Alkylating Agents

Known as: Agents, Alkylating, Alkylators, Alkylating Agent 
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1946-2017
020040019462016

Papers overview

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Highly Cited
2008
Highly Cited
2008
PURPOSE Bendamustine has shown clinical activity in patients with disease refractory to conventional alkylator chemotherapy. The… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the killing of tumor cells by alkylating… (More)
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Highly Cited
1999
Highly Cited
1999
DNA chip technology enables simultaneous examination of how approximately 6,200 Saccharomyces cerevisiae gene transcript levels… (More)
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Highly Cited
1996
Highly Cited
1996
Several non-physiologic agents such as radiation, oxidants and alkylating agents induce ligand-independent activation of numerous… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Chemotherapy combinations that include an alkylating agent and a platinum coordination complex have high response… (More)
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Highly Cited
1993
Highly Cited
1993
EMT-6 murine mammary tumor sublines highly resistant to cyclophosphamide, cis-diamminedichloro-platinum(II), or N,N',N… (More)
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Highly Cited
1991
Highly Cited
1991
The effect of O6-benzylguanine, O6-(p-chlorobenzyl)guanine, and O6-(p-methylbenzyl)guanine on the sensitivity of various human… (More)
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Highly Cited
1987
Highly Cited
1987
The risk of leukemia was evaluated in 9,170 2-or-more-year survivors of childhood cancer in the 13 institutions of the Late… (More)
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Highly Cited
1984
Highly Cited
1984
Twenty-nine patients with advanced refractory multiple myeloma were treated with intermittent high-dose dexamethasone in… (More)
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