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razoxane
Known as:
2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+-)-
, Razoxane [Chemical/Ingredient]
An orally bioavailable bis-dioxopiperazine and a derivative of the chelating agent ethylenediaminetetraacetic acid (EDTA) with antineoplastic…
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National Institutes of Health
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Related topics
Related topics
20 relations
Narrower (10)
ADR 559
AT 2153
Dexrazoxane hydrochloride
FMI protocol
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Broader (1)
Antimitotic Agents
Dexrazoxane
In Blood
agonists
analogs & derivatives
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Combined radiotherapy and razoxane in the treatment of chondrosarcomas and chordomas.
W. Rhomberg
,
H. Eiter
,
F. Böhler
,
S. Dertinger
Anticancer Research
2006
Corpus ID: 36487377
BACKGROUND Chondrosarcomas and chordomas are reported to have low radio-sensitivity. Therefore, a study was undertaken to explore…
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Highly Cited
2003
Highly Cited
2003
Measurement of renal tumour and normal tissue perfusion using positron emission tomography in a phase II clinical trial of razoxane
H. Anderson
,
J. Yap
,
+4 authors
A. Harris
British Journal of Cancer
2003
Corpus ID: 14964241
Measurement of tumour and normal tissue perfusion in vivo in cancer patients will aid the clinical development of antiangiogenic…
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Highly Cited
2000
Highly Cited
2000
A phase II study of razoxane, an antiangiogenic topoisomerase II inhibitor, in renal cell cancer with assessment of potential surrogate markers of angiogenesis.
J. Braybrooke
,
K. O'Byrne
,
+12 authors
A. Harris
Clinical Cancer Research
2000
Corpus ID: 430598
Renal cell carcinoma (RCC) is an angiogenic tumor resistant to standard cytotoxic chemotherapeutic agents. Although often…
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Highly Cited
1998
Highly Cited
1998
Acute promyelocytic leukemia following mitoxantrone as single agent for the treatment of multiple sclerosis
A. Vicari
,
F. Ciceri
,
+4 authors
L. Camba
Leukemia
1998
Corpus ID: 28315298
Acute promyelocytic leukemia following mitoxantrone as single agent for the treatment of multiple sclerosis
Highly Cited
1995
Highly Cited
1995
A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane).
B. Hasinoff
,
T. Kuschak
,
J. Yalowich
,
A. Creighton
Biochemical Pharmacology
1995
Corpus ID: 10562845
Highly Cited
1994
Highly Cited
1994
Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and…
G. Gorbsky
Cancer Research
1994
Corpus ID: 6486967
Certain bis(2,6-dioxopiperazine) derivatives, which include ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl]propane; ADR-529) and…
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1986
1986
Randomized trial of oral adjuvant razoxane (ICRF 159) in resectable colorectal cancer: Five‐year follow‐up
J. Gilbert
,
K. Hellmann
,
+5 authors
C. Wastell
British Journal of Surgery
1986
Corpus ID: 42758493
Razoxane is one of the few agents which has shown activity in the treatment of advanced colorectal cancer. The drug has therefore…
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Review
1983
Review
1983
Doxorubicin (adriamycin) cardiomyopathy.
E. Saltiel
,
W. Mcguire
Western Journal of Medicine
1983
Corpus ID: 20732121
Despite its vast utility in clinical oncology, the use of doxorubicin hydrochloride (Adriamycin) is limited by a potentially…
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1982
1982
Studies of Baker's antifol, methotrexate, and razoxane in advanced gastric cancer: A Gastrointestinal Tumor Study Group Report.
Bruckner Hw
,
Lokich Jj
,
Stablein Dm
1982
Corpus ID: 77688242
: In this multi-institutional study of advanced gastric cancer, 73 patients were evaluable for response or survival. Patients…
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1981
1981
Reduction of daunomycin toxicity by razoxane.
G. Wang
,
M. Finch
,
D. Trevan
,
K. Hellmann
British Journal of Cancer
1981
Corpus ID: 5316230
A single dose of 200 mg/kg razoxane protected mice against the subchronic lethal effects (i.e. within 21 days) of 10 mg/kg…
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