• Publications
  • Influence
The reaction of mono- and di-functional alkylating agents with nucleic acids.
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Interstrand cross-linking of DNA by difunctional alkylating agents.
Triethylenemelamine, which was reported by Lorkiewicz & Szybalski (1961) not to react with DNA, and butadiene dioxide, which contains an alkyl chain of four carbon atoms, have been shown to reactExpand
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DNA adducts from chemotherapeutic agents.
The guiding principle of early work was the hypothesis that the anti-cancer alkylating drugs acted through their ability to cross-link macromolecules essential for cell division. Not long afterwards,Expand
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FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES.
Prothidium caused gross loss of motility and clumping of all trypanosomes. Comparison of the findings for trypanosomes with those for other cells previously studied shows that T. Iewi8i iS veryExpand
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Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N'-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen
1. In neutral aqueous solution N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) yields salts of nitrocyanamide as u.v.-absorbing products. With cysteine, as found independently by Schulz & McCalla (1969),Expand
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The reaction of mustard gas with nucleic acids in vitro and in vivo.
Mustard gas [di-(2-chloroethyl) sulphide] and analogous alkylating agents produce a wide range of biological effects (cf. review by Boyland, 1948). Some ofthese effects, such as induction ofmutationsExpand
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Some chemical aspects of dose-response relationships in alkylation mutagenesis.
Abstract Alkylation of DNA can lead to induction of potentially miscoding groups (promutagenic) or potentially template-inactivating groups (lethal). The proportions of these are found to vary withExpand
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Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of
1. Methods were developed for analysis of alkylpurines, O2-alkylcytosines, and representative phosphotriesters [alkyl derivatives of thymidylyl(3'-5')thymidine], in DNA alkylated in vivo, usingExpand
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Historical origins of current concepts of carcinogenesis.
  • P. D. Lawley
  • Biology, Medicine
  • Advances in cancer research
  • 1994
The first attempts to understand the causes of cancer were based on generalizations of what might now be termed a "holistic" nature, and hereditary influences were recognized at an early stage; theseExpand
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EFFECTS OF ALKYLATING AGENTS ON T2 AND T4 BACTERIOPHAGES.
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