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Antineoplastic Agents, Alkylating

Known as: Alkylating Antineoplastic Agents, Alkylating Antineoplastic Drugs, [AN100] ANTINEOPLASTICS,ALKYLATING AGENTS 
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular… 
National Institutes of Health

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AltretamineAniline MustardBusulfanCarbazilquinone
In Bloodchemical synthesis

Papers overview

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2009
2009
Comparison of the cytotoxic effect of prednimustine in cultured cells with high or low levels of metallothionein.
The purpose of this investigation was to evaluate the ability of the cysteinyl-rich protein metallothionein (MT) to protect cells… 
2004
2004
Antitumour effect of a- and d- lactam androgen nitrogen mustards on non-small cell lung carcinoma.
PURPOSE We tested 3 alkylating esters of D-lactam androsterone, 3 alkylating esters of A-lactam testosterone and the alkylating… 
1994
1994
Free alpha subunit of human chorionic gonadotrophin: molecular basis of immunologically and biologically active domains.
Immunochemical studies were undertaken to identify surface-orientated epitopes of the free alpha subunit of human chorionic… 
1985
1985
Effect of alkylation of tryptophan residues on the enzymatic and pharmacological properties of snake venom phospholipase A2.
Snake venom phospholipases A2 show a remarkable degree of amino acid sequence homology yet differ markedly in enzymatic and… 
1982
1982
Sister chromatid exchange induced by short-lived monoadducts produced by the bifunctional agents mitomycin C and 8-methoxypsoralen.
To see if DNA crosslinks are involved in the induction of sister chromatid exchange (SCE), Chinese hamster ovary cells were… 
1978
1978
Chemotherapeutic activity of new 2-chloroethylnitrosoureas in rat L5222 leukemia: comparison of bifunctional and water-soluble derivatives with 1,3-bis(2-chloroethyl)-1-nitrosourea.
The chemotherapeutic activity of eight nitrosourea derivatives was compared with that of 1,3-bis(2-chloroethyl)-1-nitrosourea… 
Review
1976
Review
1976
Repair excision of alkylated bases from DNA in vivo.
Recent experiments are reviewed which indicate that O6-alkylation of guanine in nuclear DNA constitutes a promutagenic lesion… 
1973
1973
Cellular reactions of O6-methylguanine, a product of some alkylating carcinogens.
Cultures of a purine-requiring mutant of Chinese hamster ovary cells (CHO-104b), randomly bred hamster embryo cells, or… 
Highly Cited
1967
Highly Cited
1967
The interaction of actinomycin with DNA: requirement for the 2-amino group of purines.
The formation of complexes between actinomycin (AM) (Fig. 1) and DNA is known to depend on specific structures in both the… 
1967
1967
Effects of antitumor agents on the synthesis of nucleolar DNA.
Summary In studies on labeling of DNA by tritiated thymidine, it was found that extranucleolar DNA was labeled more rapidly than…