describe the promotion by the government of the use of drugs, notably androgenic steroids, in… Expand
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Structure and assembly properties of the intermediate filament protein vimentin: the role of its head, rod and tail domains.
We have investigated the functional role of the non-helical end domains of vimentin on its assembly properties using truncated Xenopus and human recombinant proteins. Removal of the amino-terminal… Expand
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Plakoglobin: A protein common to different kinds of intercellular adhering junctions
We have established, by means of a monoclonal antibody and a cDNA clone, that a desmosomal polypeptide of Mr 83,000 also occurs at the plaques of other types of adhering junctions, including the… Expand
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Symplekin, a novel type of tight junction plaque protein
Using a monoclonal antibody we have identified and cDNA-cloned a novel type of protein localized, by light and electron microscopy, to the plaque associated with the cytoplasmic face of the tight… Expand
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Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation
Plakophilins are proteins of the armadillo family that function in embryonic development and in the adult, and when mutated can cause disease. We have ablated the plakophilin 2 gene in mice. The… Expand
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Microinjection of actin-binding proteins and actin antibodies demonstrates involvement of nuclear actin in transcription of lampbrush chromosomes
Nuclei of amphibian oocytes contain large amounts of actin, mostly in unpolymerized or short-polymer form. When antibodies to actin or actin-binding proteins (fragmin and the actin modulator from… Expand
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