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Serum and glucocorticoid‐inducible kinase (SGK) is a target of the PI 3‐kinase‐stimulated signaling pathway
- Jongsun Park, M. Leong, P. Buse, A. C. Maiyar, G. Firestone, B. Hemmings
- Biology, ChemistryThe EMBO journal
- 1 June 1999
Evidence is presented that SGK is a component of the phosphoinositide 3 (PI 3)‐kinase signaling pathway and that hyperphosphorylation of endogenous SGK, and promoted translocation to the nucleus could be inhibited by wortmannin, but not by rapamycin.
Epithelial sodium channel regulated by aldosterone-induced protein sgk.
- S. Y. Chen, A. Bhargava, D. Pearce
- Biology, MedicineProceedings of the National Academy of Sciences…
- 2 March 1999
Sgk (serum and glucocorticoid-regulated kinase), a member of the serine-threonine kinase family, is identified as an aldosterone-induced regulator of ENaC activity, suggesting that sgk plays a central role in ald testosterone regulation of Na+ absorption and thus in the control of extracellular fluid volume, blood pressure, and sodium homeostasis.
Follicle-Stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinase-independent…
- I. Gonzalez-Robayna, A. E. Falender, S. Ochsner, G. Firestone, J. Richards
- Biology, Computer ScienceMolecular endocrinology
- 1 August 2000
Evidence is provided that FSH, forskolin, and 8-bromo-cAMP stimulate phosphorylation of PKB by mechanisms involving PI3-K (LY294002/wortmannin sensitive) not A kinase (H89 insensitive), a pattern of response mimicking that of IGF-I.
Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum
- M. K. Webster, L. Goya, Y. Ge, A. C. Maiyar, G. Firestone
- BiologyMolecular and cellular biology
- 1 April 1993
This is the first report of a presumed serine/threonine protein kinase that is highly regulated at the transcriptional level by glucocorticoid hormones and suggests a novel interplay between glucoc Corticoid receptor signalling and aprotein kinase of the second messenger family.
SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport.
It is shown that PI3K is required for SGK-dependent stimulation of ENaC-mediated Na+ transport as well as for the production of the phosphorylated form of SGK, which suggests that SGK is a PI3k-dependent integrator of insulin and mineralocorticoid actions that interacts with EN aC subunits to control Na+ entry into kidney collecting duct cells.
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.
- J. Loffing, M. Zečević, F. Verrey
- Biology, MedicineAmerican journal of physiology. Renal physiology
- 1 April 2001
It is shown by real-time RT-PCR and immunofluorescence that an aldosterone injection in adrenalectomized rats induces alpha-ENaC subunit expression along the entire ASDN within 2 h, whereas beta- and gamma- ENaC are constitutively expressed.
Stimulus-Dependent Regulation of Serum and Glucocorticoid Inducible Protein Kinase (SGK) Transcription, Subcellular Localization and Enzymatic Activity
- G. Firestone, Jennifer R Giampaolo, B. O'Keeffe
- BiologyCellular Physiology and Biochemistry
- 28 February 2003
We originally discovered the serum and glucocorticoid inducible protein kinase, SGK, as a novel protein kinase that is under acute transcriptional control by serum and glucocorticoids. An expanding…
Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest.
- S. Paruthiyil, H. Parmar, Vaishali Kerekatte, G. Cunha, G. Firestone, D. Leitman
- Biology, MedicineCancer research
It is demonstrated that ERalpha and ERbeta produce opposite effects in MCF-7 cells on cell proliferation and tumor formation and may be useful for chemoprevention of breast cancer.
Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region
Anticancer activities of artemisinin and its bioactive derivatives
A comprehensive discussion of the pleiotropic response in cancer cells includes growth inhibition by cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration, and modulation of nuclear receptor responsiveness.