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Alkylating Agents
Known as:
Agents, Alkylating
, Alkylators
, Alkylating Agent
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Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are…
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National Institutes of Health
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Related topics
Related topics
41 relations
Narrower (31)
1,2-Dimethylhydrazine
Acetoxyacetylaminofluorene
Amino Acid Chloromethyl Ketones
Antineoplastic Agents, Alkylating
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Alkylating Activity [MoA]
Alkylation
Antineoplastic Agents
Carcinogens
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Broader (1)
Indicators and Reagents
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
The problem of specificity and selectivity of alkylating cytostatics; studies on N-2-chloroethylamido-oxazaphosphorines
N. Brock
,
H. Hohorst
Zeitschrift für Krebsforschung
2004
Corpus ID: 28296054
a) N-2-chloroethylamido-oxazaphosphorines such as cyclophosphamide, ifosfamide and trofosfamide differ from “non-oxazaphosphorine…
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Highly Cited
1990
Highly Cited
1990
DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard.
T. Gourdie
,
K. Valu
,
+6 authors
W. A. Denny
Journal of Medicinal Chemistry
1990
Corpus ID: 22513820
A series of DNA-targeted aniline mustards have been prepared, and their chemical reactivity and in vitro and in vivo cytotoxicity…
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Review
1980
Review
1980
DNA as a target of alkylating carcinogens.
P. D. Lawley
British Medical Bulletin
1980
Corpus ID: 39416755
Highly Cited
1980
Highly Cited
1980
Efficiency of the adaptive response of Escherichia coli to alkylating agents
J. Cairns
Nature
1980
Corpus ID: 4334663
When cultures of Escherichia coli are exposed to a low level of the alkylating agent N-methyl-N′-nitro-N-nitrosoguanidine (MNNG…
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Highly Cited
1979
Highly Cited
1979
Mutagenesis by cytostatic alkylating agents in yeast strains of differing repair capacities.
A. Ruhland
,
M. Brendel
Genetics
1979
Corpus ID: 11132442
Reversion of two nulcear ochre nonsense alleles and cell inactivation induced by mono-, bi-, and tri-functional alkylating agents…
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1979
1979
Oncogenesis, mutagenesis, DNA damage, and cytotoxicity in cultured mammalian cells treated with alkylating agents.
A. R. Peterson
,
H. Peterson
,
C. Heidelberger
Cancer Research
1979
Corpus ID: 7044866
Mutation to 8-azaguanine resistance in Chinese hamster cells and cytotoxicity and production and repair of alkalilabile lesions…
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Highly Cited
1975
Highly Cited
1975
Potential bioreductive alkylating agents. 5. Antineoplastic activity of quinoline-5,8-diones, naphthazarins, and naphthoquinones.
A. Lin
,
B. Lillis
,
A. Sartorelli
Journal of Medicinal Chemistry
1975
Corpus ID: 24884160
A number of 2-chloromethyl and 2-bromomethyl derivatives of naphthoquinones, quinolinediones, and naphthazarins were designed and…
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Highly Cited
1974
Highly Cited
1974
Ascorbic acid and biological alkylating agents
J. Edgar
Nature
1974
Corpus ID: 4252567
THE dangers to health from nitrite in the environment generally, and its use in meat processing in particular, have been pointed…
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1967
1967
Role of sulphydryl groups in adenosine deaminase.
G. Ronca
,
C. Bauer
,
C. Rossi
European Journal of Biochemistry
1967
Corpus ID: 38722385
The reactivity and the role of sulphydryl groups in adenosine deaminase have been investigated. In the sodium dodecylsulphate…
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Review
1963
Review
1963
STUDIES RELATED TO MECHANISMS OF RESISTANCE TO BIOLOGICAL ALKYLATING AGENTS.
G. P. Wheeler
Cancer Research
1963
Corpus ID: 238041
Summary Several possible mechanisms of resistance to alkylating agents have been posed and discussed on the basis of presently…
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