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The risk of cardiotoxicity is the most serious drawback to the clinical usefulness of anthracycline antineoplastic antibiotics… Expand Doxorubicin is among the most effective and widely used anticancer drugs in the clinic. However, cardiotoxicity is one of the… Expand Type IIA topoisomerases both manage the topological state of chromosomal DNA and are the targets of a variety of clinical agents… Expand The nuclear enzyme DNA topoisomerase II is a major target for antineoplastic agents. All topoisomerase II-directed agents are… Expand Anthracycline antibiotics are among the most effective and widely used antineoplastic drugs. Their usefulness is limited by a… Expand PURPOSE
We conducted an open-label, randomized trial to determine whether ICRF-187 would reduce doxorubicin-induced… Expand Certain bis(2,6-dioxopiperazine) derivatives, which include ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl]propane; ADR-529) and… Expand PURPOSE
To test potential protection by ICRF-187 against cumulative doxorubicin-dose-related cardiac toxicity, we conducted a… Expand In this study doxorubicin, epirubicin, and mitoxantrone were compared for their cardiotoxic potential in a chronic mouse model in… Expand Studies in animals suggest that the bispiperazinedione ICRF-187 can prevent the development of dose-related doxorubicin-induced… Expand