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Alkylating Agents

Known as: Agents, Alkylating, Alkylators, Alkylating Agent 
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are… 
National Institutes of Health

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Narrower (31)

1,2-DimethylhydrazineAcetoxyacetylaminofluoreneAmino Acid Chloromethyl KetonesAntineoplastic Agents, Alkylating
Alkylating Activity [MoA]AlkylationAntineoplastic AgentsCarcinogens

Broader (1)

Indicators and Reagents

Papers overview

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Highly Cited
2015
Highly Cited
2015
Alcohols as alkylating agents in heteroarene C–H functionalization
Redox processes and radical intermediates are found in many biochemical processes, including deoxyribonucleotide synthesis and… 
Highly Cited
1999
Highly Cited
1999
Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers
Previous studies have demonstrated a synergistic interaction between rhuMAb HER2 and the cytotoxic drug cisplatin in human breast… 
Highly Cited
1996
Highly Cited
1996
Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.
Several non‐physiologic agents such as radiation, oxidants and alkylating agents induce ligand‐independent activation of numerous… 
Highly Cited
1996
Highly Cited
1996
Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer.
BACKGROUND Individuals who had cancer in childhood are at higher risk of developing bone cancer than any other type of second… 
Review
1995
Review
1995
Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC.
Review
1995
Review
1995
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks.
Review
1994
Review
1994
In press
29. Cited by Tsuchiya, Kenzaburo: The relation of occupation to cancer, especially cancer of the lung. Cancer, 1965, 18, 136-144… 
Highly Cited
1991
Highly Cited
1991
Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP.
Review
1979
Review
1979
DNA glycosylases, endonucleases for apurinic/apyrimidinic sites, and base excision-repair.
Highly Cited
1972
Highly Cited
1972
Detection of chemical mutagens by the dominant lethal assay in the mouse.
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