Dexrazoxane

Known as: 2, 6-Piperazinedione, 4,4'-propylenedi-, (P)- (8CI), Dexrazoxanum, Dexrazoxano 
The active ingredient in a drug used to treat severe side effects caused by certain anticancer drugs. Under the brand name Totect it is used to treat… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
PURPOSE Dexrazoxane is a drug used to prevent anthracycline-induced cardiotoxicity. A recent report found an association between… (More)
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Highly Cited
2007
Highly Cited
2007
Doxorubicin is among the most effective and widely used anticancer drugs in the clinic. However, cardiotoxicity is one of the… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Pediatric Oncology Group (POG) studies 9426 and 9425 evaluated dexrazoxane (DRZ) as a cardiopulmonary protectant during… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Doxorubicin chemotherapy is very effective in children with acute lymphoblastic leukemia (ALL) but also injures… (More)
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Highly Cited
2004
Highly Cited
2004
  • Yaoling Niu
  • 2004
This paper presents the first comprehensive major and trace element data for 130 abyssal peridotite samples from the Pacific and… (More)
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Highly Cited
1999
Highly Cited
1999
-The clinical efficacy of anthracycline antineoplastic agents is limited by a high incidence of severe and usually irreversible… (More)
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Highly Cited
1997
Highly Cited
1997
PURPOSE To determine the cardioprotective effect of dexrazoxane (DZR) used in a doxorubicin-based combination therapy in advanced… (More)
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Review
1997
Review
1997
Advances in the molecular and immunologic characterization of leukemic cells have greatly aided the diagnosis and risk assignment… (More)
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Highly Cited
1997
Highly Cited
1997
PURPOSE To assess whether dexrazoxane (DZR) given after a cumulative doxorubicin dose of 300 mg/m2 confers cardioprotection in… (More)
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Review
1992
Review
1992
The anthracyclines are the class of antitumor drugs with the widest spectrum of activity in human cancers, and only a few cancers… (More)
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