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It is shown that in allylic hydroxyl ations (catalyzed by either model metalloporphyrins or cytochrome P450) rehydridization could occur to yield multiple products.
The many roles of cytochrome b5.
Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues.
Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.
Spectral studies of drug interaction with hepatic microsomal cytochrome.
- J. Schenkman, H. Remmer, R. Estabrook
- Biology, Environmental ScienceMolecular pharmacology
- 1 March 1967
Two types of spectral changes are described as resulting from substrate interaction with a hepatic microsomal cytochrome; the magnitude of these spectral changes is dependent on protein concentration…
Kinetic parameters of drug-metabolizing enzymes in Ca 2+ -sedimented microsomes from rat liver.
Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1.
- D. Choudhary, I. Jansson, I. Stoilov, M. Sarfarazi, J. Schenkman
- Biology, MedicineDrug metabolism and disposition: the biological…
- 1 August 2004
A comparison of the kinetics of this metabolism by mouse and human CYP1B1 orthologs revealed the mouse enzyme to have a more favorable metabolism of DMBA, with a catalytic efficiency ratio (CER) of 0.23.
Direct Electrochemistry of Myoglobin and Cytochrome P450cam in Alternate Layer-by-Layer Films with DNA and Other Polyions
Alternate layer-by-layer polyion adsorption onto gold electrodes coated with chemisorbed mercaptopropanesulfonic acid gave stable, electroactive multilayer films containing the proteins myoglobin and…
Effects of testosterone and growth hormone treatment on hepatic microsomal P450 expression in the diabetic rat.
The lack of effect of human growth hormone treatment in the diabetic male on levels of individual P450 forms indicates that in diabetes there may be a change in the ability of the male rat hepatocyte to respond to a somatic signal, possibly as a result of the changes in other hormone factors.