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Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
Western blot analyses of highly purified LBs from DLB brains showed that full-length as well as partially truncated and insoluble aggregates of alpha-synuclein are deposited in LBs, which strongly implicate alpha- Synuclein in the formation of LBs and the selective degeneration of neurons in sporadic PD and DLB. Expand
Involvement of Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) in Apoptosis Induced by β-Hydroxyisovalerylshikonin*
Results suggest that suppression of the expression of TRAP1 in mitochondria might play an important role in the induction of apoptosis caused via formation of ROS. Expand
Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells
The results suggest that the activation of AP-1 via a MAPK cascade that includes JNK is required for the induction of apoptosis by bufalin in U937 cells. Expand
Complete amino acid sequence and structure characterization of the taste-modifying protein, miraculin.
The taste-modifying protein, miraculin, has the unusual property of modifying sour taste into sweet taste and high homology was found between the amino acid sequences of miraculin and soybean trypsin inhibitor. Expand
Amino acid sequence and disulfide bridges of an antifungal protein isolated from Aspergillus giganteus.
Results suggest that the antifungal protein forms a loop structure and is similar to phospholipase A2. Expand
Effects of probes of membrane potential on metabolism in synaptosomes.
Effects of three probes for measuring membrane potential, tetraphenylphosphonium (TPP+), rhodamine 6G and 3,3'-dipropylthiocarbocyanine (diS-C3-(5)) on energy metabolism in synaptosomes wereExpand
Fluorescence changes of rhodamine 6G associated with changes in membrane potential in synaptosomes.
The intensity of rhodamine 6G fluorescence was found to be a useful scale for measuring the membrane potential in synaptosomes and the ratio of the permeability constants of a given cation, X+, and K+) was estimated from the calculated membrane potential. Expand
Purification and complete amino acid sequence of a new type of sweet protein taste-modifying activity, curculin.
The results suggest that native curculin is a dimer of a 12,000-Da polypeptide, which elicits a sweet taste and sour substances induce a stronger sense of sweetness. Expand
Induction by bufalin of differentiation of human leukemia cells HL60, U937, and ML1 toward macrophage/monocyte-like cells and its potent synergistic effect on the differentiation of human leukemia
Results suggest that bufalin in combination with VP16, all-trans retinoic acid, 1 alpha,25-dihydroxyvitamin D3, rTNF-alpha, or gamma-interferon may be very useful in the differentiation of human leukemia. Expand
Purification, complete amino acid sequence and structural characterization of the heat-stable sweet protein, mabinlin II.
High similarity was found between the amino acid sequences of mabinlin II and 2S seed storage proteins, especially 2S albumin AT2S3 in Arabidopsis thaliana (mouse-ear cress). Expand