Skip to search formSkip to main contentSkip to account menu

Acetoxyacetylaminofluorene

Known as: N-Acetoxy-N-acetyl-2-aminofluorene, N Acetoxy 2 acetylaminofluorene, Acetamide, N-(acetyloxy)-N-9H-fluoren-2-yl- 
An alkylating agent that forms DNA ADDUCTS at the C-8 position in GUANINE, resulting in single strand breaks. It has demonstrated carcinogenic action… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (1)

Alkylating Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Mechanism of biochemical action of substituted 4-methylcoumarins. Part 11: Comparison of the specificities of acetoxy derivatives of 4-methylcoumarin and 4-phenylcoumarin to acetoxycoumarins: protein…
Highly Cited
1993
Highly Cited
1993
32P-postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys.
The 32P-postlabeling method was used to examine the adducts in DNA, polynucleotides, and mononucleotides reacted in vitro with… 
Highly Cited
1984
Highly Cited
1984
DNA binding spectrum of the carcinogen N-acetoxy-N-2-acetylaminofluorene significantly differs from the mutation spectrum.
Highly Cited
1983
Highly Cited
1983
Identification of DNA polymerases involved in DNA excision repair in diploid human fibroblasts.
Highly Cited
1981
Highly Cited
1981
Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines
The ability to excise (repair) UV-induced pyrimidine dimers in Escherichia coli is not related to its ability to remove N-methyl… 
Highly Cited
1981
Highly Cited
1981
A tryptophan-containing peptide recognizes and cleaves DNA at apurinic sites
Oligopeptides containing aromatic amino acids can preferentially form stacked complexes with single-stranded nucleic acids1,2… 
Highly Cited
1980
Highly Cited
1980
Plasminogen activator: Induction of synthesis by DNA damage
Highly Cited
1979
Highly Cited
1979
DNA-protein cross-linking by chemical carcinogens in mammalian cells.
The induction of DNA cross-linking in mammalian cells by various carcinogens was investigated by the method of alkaline elution… 
Highly Cited
1976
Highly Cited
1976
DNA excision-repair deficiency of human peripheral blood lymphocytes treated with chemical carcinogens.
Human peripheral blood lymphocytes stimulated with concanavalin A for 72 hr have a 10-fold greater capacity to repair DNA damage… 
Highly Cited
1975
Highly Cited
1975
The measurement of chemically-induced DNA repair synthesis in human cells by BND-cellulose chromatography.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)