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Intercalating Agents

Known as: Intercalating Agent, Intercalating Ligands, Ligands, Intercalating 
Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore… 
National Institutes of Health

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1,10-phenanthroline9-amino-6-chloro-2-methoxyacridineAcriflavineAmsacrine
Mutagensaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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Review
1997
Review
1997
Molecular mechanisms in retrovirus DNA integration.
Highly Cited
1994
Highly Cited
1994
Fast photoinduced electron transfer through DNA intercalation.
We report evidence for fast photoinduced electron transfer mediated by the DNA helix that requires metal complexes that are avid… 
Highly Cited
1989
Highly Cited
1989
Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates.
An acridine derivative was covalently linked to the 5' end of a homopyrimidine oligonucleotide. Specific binding to a homopurine… 
Highly Cited
1989
Highly Cited
1989
A premelting conformational transition in poly(dA)-Poly(dT) coupled to daunomycin binding.
Circular dichroism and UV absorbance spectroscopy were used to monitor and characterize a premelting conformational transition of… 
Highly Cited
1989
Highly Cited
1989
Radiotoxicity of an 125I-labeled DNA intercalator in mammalian cells.
To explore the effect of the Auger electron emitter 125I attached to a DNA intercalator, we have synthesized 125I- and 127I… 
Highly Cited
1987
Highly Cited
1987
Topoisomerase II-mediated DNA breaks and cytotoxicity in relation to cell proliferation and the cell cycle in NIH 3T3 fibroblasts and L1210 leukemia cells.
The DNA intercalator, 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) and the nonintercalator, etoposide (VP-16) produce… 
Highly Cited
1986
Highly Cited
1986
Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors.
Most DNA intercalators and epipodophyllotoxins inhibit mammalian topoisomerase II by trapping the enzyme within DNA cleavage… 
Highly Cited
1982
Highly Cited
1982
Protein-associated deoxyribonucleic acid strand breaks produced in mouse leukemia L1210 cells by ellipticine and 2-methyl-9-hydroxyellipticinium.
Highly Cited
1981
Highly Cited
1981
Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino) methanesulfon-m-anisidide and adriamycin.
The DNA intercalating agents 4'-(9-acridinyl-amino) methanesulfon-m-anisidide (m-AMSA) and adriamycin were studied by using… 
Highly Cited
1979
Highly Cited
1979
Binding of platinum(II) intercalation reagents to deoxyribnonucleic acid. Dependence on base-pair composition, nature of the intercalator, and ionic strength.
The DNA binding of three platinum(II) intercalation reagents has been studied and found to depend upon base composition, the… 
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