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Antineoplastic Agents, Alkylating

Known as: Alkylating Antineoplastic Agents, Alkylating Antineoplastic Drugs, [AN100] ANTINEOPLASTICS,ALKYLATING AGENTS 
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular… Expand
National Institutes of Health

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AltretamineAniline MustardBusulfanCarbazilquinone
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In Bloodchemical synthesis

Papers overview

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Review
2018
Review
2018
Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives.
Cancer is considered as one of the most serious health problems today. The discovery of nitrogen mustard as an alkylating agent… Expand
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Review
2006
Review
2006
Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response.
Necrosis has long been described as a consequence of physico-chemical stress and thus accidental and uncontrolled. Recently, it… Expand
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Highly Cited
2004
Highly Cited
2004
DNA binding and nucleotide flipping by the human DNA repair protein AGT
O6-alkylguanine-DNA alkyltransferase (AGT), or O6-methylguanine-DNA methyltransferase (MGMT), prevents mutations and apoptosis… Expand
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Highly Cited
2001
Highly Cited
2001
Cysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones*
Sesquiterpene lactones (SLs) have potent anti-inflammatory properties. We have shown previously that they exert this effect in… Expand
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Review
1990
Review
1990
Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.
  • A. Pegg
  • Cancer research
  • 1990
    • Corpus ID: 18843385
Alkylating agents and compounds converted metabolically to alkylating agents form an important class of carcinogens and mutagens… Expand
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Highly Cited
1989
Highly Cited
1989
Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms.
Abstract Study Objective:To assess the activity of taxol in patients with advanced, progressive, and drug-refractory ovarian… Expand
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Highly Cited
1985
Highly Cited
1985
Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents.
DNA repair-deficient mutants from five genetic complementation groups isolated previously from Chinese hamster cells were assayed… Expand
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Highly Cited
1979
Highly Cited
1979
Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA
THE mutagenic lesion O6-methylguanine (O6-MeG) is slowly but actively removed from DNA in Escherichia coli cells treated with… Expand
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Review
1977
Review
1977
Formation and metabolism of alkylated nucleosides: possible role in carcinogenesis by nitroso compounds and alkylating agents.
  • A. Pegg
  • Advances in cancer research
  • 1977
    • Corpus ID: 43066125
Publisher Summary Alkylation of nucleic acids occurs both physiologically within living cells and after the administration of… Expand
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Highly Cited
1966
Highly Cited
1966
Teratogenic and Carcinogenic Effects in the Offspring after Single Injection of Ethylnitrosourea to Pregnant Rats
ALKYLNITROSOUREAS give the corresponding alkylating diazoalkanes on heterolysis, and are potent carcinogens, selectively… Expand
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