Signaling Pathways in Melanogenesis
- Stacey A. N. D’mello, G. Finlay, B. Baguley, M. Askarian-Amiri
- BiologyInternational Journal of Molecular Sciences
- 1 July 2016
The regulatory mechanisms involved in melanogenesis are discussed and how intrinsic and extrinsic factors regulate melanin production are explained, as well as the regulatory roles of different proteins involved in pigment molecules that are endogenously synthesized by melanocytes.
Disrupting tumour blood vessels
- G. Tozer, C. Kanthou, B. Baguley
- Biology, MedicineNature Reviews. Cancer
- 1 June 2005
A full understanding of the action of tubulin-binding combretastatins and other VDAs will provide insights into mechanisms that control tumour blood flow and will be the basis for the development of new therapeutic drugs for targeting the established tumour vasculature for therapy.
Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.
- C. Burd, Wenjin Liu, N. Sharpless
- BiologyCancer Discovery
- 1 December 2014
This work identifies a faithful model of human NRAS-mutant melanoma, and suggests that the increased melanomagenecity of NrasQ61R over NrasG12D is due to heightened abundance of the active, GTP-bound form rather than differences in the engagement of downstream effector pathways.
Multiple Drug Resistance Mechanisms in Cancer
- B. Baguley
- Biology, MedicineMolecular Biotechnology
- 18 August 2010
The complexity of mechanisms contributing to multiple drug resistance demands a broad strategy for the development of methods to overcome MDR in a clinical setting.
A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types
- S. Jamieson, J. Flanagan, P. Shepherd
- BiologyBiochemical Journal
- 14 June 2011
Results show that inhibition of p110α alone has the potential to block growth factor signalling and reduce growth in a subset of tumours.
Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs
- D. Screnci, M. McKeage, P. Galettis, T. Hambley, B. Palmer, B. Baguley
- Biology, ChemistryBritish Journal of Cancer
- 1 February 2000
The hydrophobicity of platinum drugs correlates with platinum sequestration in the peripheral nervous system but not with neurotoxicity, and differences in the reactivity of platinum complexes accounts for some of the variation in their neurotoxicity.
Early stages of the apoptotic pathway in plant cells are reversible
- I. O'brien, B. Baguley, B. Murray, B. Morris, I. Ferguson
- Biology
- 1 March 1998
Epigenetic regulation in human melanoma: past and future
- Debina Sarkar, E. Leung, B. Baguley, G. Finlay, M. Askarian-Amiri
- BiologyEpigenetics
- 14 January 2015
This work focuses on how epigenetic events intertwine with signaling pathways and contribute to the molecular pathogenesis of melanoma.
Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice
- L. Ching, S. Zwain, B. Baguley
- Biology, MedicineBritish Journal of Cancer
- 17 February 2004
Results suggest that blood flow inhibition caused by DMXAA is tumour tissue-specific and is a consequence of induction of apoptosis in tumour vascular endothelial cells.
Papulacandin B: an inhibitor of glucan synthesis in yeast spheroplasts.
- B. Baguley, G. Römmele, J. Gruner, W. Wehrli
- BiologyEuropean Journal of Biochemistry
- 1 July 1979
It is concluded that papulacandin B and probably also echinocand in B inhibit glucan synthesis during cell-wall synthesis, and thus cause lysis of cells by osmotic rupture.
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