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Carbazilquinone

Known as: Carbazilquinone [Chemical/Ingredient], Carboquinone, 2,5-Cyclohexadiene-1,4-dione, 2-(2-((aminocarbonyl)oxy)-1-methoxyethyl)-3,6-bis(1-aziridinyl)-5-methyl- 
An aziridinylbenzoquinone-based alkylating agent with potential antineoplastic activity. The alkylating group in carboquone becomes activated upon… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (1)

Antineoplastic Agents, Alkylating

Narrower (3)

EsquinonMQF-OK protocolMQF-OK-UFT protocol
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1995
1995
The subrenal capsule assay in selecting chemotherapy for ovarian cancer: a prospective randomized trial.
In order to find out whether the response rate and survival in epithelial ovarian cancer can be improved by aid of sensitivity… 
1994
1994
Expression of glutathione s‐transferasepi and sensitivity of human gastric cancer cells to cisplatin
Background. The authors examined the correlation between the expression of glutathione S‐transferase‐pi (GSTπ) and the… 
Highly Cited
1993
Highly Cited
1993
Applications of neural networks in structure-activity relationships of a small number of molecules.
We investigated the applications of back propagation artificial neural networks (ANN) for a small dataset analysis in the field… 
Highly Cited
1987
Highly Cited
1987
Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma.
The chemosensitivities of 41 poorly differentiated gastric cancer tissues were compared with that of 16 well differentiated… 
1986
1986
Drug monitoring by a fully automated high-performance liquid chromatographic technique, involving direct injection of plasma.
Highly Cited
1984
Highly Cited
1984
Comparison of 6-thioguanine-resistant mutation and sister chromatid exchanges in Chinese hamster V79 cells with forty chemical and physical agents.
The induction of sister chromatid exchanges (SCE) and mutation at the hypoxanthine-guanine phosphoribosyl transferase locus and… 
1980
1980
Synergistic cell killing by antitumor agents and hyperthermia in cultured cells.
The effects of treatment with several antitumor agents in combination with hyperthermia (42 degrees and 43 degrees) on the cell… 
Highly Cited
1978
Highly Cited
1978
Mutagenicity of several classes of antitumor agents to Salmonella typhimurium TA98, TA100, and TA92.
The mutagenic activities of antitumor agents, including 5 antibiotics, 19 antimetabolites, 5 alkylating agents, 2 alkaloids, 1… 
Highly Cited
1977
Highly Cited
1977
Electron spin resonance study on the mode of generation of free radicals of daunomycin, adriamycin, and carboquone in NAD(P)H-microsome system.
The mode of generation of free radicals of daunomycin, adriamycin, and carboquone in the NADPH-rat liver microsome system was… 
Highly Cited
1975
Highly Cited
1975
Generation of free radicals of quinone group-containing anti-cancer chemicals in NADPH-microsome system as evidenced by initiation of sulfite oxidation.
The prerequisit of reduction for activation of Mitomycin-C and unstability of its reduced form suggested investigation of the… 
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