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Antineoplastic Agents, Alkylating

Known as: Alkylating Antineoplastic Agents, Alkylating Antineoplastic Drugs, [AN100] ANTINEOPLASTICS,ALKYLATING AGENTS 
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular… 
National Institutes of Health

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Narrower (40)

AltretamineAniline MustardBusulfanCarbazilquinone
In Bloodchemical synthesis

Papers overview

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Highly Cited
1997
Highly Cited
1997
Detection of DNA lesions induced by chemical mutagens using the single-cell gel electrophoresis (comet) assay. 2. Relationship between DNA migration and alkaline condition.
Highly Cited
1993
Highly Cited
1993
Antineoplastic agent doxorubicin inhibits myogenic differentiation of C2 myoblasts.
Highly Cited
1991
Highly Cited
1991
Rational design of quinazoline-based irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase.
Described herein is the rational design of irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase (PNPase… 
1990
1990
DNA repair mechanisms and their biologic implications in mammalian cells. Report of a NATO advanced research workshop, Fontevraud, France, Oct. 2-7, 1988.
Highly Cited
1989
Highly Cited
1989
Transcription-terminating lesions induced by bifunctional alkylating agents in vitro.
The present study was initiated to determine if DNA damage induced by the bifunctional anti-tumor alkylating agents melphalan… 
Highly Cited
1985
Highly Cited
1985
Effect of estramustine phosphate on the assembly of isolated bovine brain microtubules and fast axonal transport in the frog sciatic nerve.
Estramustine phosphate (0.01 to 0.5 mM), an estradiol mustard derivative used in the therapy of prostatic carcinoma, inhibited… 
Highly Cited
1979
Highly Cited
1979
Subunit structure and peptide mapping of junctional and extrajunctional acetylcholine receptors from rat muscle.
We have purified the junctional acetylcholine receptor from normal rat skeletal muscle and compared its structure with that of… 
Highly Cited
1975
Highly Cited
1975
Effect of a single treatment with the alkylating carcinogens dimethynitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy. I. Test for…
Highly Cited
1975
Highly Cited
1975
Effect of a single treatment with the alkylating carcinogens dimethylnitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy. II. Alkylation of…
Highly Cited
1967
Highly Cited
1967
The interaction of actinomycin with DNA: requirement for the 2-amino group of purines.
The formation of complexes between actinomycin (AM) (Fig. 1) and DNA is known to depend on specific structures in both the… 
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