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razoxane

Known as: 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+-)-, Razoxane [Chemical/Ingredient] 
An orally bioavailable bis-dioxopiperazine and a derivative of the chelating agent ethylenediaminetetraacetic acid (EDTA) with antineoplastic… 
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (10)

ADR 559AT 2153Dexrazoxane hydrochlorideFMI protocol

Broader (1)

Antimitotic Agents
DexrazoxaneIn Bloodagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Combined radiotherapy and razoxane in the treatment of chondrosarcomas and chordomas.
BACKGROUND Chondrosarcomas and chordomas are reported to have low radio-sensitivity. Therefore, a study was undertaken to explore… 
Highly Cited
2003
Highly Cited
2003
Measurement of renal tumour and normal tissue perfusion using positron emission tomography in a phase II clinical trial of razoxane
Measurement of tumour and normal tissue perfusion in vivo in cancer patients will aid the clinical development of antiangiogenic… 
Highly Cited
2000
Highly Cited
2000
A phase II study of razoxane, an antiangiogenic topoisomerase II inhibitor, in renal cell cancer with assessment of potential surrogate markers of angiogenesis.
Renal cell carcinoma (RCC) is an angiogenic tumor resistant to standard cytotoxic chemotherapeutic agents. Although often… 
Highly Cited
1998
Highly Cited
1998
Acute promyelocytic leukemia following mitoxantrone as single agent for the treatment of multiple sclerosis
Acute promyelocytic leukemia following mitoxantrone as single agent for the treatment of multiple sclerosis 
Highly Cited
1995
Highly Cited
1995
A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane).
Highly Cited
1994
Highly Cited
1994
Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and…
Certain bis(2,6-dioxopiperazine) derivatives, which include ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl]propane; ADR-529) and… 
1986
1986
Randomized trial of oral adjuvant razoxane (ICRF 159) in resectable colorectal cancer: Five‐year follow‐up
Razoxane is one of the few agents which has shown activity in the treatment of advanced colorectal cancer. The drug has therefore… 
Review
1983
Review
1983
Doxorubicin (adriamycin) cardiomyopathy.
Despite its vast utility in clinical oncology, the use of doxorubicin hydrochloride (Adriamycin) is limited by a potentially… 
1982
1982
Studies of Baker's antifol, methotrexate, and razoxane in advanced gastric cancer: A Gastrointestinal Tumor Study Group Report.
: In this multi-institutional study of advanced gastric cancer, 73 patients were evaluable for response or survival. Patients… 
1981
1981
Reduction of daunomycin toxicity by razoxane.
A single dose of 200 mg/kg razoxane protected mice against the subchronic lethal effects (i.e. within 21 days) of 10 mg/kg… 
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