Amsacrine Lactate

Known as: Methanesulfon-m-anisidide, 4'-(9-acridinylamino)-, compd. with Lactic Acid, N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide compd. with Lactic Acid, m-AMSA lactate 
The lactate form of amsacrine, an aminoacridine analog and topoisomerase II inhibitor, with antineoplastic activity. Although the exact relationship… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2013
01219792013

Papers overview

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2013
2013
The only small-molecule compound demonstrated to substantially extend survival in prion-infected mice is a biaryl hydrazone… (More)
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1988
1988
4'-(9-Acridinylamino)methanesulfon-m-anisidide (m-AMSA) is a DNA intercalating 9-aminoacridine with clinical activity in adult… (More)
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1988
1988
The mechanisms of resistance to doxorubicin (DX) were investigated using a human colon adenocarcinoma cell line (LoVo) and a… (More)
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1987
1987
The DNA cleavage produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) in mammalian cells is putatively mediated by… (More)
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1985
1985
DNA topoisomerase II is believed to be the enzyme that produces the protein-associated DNA strand breaks observed in mammalian… (More)
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1985
1985
A total of 70 patients with malignant lymphomas refractory to one or more chemotherapeutic regimens were treated with iv… (More)
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1984
1984
The antitumor drug 4'-(9-acridinylamino)methanesulfon-m-anisidide which stimulates the cleavable complex formation between… (More)
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1984
1984
4'-(9-Acridinylamino)methanesulfon-m-anisidide (mAMSA) interacts with Cu(II) ion, as indicated by changes in the mAMSA absorption… (More)
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1982
1982
Phase I clinical studies of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) using several dose schedules have shown… (More)
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1979
1979
A phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) was carried out in previously treated patients with… (More)
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