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Reaction of geldanamycin and C17-substituted analogues with glutathione: product identifications and pharmacological implications.
TLDR
The reaction occurs at pH 7.0, 37 degrees C, and a physiological concentration of GSH, indicating that cellular GSH could play a role in modulating the cellular toxicity of these agents and therefore be a factor in their mechanism of differential toxicity. Expand
Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid.
TLDR
Variants of the Lewis lung carcinoma selected for resistance to N-(phosphonacetyl)-L-aspartic acid (PALA) by treatment of tumor-bearing mice with repetitive subcurative doses of PALA may serve to competitively displace PALA from ATCase, diminish enzyme inhibition, and allow pyrimidine biosynthesis to proceed despite therapy. Expand
Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors.
TLDR
Studies on the metabolism of zebularine in liver cytosol from humans and other mammals found that the Michaelis-Menten kinetics of aldehyde oxidase and its inhibition by raloxifene and BAU were highly variable between species. Expand
Kinetics of cis‐dichlorodiammineplatinum
TLDR
The cancer chemotherapeutic cis‐dichlorodiammineplatinum (cis‐DDP) was administered to 8 patients and the non‐protein‐bound platinum was found to be rapidly and biphasically cleared from the plasma with half‐life values of 8 to 10 min and 40 to 45 min. Expand
Effect of inhibitors of the de novo pyrimidine biosynthetic pathway on serum uridine levels in mice.
TLDR
Three inhibitors of the de novo pyrimidine biosynthetic pathway were studied to determine their effects on circulating uridine concentration in BDF1 mice and reduced serum uridine levels by 55% could contribute to the antitumor effectiveness of N-(phosphonacetyl)-L-aspartate by limiting the rescue of cells possessing a salvage pathway. Expand
Synthesis and release of hyaluronic acid by Swiss 3T3 fibroblasts.
TLDR
A model is proposed where each synthetase makes only one HA chain; after synthesis of a complete HA chain, HA synthet enzyme activity is terminated as its HA chain is released from the cell. Expand
Interaction of 4'-(9-acridinylamino)methanesulfon-m-anisidide with DNA and inhibition of oncornavirus reverse transcriptase and cellular nucleic acid polymerases.
TLDR
The relatively high concentrations of AMSA required for inhibition of nucleic acid-polymerizing enzyme activities as compared to the concentrations necessary for cytotoxicity in vitro suggest that the interaction with DNA alone might not fully explain its antitumor activity. Expand
Enhancement of bleomycin activity against Lewis lung tumors in mice by local hyperthermia.
TLDR
This report demonstrates in vivo a more than additive interaction between local tumor hyperthermia and bleomycin against s.c-implanted Lewis lung carcinomas in mice. Expand
Antitumor activity and biochemical effects of aphidicolin glycinate (NSC 303812) alone and in combination with cisplatin in vivo.
TLDR
The rapid recovery of DNA synthesis inhibition supports the use of prolonged infusion schedules in clinical trials, but the lack of evidence of selectivity for tumor cells suggests that AG may be of limited therapeutic value as a single agent. Expand
Isolation and characterization by electrospray-ionization mass spectrometry and high-performance anion-exchange chromatography of oligosaccharides derived from hyaluronic acid by hyaluronate lyase
TLDR
This study demonstrates the usefulness of ESIMS and HPAEC-PAD in the analysis and characterization of anionic glycosaminoglycan-type oligosaccharides. Expand
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