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Alkylating Agents

Known as: Agents, Alkylating, Alkylators, Alkylating Agent 
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
BACKGROUND Selinexor, a selective inhibitor of nuclear export compound that blocks exportin 1 (XPO1) and forces nuclear… Expand
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Review
2012
Review
2012
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main… Expand
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Review
2008
Review
2008
Intrinsic or acquired chemoresistance to alkylating agents is a major cause of treatment failure in patients with malignant brain… Expand
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Highly Cited
2008
Highly Cited
2008
Purpose: Bendamustine has shown clinical activity in patients with disease refractory to conventional alkylator chemotherapy. The… Expand
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Highly Cited
2007
Highly Cited
2007
Autophagy is a lysosome-dependent degradative pathway frequently activated in tumor cells treated with chemotherapy or radiation… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation… Expand
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Highly Cited
2002
Highly Cited
2002
Aripiprazole is the first next-generation atypical antipsychotic with a mechanism of action that differs from currently marketed… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the killing of tumor cells by alkylating… Expand
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Highly Cited
1995
Highly Cited
1995
Abstract Objective: To evaluate the effect of cytotoxic chemotherapy on survival in patients with non-small cell lung cancer… Expand
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Highly Cited
1975
Highly Cited
1975
About 300 carcinogens and non-carcinogens of a wide variety of chemical types have been tested for mutagenicity in the simple… Expand
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