Antineoplastic Agents, Alkylating

Known as: Alkylating Antineoplastic Agents, Alkylating Antineoplastic Drugs, [AN100] ANTINEOPLASTICS,ALKYLATING AGENTS 
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular… (More)
National Institutes of Health

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AltretamineAniline MustardBusulfanCarbazilquinone
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In Bloodchemical synthesis

Papers overview

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Highly Cited
2009
Highly Cited
2009
O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors.
PURPOSE Recent studies suggest that temozolomide has activity in neuroendocrine tumors. Low levels of the DNA repair enzyme, O(6… (More)
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Review
2008
Review
2008
Pulmonary complications of novel antineoplastic agents for solid tumors.
Antineoplastic agent-induced pulmonary toxicity is an important cause of respiratory failure. Although the incidence of… (More)
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Highly Cited
2008
Highly Cited
2008
Aluminium induced oxidative stress and DNA damage in root cells of Allium cepa L.
Aluminium (Al) was evaluated for induction of oxidative stress and DNA damage employing the growing roots of Allium cepa L. as… (More)
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Highly Cited
2007
Highly Cited
2007
Quantitative assessment of the impact of chemotherapy on ovarian follicle reserve and stromal function.
BACKGROUND Various chemotherapy agents, especially of the alkylating category, have been associated with premature ovarian… (More)
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Review
2004
Review
2004
Thioredoxin and its role in toxicology.
Thioredoxins (Trx) are members of an evolutionarily conserved family of redox-active proteins containing a conserved active site… (More)
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Highly Cited
2004
Highly Cited
2004
DNA binding and nucleotide flipping by the human DNA repair protein AGT
O6-alkylguanine-DNA alkyltransferase (AGT), or O6-methylguanine-DNA methyltransferase (MGMT), prevents mutations and apoptosis… (More)
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Highly Cited
2001
Highly Cited
2001
Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones.
Sesquiterpene lactones (SLs) have potent anti-inflammatory properties. We have shown previously that they exert this effect in… (More)
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Review
1990
Review
1990
Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.
Alkylating agents and compounds converted metabolically to alkylating agents form an important class of carcinogens and mutagens… (More)
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Highly Cited
1987
Highly Cited
1987
High-dose chemoradiotherapy and autologous bone marrow transplantation for resistant multiple myeloma.
Seven patients with advanced multiple myeloma, refractory to therapy with alkylating agent-VAD (vincristine-adriamycin… (More)
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Highly Cited
1985
Highly Cited
1985
Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents.
DNA repair-deficient mutants from five genetic complementation groups isolated previously from Chinese hamster cells were assayed… (More)
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