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How Do We Define Cure of Diabetes?
A consensus group of experts comprised of experts in pediatric and adult endocrinology, diabetes education, transplantation, metabolism, bariatric/metabolic surgery, and (for another perspective) hematology-oncology met in June 2009 to discuss issues. Expand
Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
- K. Stenloef, W. Cefalu, +5 authors G. Meininger
- Diabetes, obesity & metabolism
- 24 January 2013
The efficacy and safety of canagliflozin were evaluated in subjects with T2DM inadequately controlled with diet and exercise. Expand
Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3…
Findings support the use of canagliflozin as a viable treatment option for patients who do not achieve sufficient glycaemic control with metformin therapy, and provide greater HbA1c reduction than does glimepiride, and is well tolerated in patients with type 2 diabetes receiving meetformin. Expand
Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice
Dietary supplementation of butyrate can prevent and treat diet-induced insulin resistance in mouse and the mechanism ofbutyrate action is related to promotion of energy expenditure and induction of mitochondria function. Expand
Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range
This article summarizes the ATTD consensus recommendations for relevant aspects of CGM data utilization and reporting among the various diabetes populations. Expand
Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women.
- A. Stull, Katherine C. Cash, W. Johnson, C. Champagne, W. Cefalu
- The Journal of nutrition
- 1 October 2010
In conclusion, daily dietary supplementation with bioactives from whole blueberries improved insulin sensitivity in obese, nondiabetic, and insulin-resistant participants. Expand
Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes.
- Elizabeth F Sutton, R. Beyl, K. Early, W. Cefalu, E. Ravussin, C. Peterson
- Cell metabolism
- 5 June 2018
It is demonstrated for the first time in humans that eTRF improves some aspects of cardiometabolic health and that IF's effects are not solely due to weight loss. Expand
Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels
When consuming stevia and aspartame preloads, participants did not compensate by eating more at either their lunch or dinner meal and reported similar levels of satiety compared to when they consumed the higher calorie sucrose preload. Expand
Adipocyte iron regulates adiponectin and insulin sensitivity.
- J. Gabrielsen, Yan Gao, +10 authors D. McClain
- Biology, Medicine
- The Journal of clinical investigation
- 1 October 2012
A causal role for iron as a risk factor for metabolic syndrome and a role for adipocytes in modulating metabolism through adiponectin in response to iron stores are demonstrated. Expand
Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes
As adjunct to insulin, dual S GLT1 and SGLT2 inhibition with sotagliflozin improved glycemic control and the CGM profile with bolus insulin dose reduction, weight loss, and no increased hypoglycemia in type 1 diabetes. Expand