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Amsacrine Lactate

Known as: Methanesulfon-m-anisidide, 4'-(9-acridinylamino)-, compd. with Lactic Acid, N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide compd. with Lactic Acid, m-AMSA lactate 
The lactate form of amsacrine, an aminoacridine analog and topoisomerase II inhibitor, with antineoplastic activity. Although the exact relationship… Expand
National Institutes of Health

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Amsacrine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Biaryl Amides and Hydrazones as Therapeutics for Prion Disease in Transgenic Mice
The only small-molecule compound demonstrated to substantially extend survival in prion-infected mice is a biaryl hydrazone… Expand
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1997
1997
Irreversible and reversible topoisomerase II DNA cleavage stimulated by clerocidin: sequence specificity and structural drug determinants.
In contrast to other topoisomerase II poisons, the microbial terpenoid clerocidin was shown to stimulate irreversible… Expand
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Highly Cited
1990
Highly Cited
1990
Induction of mammalian DNA topoisomerase II dependent DNA cleavage by antitumor antibiotic streptonigrin.
Streptonigrin, a nonintercalative antitumor antibiotic, induced mammalian topoisomerase II dependent DNA cleavage in vitro. The… Expand
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Highly Cited
1989
Highly Cited
1989
Inhibition of protein synthesis reduces the cytotoxicity of 4'-(9-acridinylamino)methanesulfon-m-anisidide without affecting DNA breakage and DNA topoisomerase II in a murine mastocytoma cell line.
Stimulation of cleavable complex formation by 4'-(9-acridinylamino)methanesulfon-m-anisidide (mAMSA) and related anticancer drugs… Expand
Highly Cited
1988
Highly Cited
1988
Topoisomerase II-mediated DNA damage produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines in L1210 cells and isolated nuclei: relation to cytotoxicity.
4'-(9-Acridinylamino)methanesulfon-m-anisidide (m-AMSA) is a DNA intercalating 9-aminoacridine with clinical activity in adult… Expand
Highly Cited
1985
Highly Cited
1985
Effects of the DNA intercalators 4'-(9-acridinylamino)methanesulfon-m-anisidide and 2-methyl-9-hydroxyellipticinium on topoisomerase II mediated DNA strand cleavage and strand passage.
DNA topoisomerase II is believed to be the enzyme that produces the protein-associated DNA strand breaks observed in mammalian… Expand
Highly Cited
1984
Highly Cited
1984
Identification of the breakage-reunion subunit of T4 DNA topoisomerase.
The antitumor drug 4'-(9-acridinylamino)methanesulfon-m-anisidide which stimulates the cleavable complex formation between… Expand
1984
1984
Absence of swiveling at sites of intercalator-induced protein-associated deoxyribonucleic acid strand breaks in mammalian cell nucleoids.
The sedimentation of DNA-nuclear protein complexes in 1.9 M salt-neutral sucrose gradients (nucleoid sedimentation) was used to… Expand
1983
1983
Blocked 5'-termini in the fragments of chromosomal DNA produced in cells exposed to the antitumor drug 4'-[(9-acridinyl)-amino]methanesulphon-m-anisidide (mAMSA).
Comparison of the sensitivity of DNA isolated from untreated and mAMSA-treated PY815 mouse mastocytoma cells to hydrolysis by E… Expand
1979
1979
Phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in metastatic breast cancer.
A phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) was carried out in previously treated patients with… Expand
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