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Alkylating Agents

Known as: Agents, Alkylating, Alkylators, Alkylating Agent 
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main… Expand
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Review
2007
Review
2007
O(6)-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense against alkylating agents that generate… Expand
Review
2006
Review
2006
The purpose of this perspective is to indicate the range of chemistries used in the manufacture of drug candidate molecules and… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits the killing of tumor cells by alkylating… Expand
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Highly Cited
1999
Highly Cited
1999
DNA chip technology enables simultaneous examination of how approximately 6,200 Saccharomyces cerevisiae gene transcript levels… Expand
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Highly Cited
1995
Highly Cited
1995
Abstract Objective: To evaluate the effect of cytotoxic chemotherapy on survival in patients with non-small cell lung cancer… Expand
Review
1990
Review
1990
  • D. Beranek
  • Mutation research
  • 1990
  • Corpus ID: 44774129
Alkylating agents, because of their ability to react directly with DNA either in vitro or in vivo, or following metabolic… Expand
Highly Cited
1989
Highly Cited
1989
THE clinical manifestations of Fanconi's anemia, an autosomal recessive disorder, include progressive pancytopenia, a… Expand
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Highly Cited
1984
Highly Cited
1984
Twenty-nine patients with advanced refractory multiple myeloma were treated with intermittent high-dose dexamethasone in… Expand