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Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair
Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.
It is reported that Spc1 also has an important role in regulating sexual development in S. pombe and is required for induction of meiotic genes and stress-response genes, such as gpd1+ and pyp2+, that are transcriptionally regulated by Spc 1.
Mus81-Eme1 Are Essential Components of a Holliday Junction Resolvase
Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast
It is reported here that a fission yeast MAP kinase pathway links the cell-cycle G2/M control with changes in the extracellular environment that affect cell physiology.
Negative regulation of mitosis by wee1 +, a gene encoding a protein kinase homolog
Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases
ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1
- Zhongsheng You, C. Chahwan, J. Bailis, T. Hunter, P. Russell
- BiologyMolecular and Cellular Biology
- 1 July 2005
It is proposed that conformational changes in the MRN complex that occur upon binding to damaged DNA are transmitted through the FXF/Y-HEAT interface to activate ATM, and this interaction also retains active ATM at sites of DNA damage.
Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.
Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
Rad24 appears to function as an attachable nuclear-export signal that enhances the nuclear export of Cdc25 in response to DNA damage.