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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
- T. Shimada, H. Yamazaki, M. Mimura, Y. Inui, F. Guengerich
- Medicine, BiologyJournal of Pharmacology and Experimental…
- 1 July 1994
The results presented in this study provide useful information for the study of drug biotransformation in humans and for the basis of drug toxicities, carcinogenesis and teratogenesis.
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.
The selectivity of this enzyme in the activation of a variety of environmental carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002 or NM2009 tester strains was examined using the SOS response as an end point of DNA damage.
Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.
- H. Yamazaki, Mami Nakamura, T. Yokoi
- Biology, ChemistryProtein Expression and Purification
- 1 April 2002
P450/NPR membrane systems containing b5 are useful models for prediction of the rates for liver microsomal P450-dependent drug oxidations and may be different in some human CYP2 family enzymes, possibly due to a conformational role of b5.
Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1.
- T. Shimada, H. Yamazaki, M. Foroozesh, N. Hopkins, W. Alworth, F. Guengerich
- Chemistry, BiologyChemical Research in Toxicology
- 5 August 1998
Several polycyclic hydrocarbons and their oxidation products are very inhibitory with respect to human P450s 1A1, 1A2, and 1B1; (ii) of these inhibitors only some are mechanism-based inactivators; and (iii) some of the inhibitors are potentially useful for distinguishing between human P 450s 2A1 and 2B1.
Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes.
The results suggest that CYP2C19 plays important roles in the oxidation of progesterone and testosterone in human liver microsomes, although the physiological significance of these metabolic pathways remains unclear.
Activation and detoxication of aflatoxin B1.
Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes
- H. Yamazaki, Kiyoshi Inoue, M. Hashimoto, T. Shimada
- Biology, ChemistryArchives of Toxicology
- 1 March 1999
The view that CYP2A6 has major roles for nicotine C-oxidation at lower substrate concentration and both CYP 2A6 and 2B6 play roles at higher substrate concentrations in human liver microsomes is supported.
Identification of a novel polymorphic enhancer of the human CYP3A4 gene.
The results suggest that CLEM4 is a constitutive enhancer of the CYP3A4 gene in the liver and that -11,129_-11,128insTGT may at least partly contribute to the interindividual variability of CYP 3A4 expression.
Limited frequency of the CYP2C19*17 allele and its minor role in a Japanese population.
- K. Sugimoto, T. Uno, H. Yamazaki, T. Tateishi
- Medicine, BiologyBritish Journal of Clinical Pharmacology
- 1 March 2008
The low frequency of CYP2C19*17 and the absence of a subject homozygous for *17 indicates that CYP1C2C20*17 plays a minor role in the Japanese population.
Molecular Cloning of a Novel Human Collectin from Liver (CL-L1)*
- K. Ohtani, Yasuhiko Suzuki, N. Wakamiya
- Biology, ChemistryThe Journal of Biological Chemistry
- 7 May 1999
The cloning of a cDNA encoding human collectin from liver (CL-L1 (collectin liver 1) that has typical collectin structural characteristics, consisting of an N-terminal cysteine-rich domain, a collagen-likedomain, a neck domain, and a carbohydrate recognition domain is reported.