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Amsacrine Lactate

Known as: Methanesulfon-m-anisidide, 4'-(9-acridinylamino)-, compd. with Lactic Acid, N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide compd. with Lactic Acid, m-AMSA lactate 
The lactate form of amsacrine, an aminoacridine analog and topoisomerase II inhibitor, with antineoplastic activity. Although the exact relationship… 
National Institutes of Health

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Amsacrine

Papers overview

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2010
2010
Synthèse de molécules d'intérêt biologique. Contribution à la synthèse des bastadines
Les metabolites constituent un domaine biochimique dont l'interet est en constante progression. En effet, ces molecules sont… 
1993
1993
Synthesis and antitumor activity of pyrido-amsacrine analogues and related compounds.
The pyrido derivatives of amsacrine [4'-(9-acridinylamino) methanesulfon-m-anisidine] were prepared and evaluated in the L1210… 
1991
1991
Topoisomerase II activity in the replicating DNA of irradiated hamster cells.
The activity of DNA topoisomerase II in the replicating DNA of irradiated Chinese hamster ovary cells was estimated by… 
Highly Cited
1990
Highly Cited
1990
Induction of mammalian DNA topoisomerase II dependent DNA cleavage by antitumor antibiotic streptonigrin.
Streptonigrin, a nonintercalative antitumor antibiotic, induced mammalian topoisomerase II dependent DNA cleavage in vitro. The… 
1985
1985
Chromosomol DNA fragments from mouse cells exposed to an intercalating agent contain a 175-kdalton terminal polypeptide.
  • R. RalphR. Hancock
  • Canadian journal of biochemistry and cell biology…
  • 1985
  • Corpus ID: 8939518
A 175 kdalton (kDa) polypeptide is bound covalently to the chromosomal DNA fragments from mouse cells exposed to the… 
1985
1985
Phase II study with amsacrines (m-AMSA and m-AMSA lactate) in refractory lymphomas.
A total of 70 patients with malignant lymphomas refractory to one or more chemotherapeutic regimens were treated with iv… 
Highly Cited
1984
Highly Cited
1984
Absence of swiveling at sites of intercalator-induced protein-associated deoxyribonucleic acid strand breaks in mammalian cell nucleoids.
The sedimentation of DNA-nuclear protein complexes in 1.9 M salt-neutral sucrose gradients (nucleoid sedimentation) was used to… 
1983
1983
Blocked 5'-termini in the fragments of chromosomal DNA produced in cells exposed to the antitumor drug 4'-[(9-acridinyl)-amino]methanesulphon-m-anisidide (mAMSA).
Comparison of the sensitivity of DNA isolated from untreated and mAMSA-treated PY815 mouse mastocytoma cells to hydrolysis by E… 
1981
1981
A phase II evaluation of m-AMSA, 4'-(9-acridinylamino) methanesulfon-m-anisidide, in patients with breast cancer.
A phase II study of m-AMSA, 4'-(9-acridinylamino) methanesulfon-m-anisidide was carried out in 40 patients with metastatic… 
1979
1979
Phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in metastatic breast cancer.
A phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) was carried out in previously treated patients with… 
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