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Mutagens

Known as: Genotoxins, Mutagen 
Anything that causes a mutation (a change in the DNA of a cell). DNA changes caused by mutagens may harm cells and cause certain diseases, such as… 
National Institutes of Health

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1,3-butadiene1,3-dichloro-2-propanol1,3-dinitropyrene1,N(6)-ethenoadenine
Alkylating AgentsAntimitotic AgentsIntercalating AgentsMutagenesis Process

Broader (1)

Pharmaceutical Preparations

Papers overview

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Highly Cited
1993
Highly Cited
1993
DNA adduct-induced stabilization of slipped frameshift intermediates within repetitive sequences: implications for mutagenesis.
Chemical carcinogens such as the aromatic amide 2-acetylaminofluorene (AAF) are known to induce -1 frameshift mutation hotspots… 
Highly Cited
1987
Highly Cited
1987
The vinyl chloride-derived nucleoside, N2,3-ethenoguanosine, is a highly efficient mutagen in transcription.
N2,3-Ethenoguanine (N2,3-epsilon G) was recently identified in the liver of vinyl chloride-exposed rats. We have now synthesized… 
Highly Cited
1983
Highly Cited
1983
Mutagen treatment as a means for selecting immunogenic variants from otherwise poorly immunogenic malignant murine tumors.
The selection of nontumorigenic (tum-), highly immunogenic variants from four different tumorigenic but poorly immunogenic murine… 
Highly Cited
1983
Highly Cited
1983
In vitro binding of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline to dietary fibers.
The ability of three kinds of fiber to bind to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a potent bacterial mutagen formed… 
1981
1981
Exposure to carcinogenic chemicals and smoking increases urinary excretion of mutagens in humans.
Urine samples from a control population and from a population of chemical workers from two chemical plants near Florence, Italy… 
Highly Cited
1980
Highly Cited
1980
A sensitive hepatocyte-mediated assay for the metabolism of nitrosamines to mutagens for mammalian cells.
A sensitive cell-mediated assay has been developed for testing mutagenesis in Chinese hamster V79 cells by carcinogenic… 
Highly Cited
1977
Highly Cited
1977
Mutagen-nucleic acid intercalative binding: structure of a 9-aminoacridine: 5-iodocytidylyl(3'-5')guanosine crystalline complex.
9-Aminoacridine forms a crystalline complex with the dinucleoside monophosphate, 5-iodocytidylyl(3'-5')guanosine. We have solved… 
Highly Cited
1974
Highly Cited
1974
Induction of endoreduplication in cultured mammalian cells by some chemical mutagens.
Summary Chinese hamster cells treated with such chemical mutagens as 4-nitroquinoline 1-oxide, captan, acridine dyes, and Cytoxan… 
1973
1973
Induction of mitotic crossing over in Saccharomyces cerevisiae by breakdown products of dimethylnitrosamine, diethylnitrosamine, 1-naphthylamine and 2-naphthylamine formed by an in vitro…
Dimethylnitrosamine and diethylnitrosamine, two potent carcinogens, are nonmutagenic when tested directly in microorganisms… 
1956
1956
The influence of photoreactivating light on the type and frequency of tumors induced by ultraviolet radiation.
Summary Ultraviolet light, λ 2537 A, is a potent inducer of skin neoplasms in albino mice. This finding is contrary to reports in…