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Amino Acid Chloromethyl Ketones

Known as: Peptide Chloromethyl Ketones, Chloromethyl Ketones, Peptide, Amino Acid Chloromethyl Ketones [Chemical/Ingredient] 
Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the… 
National Institutes of Health

Related topics

Related topics

48 relations

Broader (2)

Alkylating AgentsSerine Proteinase Inhibitors
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Narrower (40)

N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketoneN-tert-butyloxycarbonyl-aspartyl (benzyl)chloromethylketoneNalpha-acetyllysine chloromethyl ketoneO-methylsuccinyl-alanyl-alanyl-valyl-chloromethyl ketone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Cu(I)-Catalyzed Synthesis of Furan-Substituted Allenes by Use of Conjugated Ene-yne Ketones as Carbene Precursors.
The synthesis of furan-substituted allenes using conjugated ene-yne ketones as carbene source has been developed. For this… 
2015
2015
Pd-catalyzed cross-coupling of terminal alkynes with ene-yne-ketones: access to conjugated enynes via metal carbene migratory insertion.
A novel strategy for alkyne-alkyne cross-coupling has been developed under the palladium catalysis. In this reaction, ene-yne… 
Highly Cited
2007
Highly Cited
2007
Transition-metal-catalyzed rearrangement of allenyl sulfides: a route to furan derivatives.
Allene chemistry has attracted considerable attention in recent years. In particular, the transition-metal-catalyzed reaction of… 
2007
2007
Indium and Gallium-Mediated Addition Reactions
Indium and gallium have emerged as useful metals in organic synthesis as a result of its intriguing chemical properties of… 
1992
1992
Inactivation of calpain by peptidyl fluoromethyl ketones.
The syntheses of Z-Leu-Leu-Tyr-CH2F (1) and Z-Tyr-Ala-CH2F (3) are described. The ability of Z-Leu-Leu-Tyr-CH2F (1) and Z-Leu-Tyr… 
1990
1990
Sequential cross-coupling reactions as a versatile synthetic tool
Abstract 
1986
1986
Inactivation of calpain I and calpain II by specificity-oriented tripeptidyl chloromethyl ketones.
Three new tripeptidyl chloromethyl ketones, Leu-Leu-XCH2Cl, with X representing Phe, Tyr, or Lys, were synthesized and their… 
1986
1986
Effect of the nitro group conformation on the rat liver microsomal metabolism and bacterial mutagenicity of 2- and 9-nitroanthracene.
The aerobic and hypoxic metabolism of 2-nitroanthracene (2-NA) and 9-nitroanthracene (9-NA), two components of diesel exhaust… 
1975
1975
Characterization of two steroidal ketones and two isoprenoid alcohols in dairy products.
Two steroidal ketones, delta-4-cholesten-3-one and delta-3,-5-cholestadiene-7-one, were isolated and identified for the first… 
1973
1973
Kinetics of the reaction of chymotrypsin A with peptide chloromethyl ketones in relation to its subsite specificity.