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Antineoplastic Agents, Alkylating

Known as: Alkylating Antineoplastic Agents, Alkylating Antineoplastic Drugs, [AN100] ANTINEOPLASTICS,ALKYLATING AGENTS 
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Cancer is considered as one of the most serious health problems today. The discovery of nitrogen mustard as an alkylating agent… Expand
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Review
2006
Review
2006
Necrosis has long been described as a consequence of physico-chemical stress and thus accidental and uncontrolled. Recently, it… Expand
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Highly Cited
2004
Highly Cited
2004
O6-alkylguanine-DNA alkyltransferase (AGT), or O6-methylguanine-DNA methyltransferase (MGMT), prevents mutations and apoptosis… Expand
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Highly Cited
2001
Highly Cited
2001
Sesquiterpene lactones (SLs) have potent anti-inflammatory properties. We have shown previously that they exert this effect in… Expand
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Review
1990
Review
1990
  • A. Pegg
  • Cancer research
  • 1990
  • Corpus ID: 18843385
Alkylating agents and compounds converted metabolically to alkylating agents form an important class of carcinogens and mutagens… Expand
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Highly Cited
1989
Highly Cited
1989
Abstract Study Objective:To assess the activity of taxol in patients with advanced, progressive, and drug-refractory ovarian… Expand
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Highly Cited
1985
Highly Cited
1985
DNA repair-deficient mutants from five genetic complementation groups isolated previously from Chinese hamster cells were assayed… Expand
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Highly Cited
1979
Highly Cited
1979
THE mutagenic lesion O6-methylguanine (O6-MeG) is slowly but actively removed from DNA in Escherichia coli cells treated with… Expand
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Review
1977
Review
1977
  • A. Pegg
  • Advances in cancer research
  • 1977
  • Corpus ID: 43066125
Publisher Summary Alkylation of nucleic acids occurs both physiologically within living cells and after the administration of… Expand
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Highly Cited
1966
Highly Cited
1966
ALKYLNITROSOUREAS give the corresponding alkylating diazoalkanes on heterolysis, and are potent carcinogens, selectively… Expand
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