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A proton-gated cation channel involved in acid-sensing
TLDR
The biophysical and pharmacological properties of the cloned H+-gated channel (ASIC), for acid-sensing ionic channel that belongs to the amilor-ide-sensitive Na+ channel6–1 Vdegenerin12–14 family of ion channels, closely match those described in sensory neurons. Expand
KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current
TLDR
It is shown that KVLQT1 associates with IsK to form the channel underlying the IKS cardiac current, which is a target of class-Ill anti-arrhythmic drugs and is involved in the L QT1 syndrome. Expand
TASK, a human background K+ channel to sense external pH variations near physiological pH
TLDR
TASK is a new member of the recently recognized TWIK K+ channel family that has four transmembrane segments and two P domains and in adult human, TASK transcripts are found in pancreas. Expand
A Modulatory Subunit of Acid Sensing Ion Channels in Brain and Dorsal Root Ganglion Cells*
TLDR
This work has identified MDEG1 as a proton-gated channel with properties different from those of ASIC, and cloned from mouse and rat brain a splice variant form of the channel which differs in the first 236 amino acids, including the first transmembrane region. Expand
Molecular Cloning of a Non-inactivating Proton-gated Na+ Channel Specific for Sensory Neurons*
TLDR
The cloned and expressed a novel proton-gated Na+ channel subunit that is specific for sensory neurons suggests that it is part of the channel complex responsible for the sustained H+-activated cation current in sensory neurons that is thought to be important for the prolonged perception of pain that accompanies tissue acidosis. Expand
Inhalational anesthetics activate two-pore-domain background K+ channels
TLDR
It is shown that TASK and TREK-1, two recently cloned mammalian two-P-domain K+ channels similar to IKAn in biophysical properties, are activated by volatile general anesthetics. Expand
A mammalian two pore domain mechano‐gated S‐like K+ channel
TLDR
A cloned mammalian two P domain K+ channel sharing the properties of the S channel is identified and it is found that the cytoplasmic C‐terminus contains a charged region critical for chemical and mechanical activation, as well as a phosphorylation site required for cAMP inhibition. Expand
Isolation of a Tarantula Toxin Specific for a Class of Proton-gated Na+ Channels*
TLDR
A novel 40-amino acid toxin from tarantula venom is described, which potently blocks a particular subclass of ASIC channels that are highly expressed in both central nervous system neurons and sensory neurons from dorsal root ganglia. Expand
Nonsteroid Anti-Inflammatory Drugs Inhibit Both the Activity and the Inflammation-Induced Expression of Acid-Sensing Ion Channels in Nociceptors
TLDR
Results suggest that the combined capacity to block COXs and inhibit both inflammation-induced expression and activity of ASICs present in nociceptors is an important factor in the action of NSAIDs against pain. Expand
ASIC3, a sensor of acidic and primary inflammatory pain
TLDR
It is shown that ∼60% of rat cutaneous sensory neurons express ASIC3‐like currents, and peripheral ASIC3 channels are essential sensors of acidic pain and integrators of molecular signals produced during inflammation where they contribute to primary hyperalgesia. Expand
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