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Amsacrine
Known as:
Amsacrine [Chemical/Ingredient]
, meta-AMSA
, 4'-(9-Acridinylamino)methanesulfon-meta-anisidide
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An aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may…
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National Institutes of Health
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Related topics
Related topics
32 relations
Narrower (16)
3-azidoamsacrine
4-(9-acridinylamino)aniline
9-anilinoacridine
AEP protocol
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AMSA-OAP protocol
Amsacrine Lactate
In Blood
NCIt Antineoplastic Agent Terminology
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Broader (2)
Antineoplastic Agents
Intercalating Agents
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1988
1988
Production of protein-associated DNA breaks by 10-[diethylaminopropylamino]-6-methyl-5H-pyrido[3',4':4,5]pyrrolo [2,3-g]isoquinoline in cultured L1210 cells and in isolated nuclei: comparison with…
V. Pierson
,
A. Pierré
,
Y. Pommier
,
P. Gros
Cancer Research
1988
Corpus ID: 40216731
10-[3-Diethylaminopropylamino]-6-methyl-5H-pyrido[3',4':4,5] pyrrolo[2,3-g]isoquinoline (PZE) is an ellipticine derivative…
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1987
1987
In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia.
B. Andersson
,
M. Beran
,
M. Bakic
,
L. Silberman
,
R. Newman
,
L. Zwelling
Cancer Research
1987
Corpus ID: 39964187
Benzisoquinolinedione (nafidimide; NSC 308847) is an investigational drug currently in phase I clinical testing. We have studied…
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1985
1985
Effect of difluoromethylornithine, an inhibitor of polyamine biosynthesis, on the topoisomerase II-mediated DNA scission produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide in L1210 murine…
L. Zwelling
,
D. Kerrigan
,
L. Marton
Cancer Research
1985
Corpus ID: 40855709
Treatment of mouse leukemia L1210 cells with the polyamine biosynthesis inhibitor alpha-difluoromethylornithine (DFMO) increased…
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Highly Cited
1984
Highly Cited
1984
Changes in deoxyribonucleic acid linking number due to treatment of mammalian cells with the intercalating agent 4'-(9-acridinylamino)methanesulfon-m-anisidide.
Y. Pommier
,
M. Mattern
,
R. Schwartz
,
L. Zwelling
,
K. Kohn
Biochemistry
1984
Corpus ID: 2687886
Treatment of mammalian cells with DNA intercalating agents produces protein-associated DNA strand breaks. These breaks have been…
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1984
1984
Metabolism of 4'-(9-acridinylamino)methanesulfon-m-anisidide by rat liver microsomes.
D. Shoemaker
,
R. Cysyk
,
P. Gormley
,
J. Desouza
,
L. Malspeis
Cancer Research
1984
Corpus ID: 24918908
4'-(9-Acridinylamino)methanesulfon-m-anisidide (m-AMSA) is metabolized by a hepatic microsomal enzyme system composed of rat…
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1983
1983
Potential antitumor agents. 38. 3-substituted 5-carboxamido derivatives of amsacrine.
W. Denny
,
G. Atwell
,
B. Baguley
Journal of Medicinal Chemistry
1983
Corpus ID: 32436448
The synthesis and biological evaluation of a series of 3-substituted 5-carboxamido derivatives of amsacrine (m-AMSA) are…
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1982
1982
Cardiac abnormalities after AMSA administration.
L. Steinherz
,
P. Steinherz
,
D. Mangiacasale
,
C. Tan
,
D. Miller
Cancer treatment reports
1982
Corpus ID: 620443
AMSA produced changes on echocardiograms of 18 of 27 patients. Seven patients developed clinical congestive heart failure. The…
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Highly Cited
1981
Highly Cited
1981
Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring.
B. Baguley
,
W. Denny
,
G. Atwell
,
B. F. Cain
Journal of Medicinal Chemistry
1981
Corpus ID: 11068673
In an investigation of the structure-activity relationships in the 4'-(9-acridinylamino)methanesulfonanilide (AMSA) tumor…
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1981
1981
Identification of conjugation and cleavage products in the thiolytic metabolism of the anticancer drug 4'-(9-acridinylamino)methanesulfon-m-anisidide.
M. Przybylski
,
R. Cysyk
,
D. Shoemaker
,
R. Adamson
Biomedical mass spectrometry
1981
Corpus ID: 20097335
Conjugation and cleavage products in the thiolytic metabolism of the anticancer drug 4'-(9-acridinylamino)methanesulfon-m…
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1980
1980
Phase I clinical and pharmacokinetic study of 4'-(9-acridinylamino)-methanesulfon-m-anisidide in children with cancer.
G. Rivera
,
W. Evans
,
G. Dahl
,
G. Yee
,
C. Pratt
Cancer Research
1980
Corpus ID: 7360541
Forty-one pediatric patients with advanced cancer (24 with acute leukemia and 17 with diverse solid tumors) received 74 courses…
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