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Requirement for Generation of H2O2 for Platelet-Derived Growth Factor Signal Transduction
The results suggest that H2O2 may act as a signal-transducing molecule, and they suggest a potential mechanism for the cardioprotective effects of antioxidants. Expand
Idiopathic nonspecific interstitial pneumonia: prognostic significance of cellular and fibrosing patterns: survival comparison with usual interstitial pneumonia and desquamative interstitial
Based on data, NSIP should be separated into cellular and fibrosing patterns, because these histologic patterns are associated with different clinical characteristics and prognoses. Expand
rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation.
Results suggest that in HeLa cells, rac1 regulates intracellular ROS production and that rac proteins function as part of a redox-dependent signal transduction pathway leading to NF-kappaB activation. Expand
NIH conference. The idiopathic hypereosinophilic syndrome. Clinical, pathophysiologic, and therapeutic considerations.
Chemotherapy to lower the eosinophil counts has resulted in marked improvement of HES prognosis, as have agressive medical and surgical approaches to cardiovascular complications. Expand
Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.
These results provide the first demonstration of the pathway by which ligand stimulation of ROS occurs in non-phagocytic cells and suggest that the family of Ras-related small GTP-binding proteins may function as regulators of the intracellular redox state. Expand
Comprehensive evaluation of 35 patients with lymphangioleiomyomatosis.
Improved diagnostic methods have defined the abnormalities in patients with pulmonary LAM and increased the potential for early recognition and treatment of this disorder. Expand
Nonmuscle myosin II-B is required for normal development of the mouse heart.
It is suggested that nonmuscle myosin II-B is required for normal cardiac myocyte development and that its absence results in structural defects resembling, in part, two common human congenital heart diseases, tetralogy of Fallot and double outlet right ventricle. Expand
ARF-GEP100, a guanine nucleotide-exchange protein for ADP-ribosylation factor 6
A human cDNA encoding an 841-aa guanine nucleotide-exchange protein (GEP) for ADP-ribosylation factors (ARFs), named ARF-GEP100, which contains a Sec7 domain, a pleckstrin homology (PH)-like domain,Expand
Pulmonary Langerhans Cell Granulomatosis (Histiocytosis X) A Clinicopathologic Study of 48 Cases
The frequent finding of intraluminal fibrosis and the frequent peribronchiolar location of PLCG lesions are consistent with the concept that in adults this disorder is associated with an abnormal response to cigarette smoke. Expand
Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B
It is shown that nerve growth factor induces the phosphorylation of Ser 105 of NGFI-B in PC12 phaeochromocytoma cells, resulting in translocation of the NG FI-B–RXR heterodimer complex out of the nucleus using nuclear export signals within NGfi-B. Expand