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1,2-Dimethylhydrazine
Known as:
Hydrazomethane
, N,N'-Dimethylhydrazine
, 1,2-Dimethylhydrazine [Chemical/Ingredient]
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A compound used experimentally to induce tumors in animal models of carcinogenesis. In mice and rats, 1,2-dimethylhydrazine may induce carcinogenesis…
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National Institutes of Health
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Related topics
Related topics
11 relations
1,2-Dimethylhydrazine Dihydrochloride
In Blood
agonists
antagonists & inhibitors
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Broader (3)
Alkylating Agents
Carcinogens
Mutagens
Narrower (1)
sym-Dimethylhydrazine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.
A. Satoh
,
Cynthia S. Brace
,
+5 authors
S. Imai
Cell metabolism
2013
Corpus ID: 40404142
Review
2008
Review
2008
Mechanisms of leptin action and leptin resistance.
M. Myers
,
M. Cowley
,
H. Münzberg
Annual review of physiology
2008
Corpus ID: 7572231
The adipose tissue-derived hormone leptin acts via its receptor (LRb) in the brain to regulate energy balance and neuroendocrine…
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Highly Cited
2004
Highly Cited
2004
Formation of Projection Pathways from the Arcuate Nucleus of the Hypothalamus to Hypothalamic Regions Implicated in the Neural Control of Feeding Behavior in Mice
S. Bouret
,
S. Draper
,
R. Simerly
The Journal of Neuroscience
2004
Corpus ID: 16757460
The arcuate nucleus of the hypothalamus (ARH) is a critical component of forebrain pathways that regulate a variety of…
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Highly Cited
2001
Highly Cited
2001
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
T. Bisogno
,
L. Hanuš
,
+7 authors
V. Di Marzo
British journal of pharmacology
2001
Corpus ID: 405197
(−)‐Cannabidiol (CBD) is a non‐psychotropic component of Cannabis with possible therapeutic use as an anti‐inflammatory drug…
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Highly Cited
2001
Highly Cited
2001
A neural circuit for circadian regulation of arousal
G. Aston-Jones
,
Sheng Chen
,
Yan Zhu
,
M. Oshinsky
Nature Neuroscience
2001
Corpus ID: 907637
An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates…
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Review
2001
Review
2001
Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic
D. Blanchard
,
G. Griebel
,
R. Blanchard
Neuroscience & Biobehavioral Reviews
2001
Corpus ID: 7600933
Highly Cited
2000
Highly Cited
2000
Chemical characterization of leptin‐activated neurons in the rat brain
C. Elias
,
J. Kelly
,
+4 authors
J. Elmquist
The Journal of comparative neurology
2000
Corpus ID: 28728353
Leptin has profound effects on food intake, body weight, and neuroendocrine status. The lack of leptin results in hormonal and…
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Highly Cited
1994
Highly Cited
1994
Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice.
D. Dillehay
,
S. Webb
,
E. Schmelz
,
A. Merrill
The Journal of nutrition
1994
Corpus ID: 4480431
Sphingolipids are in all eukaryotic cells and modulate cell growth, differentiation, and transformation; however, little is known…
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Highly Cited
1990
Highly Cited
1990
Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds.
H. Sumiyoshi
,
M. Wargovich
Cancer research
1990
Corpus ID: 16956686
Organosulfur compounds (OSCs) present in garlic and onion oil have been shown to inhibit chemical carcinogenesis. In this study…
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Highly Cited
1977
Highly Cited
1977
Investigations into the metabolism and mode of action of the colon carcinogens 1,2‐dimethylhydrazine and azoxymethane
E. Fiala
Cancer
1977
Corpus ID: 21597425
Colon cancer can be induced reliably in rodents with 1,2‐dimethylhydrazine and azoxymethane (AOM). Our studies deal with the mode…
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