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Cardiotonic Agents

Known as: Cardioprotective Agent, cardiac stimulant, Myocardial Stimulants 
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other… 
National Institutes of Health

Related topics

Related topics

46 relations

Narrower (38)

6-hydroxymelatoninAcetyldigitoxinsAminophyllineBDF 9148

Broader (2)

Cardiovascular AgentsPharmaceutical Preparations
In BloodMyocardial ContractionNorepinephrineagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Cardiotonic Steroids Stimulate Glycogen Synthesis in Human Skeletal Muscle Cells via a Src- and ERK1/2-dependent Mechanism*
The cardiotonic steroid, ouabain, a specific inhibitor of Na+,K+-ATPase, initiates protein-protein interactions that lead to an… 
Highly Cited
2003
Highly Cited
2003
Ouabain Is a Potent Promoter of Growth and Activator of ERK1/2 in Ouabain-resistant Rat Renal Epithelial Cells*
Endogenous cardiotonic steroids (ECS) are putative ligands of the inhibitory binding site of the membrane sodium pump (Na+, K… 
Highly Cited
2000
Highly Cited
2000
Mammalian Bufadienolide Is Synthesized From Cholesterol in the Adrenal Cortex by a Pathway That Is Independent of Cholesterol Side-Chain Cleavage
An increasing body of evidence suggests that an endogenous mammalian bufadienolide (BD) may be involved in the regulation of Na… 
Review
1995
Review
1995
The effects of various drugs on the myocardial inotropic response.
Highly Cited
1991
Highly Cited
1991
Cardiotonic action of plumbagin on guinea-pig papillary muscle.
Plumbagin, an active principle from Plumbaginaceous plants, produced a triphasic inotropic response (first positive, second… 
Highly Cited
1982
Highly Cited
1982
Cardiovascular Properties of a New Cardiotonic Agent: MDL 17,043 (1,3‐Dihydro-4‐methyl-5-[4-(methylthio)-benzoyl]-2H-imidazol‐2-one)
The cardiovascular properties of a new noncatechol, nonglycoside cardiotonic agent, MDL 17.043, were investigated in anesthetized… 
Highly Cited
1981
Highly Cited
1981
The effects of heart rate on the action potential of guinea‐pig and human ventricular muscle.
1. On increasing the stimulation frequency of isolated pieces of guinea‐pig ventricular muscle, the resting potential depolarizes… 
Highly Cited
1979
Highly Cited
1979
Endogenous digitalis-like activity in the plasma of the toad Bufo marinus
CARDIAC GLYCOSIDES derived from plants have a major role in the pharmacotherapy of cardiac disease, and, because they bind to and… 
Highly Cited
1974
Highly Cited
1974
THE HAEMODYNAMIC EFFECTS OF QUAZODINE, A CARDIAC STIMULANT, IN EXPERIMENTAL E. COLI ENDOTOXIN SHOCK IN THE CAT
SUMMARY 1. Intravenous injections of quazodine (6,7‐dimethoxy‐4‐ethylquinazoline, 0–5 mg/kg per min) in pentobarbitone… 
Highly Cited
1970
Highly Cited
1970
On the reversibility of binding of cardiotonic steroids to a partially purified (Na+K)-activated adenosinetriphosphatase from beef brain.
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