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Dexrazoxane hydrochloride

Known as: Hydrochloride, Dexrazoxane, Razoxane, (S)-Isomer, Hydrochloride 
A drug used to treat severe side effects caused by certain anticancer drugs. It is used under the brand name Totect to treat the toxic effects of an… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Although chemotherapy has improved outcome of osteosarcoma, 30–40% of patients succumb to this disease. Survivors experience… Expand
Highly Cited
2014
Highly Cited
2014
BackgroundThe bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced heart failure, but its clinical use is limited… Expand
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2010
2010
OBJECTIVE: To describe a successful case of dexrazoxane treatment after an extravasation of doxorubicin and share a creative… Expand
2005
2005
BACKGROUND AND OBJECTIVE Aim of the present study was to assess the effect of epirubicin-based chemotherapy on QT interval… Expand
2004
2004
The present study investigates the immunological effects of a combination treatment of mitoxantrone and the cardioprotector… Expand
2004
2004
Doxorubicin is a commonly used cytotoxic drug for effective treatment of both solid tumors and leukemias, which may cause severe… Expand
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1997
1997
A Chinese hamster ovary (CHO) cell line highly resistant to the non-cleavable complex-forming topoisomerase II inhibitor… Expand
1997
1997
The antitumor drug mitindomide (NSC 284356) was shown to inhibit the decatenation activity of human and Chinese hamster ovary… Expand
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1996
1996
Etoposide (VP-16)-resistant K562 cells (K/VP.5) were 26-fold resistant to VP-16, due in part to a reduction in DNA topoisomerase… Expand
1996
1996
Anthracyclines are among the most effective and commonly-prescribed antitumor agents but have dose-limiting cumulative… Expand