FAQ

1,2-Dimethylhydrazine

Known as: Hydrazomethane, N,N'-Dimethylhydrazine, 1,2-Dimethylhydrazine [Chemical/Ingredient] 
A compound used experimentally to induce tumors in animal models of carcinogenesis. In mice and rats, 1,2-dimethylhydrazine may induce carcinogenesis… (More)

Topic mentions per year

Topic mentions per year

1967-2017
05019672017

Related topics

Related topics

13 relations
1,2-Dimethylhydrazine DihydrochlorideIn Bloodadministration & dosageagonists
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Broader (3)

Alkylating AgentsCarcinogensMutagens

Narrower (1)

sym-Dimethylhydrazine

Related mentions per year

Related mentions per year

1939-2018
19401960198020002020
1,2-Dimethylhydrazine
agonists
Carcinogens
Mutagens
Alkylating Agents
chemical synthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice.
The arcuate nucleus of the hypothalamus (ARH) is a critical component of forebrain pathways that regulate a variety of… (More)
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Highly Cited
2001
Highly Cited
2001
A neural circuit for circadian regulation of arousal
An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates… (More)
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Highly Cited
2000
Highly Cited
2000
Chemical characterization of leptin-activated neurons in the rat brain.
Leptin has profound effects on food intake, body weight, and neuroendocrine status. The lack of leptin results in hormonal and… (More)
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Highly Cited
1999
Highly Cited
1999
Methylation profiling of CpG islands in human breast cancer cells.
CpG island hypermethylation is known to be associated with gene silencing in cancer. This epigenetic event is generally accepted… (More)
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Highly Cited
1998
Highly Cited
1998
Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation.
The present study was carried out to examine the chemopreventive effects of carotenoids such as fucoxanthin, lycopene and lutein… (More)
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Highly Cited
1994
Highly Cited
1994
Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice.
Sphingolipids are in all eukaryotic cells and modulate cell growth, differentiation, and transformation; however, little is known… (More)
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1990
1990
Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds.
Organosulfur compounds (OSCs) present in garlic and onion oil have been shown to inhibit chemical carcinogenesis. In this study… (More)
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1980
1980
Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats.
The epidemiologic patterns of large bowel cancer have implicated a diet high in beef as a risk factor. Another study has shown… (More)
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Highly Cited
1977
Highly Cited
1977
Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane.
Colon cancer can be induced reliably in rodents with 1,2-dimethylhydrazine and azoxymethane (AOM). Our studies deal with the mode… (More)
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Highly Cited
1973
Highly Cited
1973
Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine.
Thirty-four CF1 mice were given weekly s.c. injections of 20 mg of 1,2-dimethylhydrazine hydrochloride per kg; this treatment… (More)
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