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Role of human cytochrome P4502A6 in C-oxidation of nicotine.
TLDR
The large interindividual variabilities in cotinine formation and immunochemically determined CYP2A6 levels were observed in human liver microsomes, suggesting genetic polymorphism of CYP 2A6. Expand
Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes.
TLDR
Cotinine 3'-hydroxylation appears to be catalyzed solely by CYP2A6 in humans, and is a candidate for a new substrate for CYP3'-hydroxycotinine in humans. Expand
Genetic polymorphisms of CYP2C8 in Japanese population.
TLDR
It appears that the frequencies of these alleles in Japanese are extremely low, concerning the SNPs of T130N, E154D, N193K, K249R, and H411L, and it remains clear that these allels exist as polymorphisms or represent sequence errors or cloning artifacts. Expand
Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells.
TLDR
It is indicated that low concentrations of H2O2 stimulate angiogenesis in BAECs, and the stimulation mechanisms may partially involve the enhancement of proliferation and migration. Expand
Human buprenorphine N-dealkylation is catalyzed by cytochrome P450 3A4.
TLDR
The demonstration of BN N-dealkylation by recombinant CYP3A4 and the agreement in the affinities (apparent KM values) of human liver microsomes and recombinant cytochrome P450 enzyme(s) provide the most supportive evidence for BNN-dealksylation being catalyzed by CYP 3A4. Expand
The effects of selective serotonin reuptake inhibitors and their metabolites on S-mephenytoin 4'-hydroxylase activity in human liver microsomes.
TLDR
It is suggested that some SSRIs and their metabolites with a low Ki value may reduce the clearance of drugs metabolized by this isoform of P450, thereby resulting in a possible drug-drug interaction, when administered simultaneously. Expand
Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans
TLDR
It is found that the CYP2A6 gene was deleted homozygously in one subject who was deficient in cotinine formation from nicotine. Expand
Nicotine metabolism and CYP2A6 allele frequencies in Koreans.
TLDR
It was confirmed that the interindividual difference in nicotine metabolism was closely related to a genetic polymorphism of CYP2A6, which might be due to environmental and/or diet factors as well as genetic factors. Expand
Induction by bufalin of differentiation of human leukemia cells HL60, U937, and ML1 toward macrophage/monocyte-like cells and its potent synergistic effect on the differentiation of human leukemia
TLDR
Results suggest that bufalin in combination with VP16, all-trans retinoic acid, 1 alpha,25-dihydroxyvitamin D3, rTNF-alpha, or gamma-interferon may be very useful in the differentiation of human leukemia. Expand
Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs.
TLDR
The results suggest that bufalin caused a marked decrease in the steady-state level of topo II alpha mRNA, which led to a decreased in the amount and activity of the enzyme and to the induction of apoptosis. Expand
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