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Carbazilquinone

Known as: Carbazilquinone [Chemical/Ingredient], Carboquinone, 2,5-Cyclohexadiene-1,4-dione, 2-(2-((aminocarbonyl)oxy)-1-methoxyethyl)-3,6-bis(1-aziridinyl)-5-methyl- 
An aziridinylbenzoquinone-based alkylating agent with potential antineoplastic activity. The alkylating group in carboquone becomes activated upon… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (1)

Antineoplastic Agents, Alkylating

Narrower (3)

EsquinonMQF-OK protocolMQF-OK-UFT protocol
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1995
1995
The subrenal capsule assay in selecting chemotherapy for ovarian cancer: a prospective randomized trial.
In order to find out whether the response rate and survival in epithelial ovarian cancer can be improved by aid of sensitivity… 
1994
1994
Expression of glutathione s‐transferasepi and sensitivity of human gastric cancer cells to cisplatin
Background. The authors examined the correlation between the expression of glutathione S‐transferase‐pi (GSTπ) and the… 
1994
1994
Antitumor chemosensitivity differs between clinical sarcoma and adenocarcinoma tissues.
The chemosensitivity of 43 human sarcoma tissues, including 18 osteosarcomas, 16 leiomyosarcomas and 9 liposarcomas, was compared… 
1990
1990
Chemosensitivity correlation between the primary tumors and simultaneous metastatic lymph nodes of patients evaluated by DNA synthesis inhibition assay
The chemosensitivities of primary tumors (PT) and simultaneous metastatic lymph nodes (MN) to mitomycin C (MMC), 5‐fluorouracil… 
1989
1989
Tumor tissue is more sensitive to mitomycin C, carboquone, and aclacinomycin A than is adjacent normal tissue in vitro
In tissues obtained from patients undergoing gastrectomy or colectomy, sensitivity to mitomycin C (MMC), carboquone (CQ), and… 
Highly Cited
1987
Highly Cited
1987
Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma.
The chemosensitivities of 41 poorly differentiated gastric cancer tissues were compared with that of 16 well differentiated… 
1986
1986
Drug monitoring by a fully automated high-performance liquid chromatographic technique, involving direct injection of plasma.
Highly Cited
1984
Highly Cited
1984
Comparison of 6-thioguanine-resistant mutation and sister chromatid exchanges in Chinese hamster V79 cells with forty chemical and physical agents.
The induction of sister chromatid exchanges (SCE) and mutation at the hypoxanthine-guanine phosphoribosyl transferase locus and… 
1983
1983
Interactions of beta-lactam antibiotics and antineoplastic agents
The in vitro interactions of four beta-lactam antibiotics and five antineoplastic agents were examined with 100 clinically… 
Highly Cited
1975
Highly Cited
1975
Generation of free radicals of quinone group-containing anti-cancer chemicals in NADPH-microsome system as evidenced by initiation of sulfite oxidation.
The prerequisit of reduction for activation of Mitomycin-C and unstability of its reduced form suggested investigation of the… 
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