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Aniline Mustard

Known as: Aniline Mustard [Chemical/Ingredient], .beta.,.beta.'-Dichlorodiethylaniline, N,N-bis(2-chloroethyl)benzenamine 
An alkylating mustard with antineoplastic activity. Aniline mustard forms covalent linkages with nucleophilic centers, resulting in depurination… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (1)

Antineoplastic Agents, Alkylating
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Narrower (4)

Lymphocingamma-glutamyl 4-phenylene diamine mustardhydroxyaniline mustardp-hydroxyaniline mustard glucuronide, tetra-n-butyl ammonium salt

Papers overview

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Highly Cited
1990
Highly Cited
1990
DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard.
A series of DNA-targeted aniline mustards have been prepared, and their chemical reactivity and in vitro and in vivo cytotoxicity… 
1986
1986
Organoselenium chemistry. Alkylation of acid, ester, amide, and ketone enolates with bromomethyl benzyl selenide and sulfide: preparation of selenocysteine derivatives
Obtention de benzylseleno-3-aces, esters et amides d'acides vinyliques, d'enones et selenocysteines et selenocystines protegees 
1984
1984
The effect of erythrocytes and hemoglobin on sister chromatid exchange induction in cultured human lymphocytes exposed to aniline HCI.
Erythrocytes [red blood cells (RBCs)] possess aniline hydroxylase activity. When aniline interacts with ferrohemoglobin in the… 
1982
1982
DNA damage in liver, kidney, bone marrow, and spleen of rats and mice treated with commercial and purified aniline as determined by alkaline elution assay and sister chromatid exchange induction.
Aniline of unknown purity has been reported to induce spleen hemangiosarcoma in rats. Aniline has been found to be negative in… 
1977
1977
Inhibition by cyanide of drug oxidations in rat liver microsomes.
Cyanide inhibited microsomal activities of aniline hydroxylation and aminopyrine, ethylmorphine and codeine demethylations and… 
1972
1972
Enhancement of aniline p-hydroxylation by acetone in rat liver microsomes.
1. Acetone (0.8 M) enhanced the p-hydroxylation of aniline about 3-4 fold when added to the incubation mixture. Only inhibition… 
1968
1968
Photochromism of salicylidene aniline.
Photochromic properties of two crystalline forms of salicylidene aniline have been investigated, emphasizing properties not… 
1967
1967
Histochemical studies of the formazan reaction. II. The conversion of periodate-reactive mucosubstances into diphenyl and phenyl-4'-diazo-3, 3'-dimethoxybiphenyl formazans and related derivatives.
SYNOPSIS Periodate-reactive mucosubstances have been converted into highly-coloured formazans (as predicted in a previous… 
Review
1945
Review
1945
DYE POISONING IN THE NURSERY: A REVIEW OF SEVENTEEN CASES
Instances of acute poisoning by aniline and its derivatives occur not infrequently. Many of the cases reported among industrial… 
1942
1942
The Inhibition of a Diphosphopyridine Nucleotide System by Split Products of Dimethylaminoazobenzene
VOLUME 2 JANUARY, 1942 NUMBER 1 ...... The Inhibition of a Diphosphopyridine Nucleotide System by Split Products of… 
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