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Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice.
Forty-one food additives and 20 chemotherapeutic agents were examined for their ability to induce primary lung tumors in A mice and 12 were found to be positive in inducing pulmonary tumors.
Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.
It is suggested that agents that modify CYP2E1 activity at the tumor initiation stage might either enhance or inhibit colon carcinogenesis, depending on whether AOM or MAMAc is used as the carcinogen.
Tea and health: a historical perspective.
Carcinogenicity tests of certain environmental and industrial chemicals.
Fourteen chemicals of varied uses were tested for carcinogenicity by oral administration in male and female Charles River CD rats, and propane sultone, propylene imine, and ethylenethiourea were carcinogenic, in addition to the positive control N-2-fluorenylacetamide.
Colon carcinogens: Their metabolism and mode of action
On the basis of these models, colon cancer formation in man may involve ingestion of complex carcinogens with diet, with liberation of the active agent by bacterial enzymes, ingestion of procarcinogens, absorption, metabolism by liver, secretion in bile, and freeing of active agent in gut.
Testing of twenty-one environmental aromatic amines or derivatives for long-term toxicity or carcinogenicity.
Twenty-one aromatic amines or derivatives were tested for long-term toxicity by dietary administration to male Charles River rats and male and female HaM/lCR mice, and four inactive compounds included m-phenyl-enediamine, 2,4-dinitrochlorobenzene, benzoguanamine, and dicyclopentadiene dioxide.
Effects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 rat.
Beverages widely used by man altered host biochemistry as regards specific phase I and II enzymes in liver of rat and specific serum parameters were studied.
Effect of dietary undegraded carrageenan on colon carcinogenesis in F344 rats treated with azoxymethane or methylnitrosourea.
The undegraded carrageenan (Viscarin 402) in the diet had an enhancing effect in colorectal carcinogenesis in rats evoked by AOM or MNU.
Chemopreventive Effects of Cocoa Polyphenols on Chronic Diseases 1
  • J. Weisburger
  • Biology, Medicine
    Experimental biology and medicine
  • 1 October 2001
It would seem reasonable to suggest inhibition of the several phases of the complex processes leading to cancer, as a function of quantitative intake of antioxidants, including those from cocoa and chocolates.