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Antineoplastic Agents, Alkylating

Known as: Alkylating Antineoplastic Agents, Alkylating Antineoplastic Drugs, [AN100] ANTINEOPLASTICS,ALKYLATING AGENTS 
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular… 
National Institutes of Health

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AltretamineAniline MustardBusulfanCarbazilquinone
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Papers overview

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Review
2008
Review
2008
Pulmonary complications of novel antineoplastic agents for solid tumors.
Antineoplastic agent-induced pulmonary toxicity is an important cause of respiratory failure. Although the incidence of… 
Review
2006
Review
2006
Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response.
Highly Cited
2004
Highly Cited
2004
DNA binding and nucleotide flipping by the human DNA repair protein AGT
O6-alkylguanine-DNA alkyltransferase (AGT), or O6-methylguanine-DNA methyltransferase (MGMT), prevents mutations and apoptosis… 
Highly Cited
2001
Highly Cited
2001
Cysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones*
Sesquiterpene lactones (SLs) have potent anti-inflammatory properties. We have shown previously that they exert this effect in… 
Highly Cited
1997
Highly Cited
1997
Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C.
  • K. Das, C. White
  • The Journal of biological chemistry
  • 1997
  • Corpus ID: 20101466
Paclitaxel can induce tumor necrosis factor (TNF) and interleukin-1 gene expression, similar to lipopolysaccharides. Since… 
Review
1990
Review
1990
Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.
  • A. Pegg
  • Cancer research
  • 1990
  • Corpus ID: 18843385
Alkylating agents and compounds converted metabolically to alkylating agents form an important class of carcinogens and mutagens… 
Highly Cited
1989
Highly Cited
1989
Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms.
Abstract Study Objective:To assess the activity of taxol in patients with advanced, progressive, and drug-refractory ovarian… 
Highly Cited
1985
Highly Cited
1985
Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents.
DNA repair-deficient mutants from five genetic complementation groups isolated previously from Chinese hamster cells were assayed… 
Highly Cited
1979
Highly Cited
1979
Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA
THE mutagenic lesion O6-methylguanine (O6-MeG) is slowly but actively removed from DNA in Escherichia coli cells treated with… 
Review
1977
Review
1977
Formation and metabolism of alkylated nucleosides: possible role in carcinogenesis by nitroso compounds and alkylating agents.
  • A. Pegg
  • Advances in cancer research
  • 1977
  • Corpus ID: 43066125
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