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razoxane

Known as: 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+-)-, Razoxane [Chemical/Ingredient] 
An orally bioavailable bis-dioxopiperazine and a derivative of the chelating agent ethylenediaminetetraacetic acid (EDTA) with antineoplastic… Expand
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
Measurement of tumour and normal tissue perfusion in vivo in cancer patients will aid the clinical development of antiangiogenic… Expand
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Highly Cited
2001
Highly Cited
2001
Antiangiogenesis drugs can be difficult to evaluate because they produce disease stabilization rather than tumor regression… Expand
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Highly Cited
1998
Highly Cited
1998
Acute promyelocytic leukemia following mitoxantrone as single agent for the treatment of multiple sclerosis 
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1996
1996
PURPOSE The effect of the sensitizer razoxane on soft tissue sarcomas (STS) was prospectively evaluated in a randomized… Expand
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Highly Cited
1994
Highly Cited
1994
Certain bis(2,6-dioxopiperazine) derivatives, which include ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl]propane; ADR-529) and… Expand
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Review
1991
Review
1991
Razoxane blocks cell division in the G2/M phase of the cell generation cycle and appears to normalize tumour neovasculature… Expand
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1986
1986
Razoxane is one of the few agents which has shown activity in the treatment of advanced colorectal cancer. The drug has therefore… Expand
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Highly Cited
1986
Highly Cited
1986
Rapidly growing normal human neonatal prokeratinocytes (HPK) cultured in serum-free medium can be induced to undergo either… Expand
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1982
1982
: In this multi-institutional study of advanced gastric cancer, 73 patients were evaluable for response or survival. Patients… Expand
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Highly Cited
1980
Highly Cited
1980
This paper describes our experience with the use of razoxane (ICRF 159), a new anti‐mitotic drug, in the treatment of thirty‐six… Expand
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