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Amsacrine Lactate

Known as: Methanesulfon-m-anisidide, 4'-(9-acridinylamino)-, compd. with Lactic Acid, N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide compd. with Lactic Acid, m-AMSA lactate 
The lactate form of amsacrine, an aminoacridine analog and topoisomerase II inhibitor, with antineoplastic activity. Although the exact relationship… 
National Institutes of Health

Papers overview

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2016
2016
Herein, we present a range of substrates that undergo hydrogen isotope exchange with an iridium(I) N-heterocyclic carbene… 
2013
2013
The only small-molecule compound demonstrated to substantially extend survival in prion-infected mice is a biaryl hydrazone… 
1997
1997
In contrast to other topoisomerase II poisons, the microbial terpenoid clerocidin was shown to stimulate irreversible… 
Highly Cited
1990
Highly Cited
1990
Streptonigrin, a nonintercalative antitumor antibiotic, induced mammalian topoisomerase II dependent DNA cleavage in vitro. The… 
Highly Cited
1988
Highly Cited
1988
4'-(9-Acridinylamino)methanesulfon-m-anisidide (m-AMSA) is a DNA intercalating 9-aminoacridine with clinical activity in adult… 
Highly Cited
1985
Highly Cited
1985
DNA topoisomerase II is believed to be the enzyme that produces the protein-associated DNA strand breaks observed in mammalian… 
Highly Cited
1984
Highly Cited
1984
Highly Cited
1984
Highly Cited
1984
The sedimentation of DNA-nuclear protein complexes in 1.9 M salt-neutral sucrose gradients (nucleoid sedimentation) was used to… 
1979
1979
A phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) was carried out in previously treated patients with…