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Transcription-coupled DNA repair: two decades of progress and surprises
Finite cycles of TCR at naturally occurring non-canonical DNA structures might contribute to genomic instability and genetic disease.
Comparative gene expression profiles following UV exposure in wild-type and SOS-deficient Escherichia coli.
The time courses of expression of the genes surrounding the 26 documented lexA-regulated regions on the E. coli chromosome are reported here and several newly identified UV-responsive genes are discussed with respect to their possible roles in cellular recovery following exposure to UV irradiation.
Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair.
- B. Hwang, J. Ford, P. Hanawalt, G. Chu
- BiologyProceedings of the National Academy of Sciences…
- 19 January 1999
It is shown that p48 mRNA levels strongly depend on basal p53 expression and increase further after DNA damage in a p53-dependent manner, and this results identify p48 as the link between p53 and the nucleotide excision repair apparatus.
Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions.
This work has divided the SNF2 family into multiple subfamilies, each of which represents what it proposes to be a functionally and evolutionarily distinct group, and used the subfamily structure to predict the functions of some of the uncharacterized proteins in the SNf2 family.
Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene
Subpathways of nucleotide excision repair and their regulation
- P. Hanawalt
- 16 December 2002
Since rodents are used as surrogates for environmental cancer risk assessment, it is essential that it is understood how they differ from humans with respect to DNA repair and oncogenic responses to environmental genotoxins.
DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall
p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/orgadd45 Genes
Evidence is provided that Gadd45 affects chromatin remodelling of templates concurrent with DNA repair, thus indicating that gadd45 may participate in the coupling between chromatin assembly and DNA repair.
A phylogenomic study of DNA repair genes, proteins, and processes.