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Intracerebral metastases in solid‐tumor patients: Natural history and results of treatment
In order to determine the natural history and results of treatment of intracerebral metastases in solid‐tumor patients, the records of 191 patients with an antemortem diagnosis of intracerebral… Expand
Confidence regions for constrained optima in response-surface experiments.
The precision of the estimated optimum from a response-surface experiment is often indicated via a confidence region about the optimum. Sometimes, because of associated secondary responses,… Expand
New ribonucleotide reductase inhibitors with antineoplastic activity.
Abstract For the purpose of developing an effective anticancer agent with a mode of action directed against ribonucleotide reductase, a number of acyl and aryl hydroxamic acids and their congeners… Expand
Hormonal palliation of chemoresistant ovarian cancer: three consecutive phase II trials of the Mid-Atlantic Oncology Program.
- J. Ahlgren, N. Ellison, +7 authors D. Alt
- Journal of clinical oncology : official journal…
- 1 October 1993
PURPOSE To evaluate the efficacy of three hormonal manipulations in the palliation of chemoresistant ovarian cancer, and to analyze the results in the light of other clinical trials. PATIENTS AND… Expand
Cyclophosphamide and CCNU in the treatment of inoperable small cell carcinoma and adenocarcinoma of the lung.
Two hundred and fifty-eight patients with small cell carcinoma and 185 patients with adenocarcinoma were centrally randomized to receive either cyclophosphamide (1000 mg/m2 every 3 weeks) iv or… Expand
Regulation of ribonucleotide reductase in mammalian cells by chemotherapeutic agents.
- H. Elford, B. van't Riet, G. Wampler, A. L. Lin, R. Elford
- Biology, Medicine
- Advances in enzyme regulation
The reductive conversion of ribonucleotides to deoxyribonucleotides is a prime target for the development of a cancer chemotherapeutic agent. A new series of inhibitors based on the polyhydroxy or… Expand
Effect of Tilorone hydrochloride and congeners on reticuloendothelial system, tumors, and the immune response.
Summary Five analogs of Tilorone hydrochloride demonstrated varying degrees of activity on the following host defense mechanisms: ( a ) antitumor activity to Ehrlich carcinoma solid tumor and Friend… Expand
Antileukemic effect of homo-aza-steroidal ester of [p-[bis(2-chloroethyl)amino]phenyl]acetic acid.
The homo-aza-steroidal ester of [p-[bis(2-chloroethyl)amino]phenyl]acetic acid, 3beta-hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17,-lactam p-bis(2-chloroethyl)aminophenylacetate… Expand
A new steroidal alkylating agent with improved activity in advanced murine leukemias
SummaryThe homo-aza-steroidal ester of [p-[bis(2-chloroethyl)amino]phenoxy] acetic acid, 3β-hydroxy 13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)aminophenoxyacetate, gave… Expand
Drug activity and therapeutic synergism in cancer treatment.
In work involving modeling of response surfaces to describe the effects of cancer chemotherapy treatments, it is important to define activity and therapeutic synergism in a statistically defensible… Expand