Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

ICRF-187

Known as: ICRF 187, ICRF187 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
The risk of cardiotoxicity is the most serious drawback to the clinical usefulness of anthracycline antineoplastic antibiotics… Expand
Highly Cited
2007
Highly Cited
2007
Doxorubicin is among the most effective and widely used anticancer drugs in the clinic. However, cardiotoxicity is one of the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2003
Highly Cited
2003
Type IIA topoisomerases both manage the topological state of chromosomal DNA and are the targets of a variety of clinical agents… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Review
2003
Review
2003
The nuclear enzyme DNA topoisomerase II is a major target for antineoplastic agents. All topoisomerase II-directed agents are… Expand
Review
2000
Review
2000
Anthracycline antibiotics are among the most effective and widely used antineoplastic drugs. Their usefulness is limited by a… Expand
  • figure 1
  • figure 2
Highly Cited
1996
Highly Cited
1996
PURPOSE We conducted an open-label, randomized trial to determine whether ICRF-187 would reduce doxorubicin-induced… Expand
Highly Cited
1994
Highly Cited
1994
Certain bis(2,6-dioxopiperazine) derivatives, which include ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl]propane; ADR-529) and… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 4
  • figure 5
Highly Cited
1992
Highly Cited
1992
PURPOSE To test potential protection by ICRF-187 against cumulative doxorubicin-dose-related cardiac toxicity, we conducted a… Expand
Highly Cited
1992
Highly Cited
1992
In this study doxorubicin, epirubicin, and mitoxantrone were compared for their cardiotoxic potential in a chronic mouse model in… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
1988
Highly Cited
1988
Studies in animals suggest that the bispiperazinedione ICRF-187 can prevent the development of dose-related doxorubicin-induced… Expand