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Alkylating Agents

Known as: Agents, Alkylating, Alkylators, Alkylating Agent 
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are… 
National Institutes of Health

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Narrower (31)

1,2-DimethylhydrazineAcetoxyacetylaminofluoreneAmino Acid Chloromethyl KetonesAntineoplastic Agents, Alkylating
Alkylating Activity [MoA]AlkylationAntineoplastic AgentsCarcinogens

Broader (1)

Indicators and Reagents

Papers overview

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Highly Cited
1997
Highly Cited
1997
High dietary omega-6 polyunsaturated fatty acids drastically increase the formation of etheno-DNA base adducts in white blood cells of female subjects.
Lipid peroxidation generates reactive aldehydes such as trans-4-hydroxy-2-nonenal and malonaldehyde, which form promutagenic… 
Highly Cited
1996
Highly Cited
1996
Long-Term Complications of Treatment and Causes of Mortality After Hodgkin's Disease.
Review
1978
Review
1978
Patterns of resistance and therapeutic synergism among alkylating agents.
Alkylating anticancer drugs are varied in chemical structure, alkylating moieties, and likely mechanisms of cytotoxic activity… 
Highly Cited
1977
Highly Cited
1977
A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): utilization with a variety of mutagenic…
Highly Cited
1975
Highly Cited
1975
Molecular Mechanisms for Repair of DNA
Methylating agents may produce as many as nine alkylated purine and pyrimidine adducts in DNA, as well as forming… 
Highly Cited
1974
Highly Cited
1974
Increased protease levels in transformed cells: a casein overlay assay for the detection of plasminogen activator production.
Highly Cited
1974
Highly Cited
1974
The enhancement by caffeine of alkylation-induced cell death, mutations and chromosomal aberrations in Chinese hamster cells, as a result of inhibition of post-replication DNA repair.
Highly Cited
1971
Highly Cited
1971
Quantitative aspects of the repair of alkylated DNA in cultured mammalian cells. I. The effect on HeLa and Chinese hamster cell survival of alkylation of cellular macromolecules.
Highly Cited
1965
Highly Cited
1965
Molecular Mechanism of the Cytotoxic Action of Difunctional Alkylating Agents and of Resistance to this Action
Molecular Mechanism of the Cytotoxic Action of Difunctional Alkylating Agents and of Resistance to this Action 
Highly Cited
1958
Highly Cited
1958
Studies on fluorinated pyrimidines. IV. Effects on nucleic acid metabolism in vivo.
Summary 1.A study of the effects of fluorinated pyrimidines on nucleic acid biosynthesis has been carried out in suspensions of… 
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