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Dexrazoxane

Known as: 2, 6-Piperazinedione, 4,4'-propylenedi-, (P)- (8CI), Dexrazoxanum, Dexrazoxano 
The active ingredient in a drug used to treat severe side effects caused by certain anticancer drugs. Under the brand name Totect it is used to treat… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Doxorubicin is among the most effective and widely used anticancer drugs in the clinic. However, cardiotoxicity is one of the… Expand
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Highly Cited
2007
Highly Cited
2007
PURPOSE Pediatric Oncology Group (POG) studies 9426 and 9425 evaluated dexrazoxane (DRZ) as a cardiopulmonary protectant during… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The purpose of this study was to assess the efficacy and tolerability of i.v. dexrazoxane [Savene (EU), Totect (US… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Doxorubicin chemotherapy is very effective in children with acute lymphoblastic leukemia (ALL) but also injures… Expand
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Highly Cited
2004
Highly Cited
2004
This paper presents the first comprehensive major and trace element data for � 130 abyssal peridotite samples from the Pacific… Expand
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Highly Cited
2004
Highly Cited
2004
[1] We present new experimentally determined trace element partition coefficients for nine garnet/melt and two clinopyroxene/melt… Expand
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Highly Cited
2002
Highly Cited
2002
Isobaric partial melting experiments were performed on an Fe-free synthetic composition to simulate partial melting of subducted… Expand
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Highly Cited
2000
Highly Cited
2000
Fractionation of some or all of the high field strength elements (HFSE) Nb, Ta, Zr, Hf, and Ti relative to other trace elements… Expand
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Highly Cited
1997
Highly Cited
1997
PURPOSE To determine the cardioprotective effect of dexrazoxane (DZR) used in a doxorubicin-based combination therapy in advanced… Expand
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Review
1992
Review
1992
  • R. Weiss
  • Seminars in oncology
  • 1992
  • Corpus ID: 46289384
The anthracyclines are the class of antitumor drugs with the widest spectrum of activity in human cancers, and only a few cancers… Expand
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