P. Russell

Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast.

In fission yeast the onset of mitosis is brought about by Cdc2/Cdc13 kinase, which is inhibited by the Wee1/Mik1 tyrosine kinases and activated by Cdc25 tyrosine phosphatase. This control network… (More)

Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog.

P. Russell, P. Nurse
Cell
1987

Fission yeast wee1- mutants initiate mitosis at half the cell size of wild type. The wee1+ activity is required to prevent lethal premature mitosis in cells that overproduce the mitotic inducer… (More)

Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.

Kazumasa Shiozaki, P. Russell
Genes & development
1996

The stress-activated Wis1-Spc1 protein kinase cascade links mitotic control with environmental signals in Schizosaccharomyces pombe. Fission yeast spc1- mutants are delayed in G2 during normal growth… (More)

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein.

Antonia Lopez-Girona, B A Furnari, Odile Mondésert, P. Russell
Nature
1999

DNA damage activates a cell-cycle checkpoint that prevents mitosis while DNA repair is under way. The protein Chk1 enforces this checkpoint by phosphorylating the mitotic inducer Cdc25.… (More)

Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.

Arrest of the cell cycle at the G2 checkpoint, induced by DNA damage, requires inhibitory phosphorylation of the kinase Cdc2 in both fission yeast and human cells. The kinase Wee1 and the phosphatase… (More)

Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe.

Geneviève Degols, Kazumasa Shiozaki, P. Russell
Molecular and cellular biology
1996

Spc1, an osmotic-stress-stimulated mitogen-activated protein kinase (MAPK) homolog in the fission yeast Schizosaccharomyces pombe, is required for the induction of mitosis and survival in… (More)

Replication checkpoint enforced by kinases Cds1 and Chk1.

M N Boddy, B A Furnari, Odile Mondésert, P. Russell
Science
1998

Cdc2, the kinase that induces mitosis, is regulated by checkpoints that couple mitosis to the completion of DNA replication and repair. The repair checkpoint kinase Chk1 regulates Cdc25, a… (More)

Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene.

Simon A. Gayther, Judy R. Mangion, +5 authors Douglas F. Easton
Nature genetics
1997

The breast cancer susceptibility gene BRCA2 on chromosome 13q12-13 has recently been identified. Germline mutations of BRCA2 are predicted to account for approximately 35% of families with multiple… (More)

cdc25+ functions as an inducer in the mitotic control of fission yeast.

P. Russell, P. Nurse
Cell
1986

In the fission yeast S. pombe the cdc25+ gene function is required to initiate mitosis. We have cloned the cdc25+ gene and have found that increased cdc25+ expression causes mitosis to initiate at a… (More)

Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1.

M N Boddy, Antonia Lopez-Girona, P. D. Shanahan, Heidrun Interthal, Wolfgang Heyer, P. Russell
Molecular and cellular biology
2000

Cds1, a serine/threonine kinase, enforces the S-M checkpoint in the fission yeast Schizosaccharomyces pombe. Cds1 is required for survival of replicational stress caused by agents that stall… (More)

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