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1,2-Dimethylhydrazine

Known as: Hydrazomethane, N,N'-Dimethylhydrazine, 1,2-Dimethylhydrazine [Chemical/Ingredient] 
A compound used experimentally to induce tumors in animal models of carcinogenesis. In mice and rats, 1,2-dimethylhydrazine may induce carcinogenesis… 
National Institutes of Health

Related topics

Related topics

11 relations
1,2-Dimethylhydrazine DihydrochlorideIn Bloodagonistsantagonists & inhibitors

Broader (3)

Alkylating AgentsCarcinogensMutagens

Narrower (1)

sym-Dimethylhydrazine

Papers overview

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Highly Cited
1983
Highly Cited
1983
Selenium inhibition of 1,2-dimethylhydrazine-induced colon carcinogenesis.
The inhibitory effect of selenium (Na2SeO3) on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male Sprague-Dawley… 
1983
1983
Structure-activity relationship amongst biliary acids showing comutagenic activity towards 1,2-dimethylhydrazine.
Secondary biliary acids act, in vitro, as co-mutagenic agents towards 1,2-dimethylhydrazine incubated in the presence of… 
Highly Cited
1981
Highly Cited
1981
Biochemical and clinical effects of selenium on dimethylhydrazine-induced colon cancer in rats.
The biochemical and clinical effects of selenium (Na2SeO3) on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male… 
Highly Cited
1981
Highly Cited
1981
In vivo kinetics of O6-methylguanine and 7-methylguanine formation and persistence in DNA of rats treated with symmetrical dimethylhydrazine.
The rates of appearance and removal of 7-methylguanine and O6-methylguanine in DNA from rat liver, kidney, and colon were… 
Highly Cited
1980
Highly Cited
1980
A double-blind study on the effects of differing purified cellulose and pectin fiber diets on 1,2-dimethylhydrazine-induced rat colonic neoplasia.
The incidence, distribution, size, and histopathology of colonic tumors induced by parenteral administration of 1,2… 
1979
1979
Ileal resection potentiates 1,2-dimethylhydrazine-induced colonic carcinogenesis.
The effect of colonic hyperplasia produced by resection of the distal third of the small bowel (DSBR) on the development of… 
1979
1979
Selective protective effect of butylated hydroxytoluene against 1,2-dimethylhydrazine carcinogenesis in BALB/c mice.
The effect of the antioxidant butylated hydroxytoluene (BHT) was determined in 1,2-dimethylhydrazine (DMH) colon carcinogenesis… 
1977
1977
Inhibition of 1,2-dimethylhydrazine metabolism by disulfiram.
1. The effects of disulfiram on the metabolism of 1,2-dimethylhydrazine were studied in CDF rats. 2. Treatment with disulfiram… 
Highly Cited
1976
Highly Cited
1976
Nitrogen intake and tumorigenesis in rats injected with 1,2-dimethylhydrazine.
Tumor incidence was studied in 1,2-dimethylhydrazine (DMH) injected male rats assigned at weaning to isoenergetic casein-sucorse… 
Highly Cited
1973
Highly Cited
1973
An experimental model for cancer of the colon and rectum. Intestinal carcinoma induced in the rat 1,2-dimethylhydrazine.
1,2-Dimethylhydrazine(DMH) was administered s.c. to a group of 20 inbred BD-IX rats at the dose of 15 mg/kg body weight, weekly… 
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