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Secondary brain tumors in children treated for acute lymphoblastic leukemia at St Jude Children's Research Hospital.
PURPOSE To evaluate the incidence of and potential risk factors for second malignant neoplasms of the brain following treatment for childhood acute lymphoblastic leukemia (ALL). PATIENTS ANDExpand
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High‐dose methotrexate‐induced nephrotoxicity in patients with osteosarcoma
High‐dose methotrexate (HDMTX)‐induced renal dysfunction can be life threatening, because it delays methotrexate (MTX) excretion, thereby exacerbating the other toxicities of MTX. HDMTX‐inducedExpand
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The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity.
We conducted a randomized controlled trial to determine whether intensive multi-agent adjuvant chemotherapy improves the chances of relapse-free survival in patients with nonmetastatic high-gradeExpand
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Colorectal carcinoma in childhood and adolescence: a clinicopathologic review.
PURPOSE Pediatric colorectal carcinoma (CRC) is rare, but the available data suggest that it is more likely than adult CRC to be advanced at presentation and to have a poor outcome. We sought toExpand
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Direct translation of a protracted irinotecan schedule from a xenograft model to a phase I trial in children.
PURPOSE In a preclinical model of neuroblastoma, administration of irinotecan daily 5 days per week for 2 consecutive weeks ([qd x 5] x 2) resulted in greater antitumor activity than did a singleExpand
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Hemangiopericytoma in children and infants
Hemangiopericytoma (HPC) is a soft‐tissue neoplasm most commonly seen in adults; only 5–10% of cases occur in children. Childhood HPC comprises two distinct clinical entities. In children older thanExpand
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Colon carcinoma in children and adolescents. A review of 30 cases
Carcinoma of the large bowel is rare in persons under the age of 30, and generally presents with advanced stages of disease. From 1964 to 1984, 30 patients presented with nonfamilial large bowelExpand
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Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma
The purpose of this article was to evaluate the utility of a pharmacokinetically modeled measure of regional contrast access, based on dynamic contrast‐enhanced magnetic resonance imaging (MRI)Expand
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Second malignancies after Ewing's sarcoma: radiation dose-dependency of secondary sarcomas.
BACKGROUND An excess risk of second malignancies has been reported in survivors of Ewing's sarcoma. We examined a multiinstitutional data base to reevaluate the risk among survivors of Ewing'sExpand
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Saturable pharmacokinetics and paclitaxel pharmacodynamics in children with solid tumors.
PURPOSE Our aim was to evaluate the pharmacokinetics and pharmacodynamics of paclitaxel (Taxol; Bristol-Myers Squibb Co, Princeton, NJ) in children, and to determine whether paclitaxel exhibitedExpand
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