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Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies.
TLDR
CK-20 positivity was seen in the vast majority of adenocarcinomas of the colon, mucinous ovarian tumors, transitional-cell and Merkel-cell carcinomas and frequently also in adenOCarcinoma of the stomach, bile system, and pancreas and most squamous cell carcinomas from other sites were essentially or completely negative.
Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque
TLDR
It is concluded that plakophilins 2a and 2b are basic nuclear proteins that in certain cell types additionally assemble with other proteins to form the desmosomal plaque and serve general nuclear functions as well as a function specific to many but not all desmosomes.
Hormonal doping and androgenization of athletes: a secret program of the German Democratic Republic government.
Several classified documents saved after the collapse of the German Democratic Republic (GDR) in 1990 describe the promotion by the government of the use of drugs, notably androgenic steroids, in
Structure and assembly properties of the intermediate filament protein vimentin: the role of its head, rod and tail domains.
TLDR
The functional role of the non-helical end domains of vimentin on its assembly properties using truncated Xenopus and human recombinant proteins suggests that assembly occurred by a principally similar mechanism involving the end-on-fusion or annealing of unit-length filaments.
Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation
TLDR
It is concluded that plakophilin 2 is important for the assembly of junctional proteins and represents an essential morphogenic factor and architectural component of the heart.
Symplekin, a novel type of tight junction plaque protein
TLDR
S symplekin is discussed as a representative of a group of dual residence proteins which occur and probably function in the nucleus as well as in the plaques exclusive for either tight junctions, adherens junications, or desmosomes.
Endocytosis of junctional cadherins in bovine kidney epithelial (MDBK) cells cultured in low Ca2+ ion medium
TLDR
The membrane domains of both kinds of junction are endocytosed during Ca2+ depletion but stay in different vesicle populations, emphasizing the selective interaction of the specific cadherins with their respective plaque and filament partners.
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