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Acetoxyacetylaminofluorene

Known as: N-Acetoxy-N-acetyl-2-aminofluorene, N Acetoxy 2 acetylaminofluorene, Acetamide, N-(acetyloxy)-N-9H-fluoren-2-yl- 
An alkylating agent that forms DNA ADDUCTS at the C-8 position in GUANINE, resulting in single strand breaks. It has demonstrated carcinogenic action… 
National Institutes of Health

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Alkylating Agents
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Papers overview

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Highly Cited
2006
Highly Cited
2006
Gold(I) catalyzed isomerization of 5-en-2-yn-1-yl acetates: an efficient access to acetoxy bicyclo[3.1.0]hexenes and 2-cycloalken-1-ones.
The gold(I) catalyzed rearrangement of 5-en-2-yn-1-yl acetates into functionalized acetoxy bicyclo[3.1.0]hexenes is described… 
Highly Cited
2000
Highly Cited
2000
New bioactive metabolites produced by Colletotrichum sp., an endophytic fungus in Artemisia annua
Highly Cited
1998
Highly Cited
1998
Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots.
The major mutational hot spots in human cancers occur at CpG sequences in the p53 gene. It is generally presumed that the… 
Highly Cited
1989
Highly Cited
1989
Induction of fos RNA by DNA-damaging agents.
We have found that a wide variety of DNA-damaging agents and heat shock increase fos RNA to different extents in Chinese hamster… 
Highly Cited
1986
Highly Cited
1986
Mutations activating human c-Ha-ras1 protooncogene (HRAS1) induced by chemical carcinogens and depurination.
In vitro modification of plasmids containing the human c-Ha-ras1 protooncogene (HRAS1) with the ultimate carcinogens N-acetoxy-2… 
Highly Cited
1984
Highly Cited
1984
Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo.
  • R. Gupta
  • Proceedings of the National Academy of Sciences…
  • 1984
  • Corpus ID: 22483575
We have examined the distribution of individual adducts in repetitive DNA sequences of rat liver in vivo after a single dose of… 
Highly Cited
1984
Highly Cited
1984
2-Acetylaminofluorene-modified probes for the indirect hybridocytochemical detection of specific nucleic acid sequences.
Highly Cited
1982
Highly Cited
1982
32P-postlabeling analysis of non-radioactive aromatic carcinogen--DNA adducts.
A newly developed enzymatic 32P-postlabeling method was applied to the analysis of DNA's containing non-radioactive arylamine… 
Highly Cited
1981
Highly Cited
1981
Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines
The ability to excise (repair) UV-induced pyrimidine dimers in Escherichia coli is not related to its ability to remove N-methyl… 
Highly Cited
1975
Highly Cited
1975
Mutagenicity of carcinogenic azo dyes and their derivatives.
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