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Antineoplastic Agents, Alkylating
Known as:
Alkylating Antineoplastic Agents
, Alkylating Antineoplastic Drugs
, [AN100] ANTINEOPLASTICS,ALKYLATING AGENTS
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A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular…
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National Institutes of Health
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Related topics
Related topics
42 relations
Narrower (40)
Altretamine
Aniline Mustard
Busulfan
Carbazilquinone
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In Blood
chemical synthesis
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Pulmonary complications of novel antineoplastic agents for solid tumors.
B. Vahid
,
P. Marik
Chest
2008
Corpus ID: 207383566
Antineoplastic agent-induced pulmonary toxicity is an important cause of respiratory failure. Although the incidence of…
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Review
2006
Review
2006
Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response.
N. Festjens
,
T. Vanden Berghe
,
P. Vandenabeele
Biochimica et biophysica acta
2006
Corpus ID: 44490656
Highly Cited
2004
Highly Cited
2004
DNA binding and nucleotide flipping by the human DNA repair protein AGT
D. Daniels
,
T. T. Woo
,
+4 authors
J. Tainer
Nature Structural &Molecular Biology
2004
Corpus ID: 26072564
O6-alkylguanine-DNA alkyltransferase (AGT), or O6-methylguanine-DNA methyltransferase (MGMT), prevents mutations and apoptosis…
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Highly Cited
2001
Highly Cited
2001
Cysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones*
A. García-Piñeres
,
V. Castro
,
+4 authors
I. Merfort
The Journal of Biological Chemistry
2001
Corpus ID: 20191806
Sesquiterpene lactones (SLs) have potent anti-inflammatory properties. We have shown previously that they exert this effect in…
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Highly Cited
1997
Highly Cited
1997
Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C.
K. Das
,
C. White
The Journal of biological chemistry
1997
Corpus ID: 20101466
Paclitaxel can induce tumor necrosis factor (TNF) and interleukin-1 gene expression, similar to lipopolysaccharides. Since…
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Review
1990
Review
1990
Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.
A. Pegg
Cancer research
1990
Corpus ID: 18843385
Alkylating agents and compounds converted metabolically to alkylating agents form an important class of carcinogens and mutagens…
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Highly Cited
1989
Highly Cited
1989
Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms.
W. Mcguire
,
E. Rowinsky
,
+4 authors
R. Donehower
1989
Corpus ID: 71501492
Abstract Study Objective:To assess the activity of taxol in patients with advanced, progressive, and drug-refractory ovarian…
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Highly Cited
1985
Highly Cited
1985
Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents.
C. Hoy
,
L. Thompson
,
C. Mooney
,
E. Salazar
Cancer research
1985
Corpus ID: 21789573
DNA repair-deficient mutants from five genetic complementation groups isolated previously from Chinese hamster cells were assayed…
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Highly Cited
1979
Highly Cited
1979
Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA
P. Karran
,
T. Lindahl
,
B. Griffin
Nature
1979
Corpus ID: 4274209
THE mutagenic lesion O6-methylguanine (O6-MeG) is slowly but actively removed from DNA in Escherichia coli cells treated with…
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Review
1977
Review
1977
Formation and metabolism of alkylated nucleosides: possible role in carcinogenesis by nitroso compounds and alkylating agents.
A. Pegg
Advances in cancer research
1977
Corpus ID: 43066125
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