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Alkylating Activity [MoA]

Known as: Alkylating Activity 
 
National Institutes of Health

Papers overview

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2016
2016
The need to protect human spermatozoa from oxidative stress during assisted reproductive technology, has prompted a detailed… Expand
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2004
2004
SummaryThe disposition of cyclophosphamide and its alkylating metabolites was investigated in a group of myeloma patients with… Expand
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2004
2004
SummaryThe pharmacokinetics of alkylating activity were studied in 17 children treated i.v. with ifosfamide (IF) at 3 g/m2 as a 1… Expand
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1989
1989
In order to develop cytotoxic estrogens with a specific effect on hormone‐dependent mammary tumors, two 1,1,2‐triphenylbut‐1‐enes… Expand
1986
1986
Several 1,2-bis(arylsulfonyl)-1-methylhydrazines were synthesized and evaluated for antineoplastic activity against the L1210… Expand
1982
1982
Ten patients with brain tumors and indwelling ventricular reservoirs were pretreated with 5% to 10% dimethyl sulfoxide (DMSO… Expand
Highly Cited
1981
Highly Cited
1981
Mitomycin C and hyperthermia are both toxic to chronically hypoxic EMT6 tumor cells. Combinations of this drug and heat were… Expand
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Highly Cited
1979
Highly Cited
1979
Abstract 1 Plasma cyclophosphamide levels were estimated by gas-chromatography in seven patients following intravenous and oral… Expand
1976
1976
Abstract Twenty patients with unresectable cancer received ifosfamide as a 30 min i.v. infusion daily for 3 days. Dose limiting… Expand
Highly Cited
1971
Highly Cited
1971
The authors studied the alkylating activity in the blood serum of man and rats after administration of cyclophosphamide, and its… Expand