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Antineoplastic Agents, Alkylating

Known as: Alkylating Antineoplastic Agents, Alkylating Antineoplastic Drugs, [AN100] ANTINEOPLASTICS,ALKYLATING AGENTS 
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular… 
National Institutes of Health

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AltretamineAniline MustardBusulfanCarbazilquinone
In Bloodchemical synthesis

Papers overview

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Highly Cited
1997
Highly Cited
1997
Detection of DNA lesions induced by chemical mutagens using the single-cell gel electrophoresis (comet) assay. 2. Relationship between DNA migration and alkaline condition.
Highly Cited
1994
Highly Cited
1994
Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug E09.
BACKGROUND A novel bioreductive alkylating indoloquinone compound, E09 [3-hydroxy-5-aziridinyl-1-methyl-2-(1H-indole-4,7-indione… 
Highly Cited
1992
Highly Cited
1992
Selective mutation of codons 204 and 213 of the p53 gene in rat tumors induced by alkylating N-nitroso compounds.
Kidney and esophageal tumors induced by alkylating N-nitroso compounds in rats contain a high incidence (75-100%) of G----A… 
Highly Cited
1990
Highly Cited
1990
Elevated pentose cycle and glucuronyltransferase in daunorubicin-resistant P388 cells.
Anthracycline resistance of P388 daunorubicin-resistant cells cannot be accounted for merely by differences in drug uptake and… 
Highly Cited
1989
Highly Cited
1989
Distribution and activity of antineoplastic drugs in a tumor model.
Antineoplastic drugs can be effective in solid tumors only if they can penetrate several cell layers and retain their activity in… 
Review
1982
Review
1982
Enhancement of chemotherapy agents.
Highly Cited
1979
Highly Cited
1979
Subunit structure and peptide mapping of junctional and extrajunctional acetylcholine receptors from rat muscle.
We have purified the junctional acetylcholine receptor from normal rat skeletal muscle and compared its structure with that of… 
Review
1978
Review
1978
Patterns of resistance and therapeutic synergism among alkylating agents.
Alkylating anticancer drugs are varied in chemical structure, alkylating moieties, and likely mechanisms of cytotoxic activity… 
Highly Cited
1971
Highly Cited
1971
Metabolism of cyclophosphamide by rat hepatic microsomes.
Summary The conversion of cyclophosphamide to its alkylating metabolite(s) by microsomes obtained from male rat liver was… 
Highly Cited
1966
Highly Cited
1966
Teratogenic and Carcinogenic Effects in the Offspring after Single Injection of Ethylnitrosourea to Pregnant Rats
ALKYLNITROSOUREAS give the corresponding alkylating diazoalkanes on heterolysis, and are potent carcinogens, selectively… 
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