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Acetoxyacetylaminofluorene

Known as: N-Acetoxy-N-acetyl-2-aminofluorene, N Acetoxy 2 acetylaminofluorene, Acetamide, N-(acetyloxy)-N-9H-fluoren-2-yl- 
An alkylating agent that forms DNA ADDUCTS at the C-8 position in GUANINE, resulting in single strand breaks. It has demonstrated carcinogenic action… Expand
National Institutes of Health

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Broader (1)

Alkylating Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Cytotoxic profile of natural and some modified bufadienolides from toad Rhinella schneideri parotoid gland secretion.
Cutaneous secretions of toad species are an important source of bufadienolides, compounds that exhibit interesting structural… Expand
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Highly Cited
2002
Highly Cited
2002
Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage.
The Rev3 gene of Saccharomyces cerevisiae encodes the catalytic subunit of DNA polymerase zeta that is implicated in mutagenic… Expand
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Highly Cited
2000
Highly Cited
2000
New bioactive metabolites produced by Colletotrichum sp., an endophytic fungus in Artemisia annua
In addition to ergosterol (I), 3 beta,5 alpha,6 beta-trihydroxyergosta-7,22-diene (II), 3 beta-hydroxy-ergosta-5-ene (III), 3-oxo… Expand
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Highly Cited
1998
Highly Cited
1998
Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots.
The major mutational hot spots in human cancers occur at CpG sequences in the p53 gene. It is generally presumed that the… Expand
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Highly Cited
1989
Highly Cited
1989
Induction of fos RNA by DNA-damaging agents.
We have found that a wide variety of DNA-damaging agents and heat shock increase fos RNA to different extents in Chinese hamster… Expand
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Highly Cited
1984
Highly Cited
1984
Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo.
We have examined the distribution of individual adducts in repetitive DNA sequences of rat liver in vivo after a single dose of… Expand
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1984
1984
2-Acetylaminofluorene-modified probes for the indirect hybridocytochemical detection of specific nucleic acid sequences.
A new approach is presented for the indirect hybridocytochemical localization of specific nucleic acid sequences in microscopic… Expand
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Highly Cited
1982
Highly Cited
1982
32P-postlabeling analysis of non-radioactive aromatic carcinogen--DNA adducts.
A newly developed enzymatic 32P-postlabeling method was applied to the analysis of DNA's containing non-radioactive arylamine… Expand
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1981
1981
Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines
The ability to excise (repair) UV-induced pyrimidine dimers in Escherichia coli is not related to its ability to remove N-methyl… Expand
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Highly Cited
1975
Highly Cited
1975
Mutagenicity of carcinogenic azo dyes and their derivatives.
The mutagenicity of N,N-dimethyl-4-aminoazobenzene and N-methyl-4-aminoazobenzene and their derivatives was shown on Salmonella… Expand
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