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Bioavailability of curcumin: problems and promises.
TLDR
Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
TLDR
Chronic behavioral stress results in higher levels of tissue catecholamines, greater tumor burden and more invasive growth of ovarian carcinoma cells in an orthotopic mouse model, and β-adrenergic activation of the cAMP–PKA signaling pathway is identified as a major mechanism by which behavioral stress can enhance tumor angiogenesis in vivo and thereby promote malignant cell growth.
Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer
TLDR
Oral curcumin is well tolerated and, despite its limited absorption, has biological activity in some patients with pancreatic cancer.
Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-κB Pathway in Breast Cancer Cells and Inhibits Lung Metastasis of Human Breast Cancer in Nude Mice
TLDR
Dietary administration of curcumin significantly decreased the incidence of breast cancer metastasis to the lung and suppressed the expression of NF-κB, cyclooxygenase 2, and matrix metalloproteinase-9 in a human breast cancer xenograft model.
Cardiac glycosides as novel cancer therapeutic agents.
TLDR
This review focuses on recent findings on cellular pharmacology of cardiac glycosides as they relate to treatment of human cancer and attempts to explain why these agents have been overlooked in the past.
Phase I trial of oral green tea extract in adult patients with solid tumors.
TLDR
Oral GTE at the doses studied can be taken safely for at least 6 months, and a dose of 1.0 g/m(2) tid (equivalent to 7 to 8 Japanese cups [120 mL] of green tea three times daily) is recommended for future studies.
Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells.
TLDR
Exposure of lung cancer cells to EPA results in a decrease in the COX-2-mediated formation of PGE(2), an increase in the level of P GE(3), and PGE (3)-mediated inhibition of tumor cell proliferation.
Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall‐cell lung cancer, or pancreatic cancer
TLDR
A pilot study of huachansu, a Chinese medicine that comes from dried toad venom from the skin glands of Bufo gargarizans or B. melanostictus, in patients with advanced cancer found it helpful in the treatment of various cancers.
Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.
TLDR
Results indicate that oleandrin inhibits activation of NF-kappaB and AP-1 and their associated kinases, which may provide a molecular basis for the ability of ole andrin to suppress inflammation and perhaps tumorigenesis.
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