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razoxane

Known as: 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+-)-, Razoxane [Chemical/Ingredient] 
An orally bioavailable bis-dioxopiperazine and a derivative of the chelating agent ethylenediaminetetraacetic acid (EDTA) with antineoplastic… Expand
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (10)

ADR 559AT 2153Dexrazoxane hydrochlorideFMI protocol
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Broader (1)

Antimitotic Agents
DexrazoxaneIn Bloodagonistsanalogs & derivatives
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Measurement of renal tumour and normal tissue perfusion using positron emission tomography in a phase II clinical trial of razoxane
Measurement of tumour and normal tissue perfusion in vivo in cancer patients will aid the clinical development of antiangiogenic… Expand
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Highly Cited
2001
Highly Cited
2001
Soluble Tie2 and Flt1 extracellular domains in serum of patients with renal cancer and response to antiangiogenic therapy.
Antiangiogenesis drugs can be difficult to evaluate because they produce disease stabilization rather than tumor regression… Expand
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Highly Cited
1998
Highly Cited
1998
Acute promyelocytic leukemia following mitoxantrone as single agent for the treatment of multiple sclerosis
Acute promyelocytic leukemia following mitoxantrone as single agent for the treatment of multiple sclerosis 
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1996
1996
Radiotherapy vs. radiotherapy and razoxane in the treatment of soft tissue sarcomas: final results of a randomized study.
PURPOSE The effect of the sensitizer razoxane on soft tissue sarcomas (STS) was prospectively evaluated in a randomized… Expand
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Highly Cited
1994
Highly Cited
1994
Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and…
Certain bis(2,6-dioxopiperazine) derivatives, which include ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl]propane; ADR-529) and… Expand
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Review
1991
Review
1991
Radiotherapeutic enhancement by razoxane.
Razoxane blocks cell division in the G2/M phase of the cell generation cycle and appears to normalize tumour neovasculature… Expand
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1986
1986
Randomized trial of oral adjuvant razoxane (ICRF 159) in resectable colorectal cancer: Five‐year follow‐up
Razoxane is one of the few agents which has shown activity in the treatment of advanced colorectal cancer. The drug has therefore… Expand
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Highly Cited
1986
Highly Cited
1986
Two functionally distinct classes of growth arrest states in human prokeratinocytes that regulate clonogenic potential.
Rapidly growing normal human neonatal prokeratinocytes (HPK) cultured in serum-free medium can be induced to undergo either… Expand
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1982
1982
Studies of Baker's antifol, methotrexate, and razoxane in advanced gastric cancer: A Gastrointestinal Tumor Study Group Report.
: In this multi-institutional study of advanced gastric cancer, 73 patients were evaluable for response or survival. Patients… Expand
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Highly Cited
1980
Highly Cited
1980
Razoxane (ICRF 159) in the treatment of psoriasis
This paper describes our experience with the use of razoxane (ICRF 159), a new anti‐mitotic drug, in the treatment of thirty‐six… Expand
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