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Amsacrine Lactate

Known as: Methanesulfon-m-anisidide, 4'-(9-acridinylamino)-, compd. with Lactic Acid, N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide compd. with Lactic Acid, m-AMSA lactate 
The lactate form of amsacrine, an aminoacridine analog and topoisomerase II inhibitor, with antineoplastic activity. Although the exact relationship… Expand
National Institutes of Health

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Amsacrine

Papers overview

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2016
2016
Hydrogen isotope exchange with highly active iridium(I) NHC/phosphine complexes: a comparative counterion study.
Herein, we present a range of substrates that undergo hydrogen isotope exchange with an iridium(I) N-heterocyclic carbene… Expand
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2013
2013
Biaryl Amides and Hydrazones as Therapeutics for Prion Disease in Transgenic Mice
The only small-molecule compound demonstrated to substantially extend survival in prion-infected mice is a biaryl hydrazone… Expand
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1997
1997
Irreversible and reversible topoisomerase II DNA cleavage stimulated by clerocidin: sequence specificity and structural drug determinants.
In contrast to other topoisomerase II poisons, the microbial terpenoid clerocidin was shown to stimulate irreversible… Expand
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1990
1990
Induction of mammalian DNA topoisomerase II dependent DNA cleavage by antitumor antibiotic streptonigrin.
Streptonigrin, a nonintercalative antitumor antibiotic, induced mammalian topoisomerase II dependent DNA cleavage in vitro. The… Expand
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1989
1989
Inhibition of protein synthesis reduces the cytotoxicity of 4'-(9-acridinylamino)methanesulfon-m-anisidide without affecting DNA breakage and DNA topoisomerase II in a murine mastocytoma cell line.
Stimulation of cleavable complex formation by 4'-(9-acridinylamino)methanesulfon-m-anisidide (mAMSA) and related anticancer drugs… Expand
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1988
1988
Topoisomerase II-mediated DNA damage produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines in L1210 cells and isolated nuclei: relation to cytotoxicity.
4'-(9-Acridinylamino)methanesulfon-m-anisidide (m-AMSA) is a DNA intercalating 9-aminoacridine with clinical activity in adult… Expand
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1985
1985
Effects of the DNA intercalators 4'-(9-acridinylamino)methanesulfon-m-anisidide and 2-methyl-9-hydroxyellipticinium on topoisomerase II mediated DNA strand cleavage and strand passage.
DNA topoisomerase II is believed to be the enzyme that produces the protein-associated DNA strand breaks observed in mammalian… Expand
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1984
1984
Identification of the breakage-reunion subunit of T4 DNA topoisomerase.
The antitumor drug 4'-(9-acridinylamino)methanesulfon-m-anisidide which stimulates the cleavable complex formation between… Expand
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1984
1984
Absence of swiveling at sites of intercalator-induced protein-associated deoxyribonucleic acid strand breaks in mammalian cell nucleoids.
The sedimentation of DNA-nuclear protein complexes in 1.9 M salt-neutral sucrose gradients (nucleoid sedimentation) was used to… Expand
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1979
1979
Phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in metastatic breast cancer.
A phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) was carried out in previously treated patients with… Expand
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