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Amsacrine

Known as: Amsacrine [Chemical/Ingredient], meta-AMSA, 4'-(9-Acridinylamino)methanesulfon-meta-anisidide 
An aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may… 
National Institutes of Health

Related topics

Related topics

32 relations

Narrower (16)

3-azidoamsacrine4-(9-acridinylamino)aniline9-anilinoacridineAEP protocol
AMSA-OAP protocolAmsacrine LactateIn BloodNCIt Antineoplastic Agent Terminology

Broader (2)

Antineoplastic AgentsIntercalating Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1993
Highly Cited
1993
Topoisomerase II alpha co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity.
Topoisomerase II alpha (topo II alpha) is a key enzyme in DNA replication and a target for many anti-cancer drugs. High levels… 
Highly Cited
1991
Highly Cited
1991
Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus.
Saintopin is an antitumor antibiotic recently discovered in mechanistically oriented screening using purified calf thymus DNA… 
Highly Cited
1990
Highly Cited
1990
Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.
In order to elucidate the mechanism by which the intercalative antineoplastic drug 4'-(9-acridinylamino)methanesulfon-m-anisidide… 
Highly Cited
1986
Highly Cited
1986
Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II.
DNA intercalating agents such as 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) have previously been found to induce in… 
Highly Cited
1986
Highly Cited
1986
Retinol metabolism in LLC-PK1 Cells. Characterization of retinoic acid synthesis by an established mammalian cell line.
Highly Cited
1984
Highly Cited
1984
High-dose cytosine arabinoside and m-AMSA is effective therapy in relapsed acute nonlymphocytic leukemia.
High-dose cytosine arabinoside ( HDARAC ) and 4'-(9 acridinylamino) methane sulfon -m-anisidine (m-AMSA) was administered as… 
Highly Cited
1981
Highly Cited
1981
Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring.
In an investigation of the structure-activity relationships in the 4'-(9-acridinylamino)methanesulfonanilide (AMSA) tumor… 
Highly Cited
1980
Highly Cited
1980
4'-(9-Acridinylamino) methanesulfon-m-anisidide (AMSA): a new drug effective in the treatment of adult acute leukemia.
Sixty-two adults with previously treated acute leukemia were treated with 4'-(9-acridinylamino) methanesulfon-m-anisidide (AMSA… 
Highly Cited
1977
Highly Cited
1977
Chemotherapy of human colon cancer xenografts in athymic nude mice
The lack of effective chemotherapy in advanced colon cancer and difficulties in evaluating response in clinical trials indicate a… 
Highly Cited
1974
Highly Cited
1974
The experimental antitumour properties of three congeners of the acridylmethanesulphonanilide (AMSA) series.
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