M. Itoigawa

Publications98
h-index31
Citations2,943
Highly Influential Citations90
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Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids.
Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal
TLDR
The existence of two distinct caspase-dependent signal pathways for downregulation of Akt that works as a mechanism of positive feedback regulation for HNE-triggered apoptotic signals are indicated.
Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum.
Chemical constituents of Calophyllum brasiliensis: structure elucidation of seven new xanthones and their cancer chemopreventive activity.
TLDR
Among the xanthones isolated in this study, 4, 5, 6, and 11 were found to exhibit significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.
Distinct involvement of NF‐κB and p38 mitogen‐activated protein kinase pathways in serum deprivation‐mediated stimulation of inducible nitric oxide synthase and its inhibition by 4‐hydroxynonenal
TLDR
Results suggest that NF‐κB and p38 MAP kinase lie in separate signal pathways for serum deprivation‐stimulated iNOS expression and NO production.
Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
TLDR
As a primary screening test for anti-tumor promoters, nine alkaloids isolated from this plant have been tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induction by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).
Induction of apoptosis by carbazole alkaloids isolated from Murraya koenigii.
Chemical constituents of Clausena excavata: isolation and structure elucidation of novel furanone-coumarins with inhibitory effects for tumor-promotion.
TLDR
These furanone-coumarins were found to exhibit inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus early antigen activation in Raji cells, the first example of coumarins with these structural characteristics in nature.
Gamma-lactone carbazoles from Clausena anisata.
The study of chemical constituents of the stems of Clausena anisata collected in Thailand led to the isolation and identification of eight known and two new carbazole alkaloids named…
Chemical constituents of Garcinia fusca: structure elucidation of eight new xanthones and their cancer chemopreventive activity.
TLDR
All the new xanthones were shown to have a terpenoid (prenyl and/or geranyl) side chain(s) in their molecules.
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